Whether to apply row-scaling on the matrix affects the clustering step in consensus partitioning, which might give different partition results on the samples. For the expression matrices, we recommend to scale rows because the more interesting thing is the subgrouping where genes show similar expression patterns in the sense of e.g. genes showing consistent up-regulation in the subgroups. If the rows are not scaled, the partitions are more generally affected by highly expressed genes.

In this analysis, we performed cola analysis on Golub Leukemia dataset by applying row-scaling on the matrix and not. The choice of row-scaling can be tuned by setting scale_rows to TRUE or FALSE in run_all_consensus_partition_methods() or consensus_partition() function.

For the partition methods hclust, kmeans, skmeans, pam and mclust, z-score scaling is applied as \((x-\mu)/\sigma\), and for NMF, the “min-max” scalling is applied as (x - min)/(max - min).

Consensus heatmaps for two subgroups

Figure S10.1A and 1B (switching the tabs in the following figure) illustrate consensus heatmaps for two-group classification with or without row-scaling. Table 1 lists the stability of consensus partition under different methods (measured by 1-PAC scores):

Table 1. 1-PAC scores of the consensus partitioning under each method (k = 2). Partitions with 1-PAC > 0.9 (numbers in red) are considered as stable partitions.
Rows are scaled Rows are unscaled
ATC:skmeans 1 0.67
ATC:kmeans 1 0.66
ATC:NMF 0.97 0.55
SD:skmeans 0.62 1
CV:skmeans 0.63 1
MAD:skmeans 0.64 1
SD:kmeans 0.66 1
CV:kmeans 0.65 1
MAD:kmeans 0.62 1
CV:mclust 0.49 0.98
MAD:mclust 0.82 0.96
SD:mclust 0.37 0.74
CV:NMF 0.63 0.68
MAD:NMF 0.68 0.65
SD:NMF 0.63 0.63
SD:pam 0.55 0.62
MAD:pam 0.65 0.58
CV:pam 0.55 0.55
MAD:hclust 0.23 0.53
ATC:pam 0.6 0.51
SD:hclust 0.24 0.44
ATC:hclust 0.57 0.4
CV:hclust 0.21 0.38
ATC:mclust 0.36 0.36



Rows are scaled

Figure S10.1A. Consensus heatmaps with two subgroups. Matrix rows are scaled.

Figure S10.1A. Consensus heatmaps with two subgroups. Matrix rows are scaled.

Rows are unscaled

Figure S10.1B. Consensus heatmaps with two subgroups. Matrix rows are unscaled.

Figure S10.1B. Consensus heatmaps with two subgroups. Matrix rows are unscaled.

A quick look shows the partitioning results are different when rows are scaled and not. We will discuss with more details in the next section.

Classification from all methods

Figure S10.2 puts classifications from all 24 methods together as well as one clinical annotation. The annotation ALL.AML tells whether the patient (the sample) had ALL or AML. The lightness of the main heatmap corresponds to the silhouette scores for samples measured in each partitioning method. With lighter color, the less stable for the sample to stay in its group.

When the matrix rows are scaled (top heatmap in Figure S10.2), there are two major sets of different classifications where methods integrated with mclust, kmeans, and NMF classify samples into two groups where one group mainly contains AML samples. Other methods integrated with ATC, skmeans and pam generate classifications where a subset of ALL samples move to the same group of AML samples. Although there are two different two-group classifications, the samples that have different classifications among methods generally have lower silhouette scores in the corresponding consensus partition runs ( i.e. the colors in the heatmap are lighter), which means, they are less confident samples for the classifications and different partition methods might classify them into different groups.

When the matrix are not scaled (bottom heatmap in Figure S10.2), the pattern is similar that there are also two sets of classifications. The difference to the top heatmap is now the partitions where features are selected based on row variance (SD/CV/MAD) are more stable in the consensus partitioning procedure while partitions with features selected by ATC are less stable.

Comparing classifications from row-scaling and non-row-scaling, the classifications are similar for both cases. Basically we can make the conclusion that, when rows are scaled, methods with ATC give more stable partitions and when rows are not scaled, methods with SD/CV/MAD give more stable partitions.

Figure S10.2. Classifications from all methods. Column order of the two heatmaps are the same.

Figure S10.2. Classifications from all methods. Column order of the two heatmaps are the same.

To look closer on the different impact on consensus partitioning of applying row-scaling or not, we select the results by ATC:skmeans for the case when matrix rows are scaled and the results by MAD:kmeans for the case when matrix rows are not scaled. The partitionings are stable for the two methods in their settings. Figure S10.3 illustrates how the two classifications correspond.

Figure S10.3. Conseusus partitions from ATC:skmeans and MAD:kmeans methods.

Figure S10.3. Conseusus partitions from ATC:skmeans and MAD:kmeans methods.

We can confirm that MAD:kmeans, row unscaled classification fits very well to the AML/ALL classification, while a subset of ALL samples are classified as the same group as AML samples for the ATC:skmeans, row scaled classification (the green samples on the most right side).

To make it easier to describe, we term the classification from the scaled matrix as \(C_{s, 2}\) (or C_{s,2} if it cannot be rendered as math symbols) and the classification from the unscaled matrix as \(C_{u,2}\) (or C_{u,2}).

We can confirm the separation of the two groups by PCA visualization. PCA is applied to the scaled matrix in Figure S10.4A and to the unscaled matrix in Figure S10.4B. The two plots shows the two classifications can both separate samples very well and seem very reasonable.

Figure S10.4. PCA plots for visualizing the two-group classification. Classification on the left plot is from $C_{s,2}$ and on the right is from $C_{u,2}$.

Figure S10.4. PCA plots for visualizing the two-group classification. Classification on the left plot is from \(C_{s,2}\) and on the right is from \(C_{u,2}\).

Signature genes

Since there are two different classifications, we can next look at the signature genes that are significantly differentially expressed in the two groups, i.e. to compare the signature genes that support the two different classifications.

In Figure S10.5A and S10.5B, the significant genes are simply selected by t-test (FDR < 0.05). According to the heatmaps illustrated in Figure S10.5A and S10.5B, it seems the two different classification are all reasonable that there are many significant genes supporting them, although the number of significant genes in \(C_{s,2}\) are approximate 2 fold more than in \(C_{u,2}\).

Rows are scaled

Figure S10.5A. Signature genes from $C_{s,2}$.

Figure S10.5A. Signature genes from \(C_{s,2}\).

Rows are unscaled

Figure S10.5A. Signature genes from $C_{u,2}$.

Figure S10.5A. Signature genes from \(C_{u,2}\).

The two sets of signature genes have quite large overlap, and they also have their own unique set of genes. \(C_{s,2}\) has 1106 (61%) specific genes and \(C_{u,2}\) has 353 (33%) specific genes (Figure S10.6).

Figure S10.6. Overlap of signature genes in $C_{s,2}$ and $C_{u,2}$.

Figure S10.6. Overlap of signature genes in \(C_{s,2}\) and \(C_{u,2}\).

To see the difference of the three sets of signature genes in Figure S10.6, we make heatmaps for the signature genes specific in classification \(C_{s, 2}\), specific in \(C_{u, 2}\) and those common in the two classifications.

As illustrated in Figure S10.7A and S10.7C, the expression patterns for the signature genes specific in \(C_{s,2}\) or \(C_{u,2}\) are clean that the samples are not separable in the other classification, while in Figure S10.7B where the signature genes are shared by the two classifications, the signature genes show intermeidate expression patterns in the samples that disagree in the two classifcations, they can be classified to different groups by different methods.

Figure S10.7. Heatmaps of $C_{s,2}$ specific signatures, $C_{u,2}$ specific signatures and common signatures in the two classifcations.

Figure S10.7. Heatmaps of \(C_{s,2}\) specific signatures, \(C_{u,2}\) specific signatures and common signatures in the two classifcations.

We term the three categories of signature genes as group A/B/C and we apply Gene Ontology enrichment to the three set of genes by hypergenometric test (with the clusterProfiler package). We only use BP ontologies (Biological Process) and the significant GO terms are filtered by FDR < 0.01. The enriched GO terms are visualized as a heatmap in Figure S10.8 by their similarities between GO terms (with GOSemSim package). GO terms are split and clustered with the simplifyEnrichment package. The keywords of the summaries of GO functions in each cluster are visualized by word clouds.

Again, Figure S10.8 illustrates each set of genes have quite a lot enriched GO terms, which might imply both classification are biologically reasonable.

The complete list of the GO enrichment can be found at the end of this supplementary.

Figure S10.8. Gene ontology enrichment on the three sets of genes illustrated in Figure S10.7.

Figure S10.8. Gene ontology enrichment on the three sets of genes illustrated in Figure S10.7.

Conclusion

As a conclusion for the two-group classification analysis on Golub dataset, we can make following conclusions:

Gene Ontology enrichment

A (686 terms)

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0009725 response to hormone 119/885 987/18670 0.0000 0.0000 119
GO:0051050 positive regulation of transport 115/885 982/18670 0.0000 0.0000 115
GO:0010243 response to organonitrogen compound 110/885 998/18670 0.0000 0.0000 110
GO:1901652 response to peptide 68/885 520/18670 0.0000 0.0000 68
GO:0071417 cellular response to organonitrogen compound 73/885 585/18670 0.0000 0.0000 73
GO:0033993 response to lipid 98/885 923/18670 0.0000 0.0000 98
GO:1901699 cellular response to nitrogen compound 76/885 648/18670 0.0000 0.0000 76
GO:0014070 response to organic cyclic compound 95/885 915/18670 0.0000 0.0000 95
GO:0070482 response to oxygen levels 55/885 394/18670 0.0000 0.0000 55
GO:0019725 cellular homeostasis 98/885 970/18670 0.0000 0.0000 98
GO:0023061 signal release 60/885 462/18670 0.0000 0.0000 60
GO:0051046 regulation of secretion 86/885 811/18670 0.0000 0.0000 86
GO:1903530 regulation of secretion by cell 81/885 753/18670 0.0000 0.0000 81
GO:1901653 cellular response to peptide 52/885 385/18670 0.0000 0.0000 52
GO:0043434 response to peptide hormone 56/885 436/18670 0.0000 0.0000 56
GO:0032870 cellular response to hormone stimulus 76/885 701/18670 0.0000 0.0000 76
GO:0009611 response to wounding 74/885 678/18670 0.0000 0.0000 74
GO:0036293 response to decreased oxygen levels 50/885 370/18670 0.0000 0.0000 50
GO:0001666 response to hypoxia 49/885 359/18670 0.0000 0.0000 49
GO:0046879 hormone secretion 45/885 312/18670 0.0000 0.0000 45
GO:0055082 cellular chemical homeostasis 83/885 812/18670 0.0000 0.0000 83
GO:0030072 peptide hormone secretion 39/885 250/18670 0.0000 0.0000 39
GO:0009914 hormone transport 45/885 322/18670 0.0000 0.0000 45
GO:0090087 regulation of peptide transport 76/885 729/18670 0.0000 0.0000 76
GO:0046887 positive regulation of hormone secretion 27/885 131/18670 0.0000 0.0000 27
GO:0046883 regulation of hormone secretion 40/885 266/18670 0.0000 0.0000 40
GO:0010817 regulation of hormone levels 61/885 529/18670 0.0000 0.0000 61
GO:0002790 peptide secretion 68/885 624/18670 0.0000 0.0000 68
GO:0043066 negative regulation of apoptotic process 88/885 911/18670 0.0000 0.0000 88
GO:0009636 response to toxic substance 60/885 525/18670 0.0000 0.0000 60
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 74/885 719/18670 0.0000 0.0000 74
GO:0061564 axon development 59/885 514/18670 0.0000 0.0000 59
GO:0051098 regulation of binding 48/885 373/18670 0.0000 0.0000 48
GO:1903532 positive regulation of secretion by cell 50/885 399/18670 0.0000 0.0000 50
GO:0043069 negative regulation of programmed cell death 88/885 932/18670 0.0000 0.0000 88
GO:0007409 axonogenesis 55/885 468/18670 0.0000 0.0000 55
GO:0003013 circulatory system process 61/885 551/18670 0.0000 0.0000 61
GO:0042391 regulation of membrane potential 52/885 434/18670 0.0000 0.0000 52
GO:0048732 gland development 52/885 434/18670 0.0000 0.0000 52
GO:0006936 muscle contraction 46/885 360/18670 0.0000 0.0000 46
GO:0090276 regulation of peptide hormone secretion 33/885 208/18670 0.0000 0.0000 33
GO:0048729 tissue morphogenesis 69/885 670/18670 0.0000 0.0000 69
GO:0051047 positive regulation of secretion 51/885 428/18670 0.0000 0.0000 51
GO:0072507 divalent inorganic cation homeostasis 57/885 513/18670 0.0000 0.0000 57
GO:0008015 blood circulation 59/885 541/18670 0.0000 0.0000 59
GO:0071375 cellular response to peptide hormone stimulus 42/885 321/18670 0.0000 0.0000 42
GO:0048545 response to steroid hormone 47/885 385/18670 0.0000 0.0000 47
GO:0008285 negative regulation of cell proliferation 74/885 760/18670 0.0000 0.0000 74
GO:0003012 muscle system process 53/885 465/18670 0.0000 0.0000 53
GO:0070201 regulation of establishment of protein localization 73/885 746/18670 0.0000 0.0000 73
GO:0099536 synaptic signaling 71/885 717/18670 0.0000 0.0000 71
GO:0060322 head development 75/885 776/18670 0.0000 0.0000 75
GO:0072503 cellular divalent inorganic cation homeostasis 55/885 493/18670 0.0000 0.0000 55
GO:0048534 hematopoietic or lymphoid organ development 85/885 929/18670 0.0000 0.0000 85
GO:0006875 cellular metal ion homeostasis 61/885 579/18670 0.0000 0.0000 61
GO:0044419 interspecies interaction between organisms 85/885 932/18670 0.0000 0.0000 85
GO:0030003 cellular cation homeostasis 66/885 652/18670 0.0000 0.0000 66
GO:0002791 regulation of peptide secretion 55/885 500/18670 0.0000 0.0000 55
GO:0060341 regulation of cellular localization 83/885 906/18670 0.0000 0.0000 83
GO:0002520 immune system development 88/885 985/18670 0.0000 0.0000 88
GO:0007268 chemical synaptic transmission 69/885 703/18670 0.0000 0.0000 69
GO:0098916 anterograde trans-synaptic signaling 69/885 703/18670 0.0000 0.0000 69
GO:0032868 response to insulin 37/885 272/18670 0.0000 0.0000 37
GO:0009306 protein secretion 61/885 591/18670 0.0000 0.0000 61
GO:0030097 hemopoiesis 81/885 887/18670 0.0000 0.0000 81
GO:0006873 cellular ion homeostasis 66/885 665/18670 0.0000 0.0000 66
GO:0035239 tube morphogenesis 83/885 920/18670 0.0000 0.0000 83
GO:0008284 positive regulation of cell proliferation 85/885 951/18670 0.0000 0.0000 85
GO:0099537 trans-synaptic signaling 69/885 711/18670 0.0000 0.0000 69
GO:0072358 cardiovascular system development 75/885 801/18670 0.0000 0.0000 75
GO:0009743 response to carbohydrate 33/885 230/18670 0.0000 0.0000 33
GO:0043269 regulation of ion transport 68/885 699/18670 0.0000 0.0000 68
GO:0051223 regulation of protein transport 68/885 699/18670 0.0000 0.0000 68
GO:0001944 vasculature development 74/885 792/18670 0.0000 0.0000 74
GO:0090277 positive regulation of peptide hormone secretion 20/885 96/18670 0.0000 0.0000 20
GO:0032386 regulation of intracellular transport 48/885 423/18670 0.0000 0.0000 48
GO:0120039 plasma membrane bounded cell projection morphogenesis 65/885 662/18670 0.0000 0.0000 65
GO:0048812 neuron projection morphogenesis 64/885 648/18670 0.0000 0.0000 64
GO:0048511 rhythmic process 38/885 295/18670 0.0000 0.0000 38
GO:0018209 peptidyl-serine modification 40/885 322/18670 0.0000 0.0000 40
GO:0048858 cell projection morphogenesis 65/885 666/18670 0.0000 0.0000 65
GO:0055065 metal ion homeostasis 64/885 653/18670 0.0000 0.0000 64
GO:1904951 positive regulation of establishment of protein localization 50/885 456/18670 0.0000 0.0000 50
GO:0048667 cell morphogenesis involved in neuron differentiation 59/885 583/18670 0.0000 0.0000 59
GO:0055074 calcium ion homeostasis 51/885 471/18670 0.0000 0.0000 51
GO:0055080 cation homeostasis 69/885 730/18670 0.0000 0.0000 69
GO:0006935 chemotaxis 63/885 644/18670 0.0000 0.0000 63
GO:0031175 neuron projection development 85/885 978/18670 0.0000 0.0000 85
GO:0007420 brain development 69/885 733/18670 0.0000 0.0000 69
GO:0042330 taxis 63/885 646/18670 0.0000 0.0000 63
GO:0030073 insulin secretion 30/885 207/18670 0.0000 0.0000 30
GO:0050804 modulation of chemical synaptic transmission 48/885 436/18670 0.0000 0.0000 48
GO:0009266 response to temperature stimulus 33/885 243/18670 0.0000 0.0000 33
GO:0099177 regulation of trans-synaptic signaling 48/885 437/18670 0.0000 0.0000 48
GO:0098771 inorganic ion homeostasis 69/885 741/18670 0.0000 0.0000 69
GO:0048863 stem cell differentiation 34/885 257/18670 0.0000 0.0000 34
GO:0071453 cellular response to oxygen levels 32/885 234/18670 0.0000 0.0000 32
GO:0032101 regulation of response to external stimulus 80/885 913/18670 0.0000 0.0000 80
GO:0034762 regulation of transmembrane transport 57/885 568/18670 0.0000 0.0000 57
GO:0032990 cell part morphogenesis 65/885 685/18670 0.0000 0.0000 65
GO:0098657 import into cell 82/885 945/18670 0.0000 0.0000 82
GO:0030001 metal ion transport 78/885 883/18670 0.0000 0.0000 78
GO:0001568 blood vessel development 70/885 761/18670 0.0000 0.0000 70
GO:0044057 regulation of system process 60/885 613/18670 0.0000 0.0000 60
GO:0071407 cellular response to organic cyclic compound 55/885 542/18670 0.0000 0.0000 55
GO:0006874 cellular calcium ion homeostasis 49/885 458/18670 0.0000 0.0000 49
GO:0045471 response to ethanol 22/885 125/18670 0.0000 0.0000 22
GO:0018105 peptidyl-serine phosphorylation 37/885 299/18670 0.0000 0.0000 37
GO:0050878 regulation of body fluid levels 52/885 501/18670 0.0000 0.0000 52
GO:0050801 ion homeostasis 73/885 811/18670 0.0000 0.0000 73
GO:0097190 apoptotic signaling pathway 59/885 602/18670 0.0000 0.0000 59
GO:0071363 cellular response to growth factor stimulus 66/885 706/18670 0.0000 0.0000 66
GO:0043270 positive regulation of ion transport 35/885 275/18670 0.0000 0.0000 35
GO:0002793 positive regulation of peptide secretion 36/885 288/18670 0.0000 0.0000 36
GO:2001233 regulation of apoptotic signaling pathway 45/885 406/18670 0.0000 0.0000 45
GO:0046677 response to antibiotic 39/885 327/18670 0.0000 0.0000 39
GO:0001505 regulation of neurotransmitter levels 41/885 354/18670 0.0000 0.0000 41
GO:0032869 cellular response to insulin stimulus 30/885 216/18670 0.0000 0.0000 30
GO:0048514 blood vessel morphogenesis 64/885 681/18670 0.0000 0.0000 64
GO:0042593 glucose homeostasis 32/885 241/18670 0.0000 0.0000 32
GO:0033500 carbohydrate homeostasis 32/885 242/18670 0.0000 0.0000 32
GO:0071396 cellular response to lipid 59/885 610/18670 0.0000 0.0000 59
GO:0030855 epithelial cell differentiation 70/885 775/18670 0.0000 0.0000 70
GO:0044403 symbiont process 77/885 884/18670 0.0000 0.0000 77
GO:0034284 response to monosaccharide 29/885 207/18670 0.0000 0.0000 29
GO:0009894 regulation of catabolic process 83/885 979/18670 0.0000 0.0000 83
GO:0031347 regulation of defense response 78/885 901/18670 0.0000 0.0000 78
GO:0009749 response to glucose 28/885 197/18670 0.0000 0.0000 28
GO:0070848 response to growth factor 67/885 736/18670 0.0000 0.0000 67
GO:0001525 angiogenesis 57/885 587/18670 0.0000 0.0000 57
GO:0007507 heart development 57/885 587/18670 0.0000 0.0000 57
GO:0015672 monovalent inorganic cation transport 53/885 529/18670 0.0000 0.0000 53
GO:1903522 regulation of blood circulation 36/885 297/18670 0.0000 0.0000 36
GO:0048608 reproductive structure development 46/885 431/18670 0.0000 0.0000 46
GO:0051222 positive regulation of protein transport 45/885 418/18670 0.0000 0.0000 45
GO:0006954 inflammatory response 74/885 848/18670 0.0000 0.0000 74
GO:0061458 reproductive system development 46/885 434/18670 0.0000 0.0000 46
GO:0090066 regulation of anatomical structure size 51/885 506/18670 0.0000 0.0000 51
GO:0001816 cytokine production 70/885 790/18670 0.0000 0.0000 70
GO:0000904 cell morphogenesis involved in differentiation 67/885 744/18670 0.0000 0.0000 67
GO:1902803 regulation of synaptic vesicle transport 17/885 84/18670 0.0000 0.0000 17
GO:0009746 response to hexose 28/885 202/18670 0.0000 0.0000 28
GO:0002009 morphogenesis of an epithelium 53/885 537/18670 0.0000 0.0000 53
GO:0031329 regulation of cellular catabolic process 75/885 871/18670 0.0000 0.0000 75
GO:0043065 positive regulation of apoptotic process 62/885 672/18670 0.0000 0.0000 62
GO:0019932 second-messenger-mediated signaling 46/885 439/18670 0.0000 0.0000 46
GO:0036294 cellular response to decreased oxygen levels 29/885 217/18670 0.0000 0.0000 29
GO:0031667 response to nutrient levels 50/885 499/18670 0.0000 0.0000 50
GO:0006937 regulation of muscle contraction 25/885 171/18670 0.0000 0.0000 25
GO:0000165 MAPK cascade 80/885 958/18670 0.0000 0.0000 80
GO:0033674 positive regulation of kinase activity 55/885 573/18670 0.0000 0.0000 55
GO:0071456 cellular response to hypoxia 28/885 207/18670 0.0000 0.0000 28
GO:0099003 vesicle-mediated transport in synapse 28/885 207/18670 0.0000 0.0000 28
GO:0006836 neurotransmitter transport 33/885 269/18670 0.0000 0.0000 33
GO:0016032 viral process 72/885 833/18670 0.0000 0.0000 72
GO:0006942 regulation of striated muscle contraction 18/885 97/18670 0.0000 0.0000 18
GO:0043068 positive regulation of programmed cell death 62/885 680/18670 0.0000 0.0000 62
GO:0016579 protein deubiquitination 34/885 283/18670 0.0000 0.0000 34
GO:0003018 vascular process in circulatory system 25/885 173/18670 0.0000 0.0000 25
GO:0007159 leukocyte cell-cell adhesion 38/885 337/18670 0.0000 0.0000 38
GO:0006941 striated muscle contraction 25/885 174/18670 0.0000 0.0000 25
GO:0042060 wound healing 54/885 564/18670 0.0000 0.0000 54
GO:0070646 protein modification by small protein removal 35/885 299/18670 0.0000 0.0000 35
GO:0010959 regulation of metal ion transport 42/885 394/18670 0.0000 0.0000 42
GO:0023014 signal transduction by protein phosphorylation 80/885 969/18670 0.0000 0.0000 80
GO:0009408 response to heat 25/885 176/18670 0.0000 0.0000 25
GO:0050796 regulation of insulin secretion 25/885 176/18670 0.0000 0.0000 25
GO:0007411 axon guidance 33/885 276/18670 0.0000 0.0000 33
GO:0097485 neuron projection guidance 33/885 277/18670 0.0000 0.0000 33
GO:0071214 cellular response to abiotic stimulus 37/885 331/18670 0.0000 0.0000 37
GO:0104004 cellular response to environmental stimulus 37/885 331/18670 0.0000 0.0000 37
GO:0051347 positive regulation of transferase activity 59/885 649/18670 0.0000 0.0000 59
GO:0050708 regulation of protein secretion 47/885 472/18670 0.0000 0.0000 47
GO:0009991 response to extracellular stimulus 51/885 531/18670 0.0000 0.0000 51
GO:0043393 regulation of protein binding 28/885 217/18670 0.0000 0.0000 28
GO:0010942 positive regulation of cell death 64/885 730/18670 0.0000 0.0001 64
GO:0007568 aging 36/885 321/18670 0.0000 0.0001 36
GO:0040007 growth 80/885 986/18670 0.0000 0.0001 80
GO:0060048 cardiac muscle contraction 21/885 137/18670 0.0000 0.0001 21
GO:0019221 cytokine-mediated signaling pathway 68/885 798/18670 0.0000 0.0001 68
GO:0045597 positive regulation of cell differentiation 80/885 991/18670 0.0000 0.0001 80
GO:0090257 regulation of muscle system process 31/885 259/18670 0.0000 0.0001 31
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 28/885 221/18670 0.0000 0.0001 28
GO:2000736 regulation of stem cell differentiation 19/885 116/18670 0.0000 0.0001 19
GO:0009755 hormone-mediated signaling pathway 29/885 235/18670 0.0000 0.0001 29
GO:0051588 regulation of neurotransmitter transport 21/885 139/18670 0.0000 0.0001 21
GO:0060078 regulation of postsynaptic membrane potential 21/885 140/18670 0.0000 0.0001 21
GO:0050778 positive regulation of immune response 74/885 902/18670 0.0000 0.0001 74
GO:0001101 response to acid chemical 37/885 343/18670 0.0000 0.0001 37
GO:0006887 exocytosis 74/885 903/18670 0.0000 0.0001 74
GO:0003015 heart process 33/885 290/18670 0.0000 0.0001 33
GO:0008016 regulation of heart contraction 30/885 251/18670 0.0000 0.0001 30
GO:0060627 regulation of vesicle-mediated transport 50/885 532/18670 0.0000 0.0001 50
GO:2000300 regulation of synaptic vesicle exocytosis 15/885 78/18670 0.0000 0.0001 15
GO:1903706 regulation of hemopoiesis 46/885 475/18670 0.0000 0.0001 46
GO:0050852 T cell receptor signaling pathway 26/885 202/18670 0.0000 0.0001 26
GO:0045785 positive regulation of cell adhesion 41/885 403/18670 0.0000 0.0001 41
GO:2000027 regulation of animal organ morphogenesis 30/885 253/18670 0.0000 0.0001 30
GO:0051090 regulation of DNA-binding transcription factor activity 43/885 432/18670 0.0000 0.0001 43
GO:0045786 negative regulation of cell cycle 57/885 641/18670 0.0000 0.0001 57
GO:0001817 regulation of cytokine production 62/885 719/18670 0.0000 0.0001 62
GO:0035296 regulation of tube diameter 21/885 143/18670 0.0000 0.0001 21
GO:0050880 regulation of blood vessel size 21/885 143/18670 0.0000 0.0001 21
GO:0097746 regulation of blood vessel diameter 21/885 143/18670 0.0000 0.0001 21
GO:0048771 tissue remodeling 24/885 179/18670 0.0000 0.0001 24
GO:0051051 negative regulation of transport 49/885 522/18670 0.0000 0.0001 49
GO:0022898 regulation of transmembrane transporter activity 31/885 268/18670 0.0000 0.0001 31
GO:0035150 regulation of tube size 21/885 144/18670 0.0000 0.0001 21
GO:0071322 cellular response to carbohydrate stimulus 21/885 144/18670 0.0000 0.0001 21
GO:0022409 positive regulation of cell-cell adhesion 30/885 255/18670 0.0000 0.0001 30
GO:0034764 positive regulation of transmembrane transport 26/885 204/18670 0.0000 0.0001 26
GO:0001656 metanephros development 16/885 90/18670 0.0000 0.0001 16
GO:2001234 negative regulation of apoptotic signaling pathway 28/885 230/18670 0.0000 0.0001 28
GO:0017144 drug metabolic process 70/885 851/18670 0.0000 0.0001 70
GO:0002253 activation of immune response 62/885 724/18670 0.0000 0.0001 62
GO:1903039 positive regulation of leukocyte cell-cell adhesion 27/885 218/18670 0.0000 0.0001 27
GO:0098660 inorganic ion transmembrane transport 69/885 836/18670 0.0000 0.0001 69
GO:0098693 regulation of synaptic vesicle cycle 18/885 112/18670 0.0000 0.0001 18
GO:0033238 regulation of cellular amine metabolic process 15/885 81/18670 0.0000 0.0001 15
GO:0043549 regulation of kinase activity 71/885 870/18670 0.0000 0.0001 71
GO:0098655 cation transmembrane transport 70/885 855/18670 0.0000 0.0001 70
GO:0070838 divalent metal ion transport 46/885 483/18670 0.0000 0.0001 46
GO:0051101 regulation of DNA binding 19/885 124/18670 0.0000 0.0002 19
GO:0050900 leukocyte migration 47/885 499/18670 0.0000 0.0002 47
GO:0055117 regulation of cardiac muscle contraction 15/885 82/18670 0.0000 0.0002 15
GO:0050670 regulation of lymphocyte proliferation 26/885 208/18670 0.0000 0.0002 26
GO:0045055 regulated exocytosis 66/885 794/18670 0.0000 0.0002 66
GO:0032944 regulation of mononuclear cell proliferation 26/885 209/18670 0.0000 0.0002 26
GO:0070663 regulation of leukocyte proliferation 27/885 222/18670 0.0000 0.0002 27
GO:0045860 positive regulation of protein kinase activity 49/885 532/18670 0.0000 0.0002 49
GO:0009612 response to mechanical stimulus 26/885 210/18670 0.0000 0.0002 26
GO:0071560 cellular response to transforming growth factor beta stimulus 29/885 249/18670 0.0000 0.0002 29
GO:0072511 divalent inorganic cation transport 46/885 489/18670 0.0000 0.0002 46
GO:0009308 amine metabolic process 20/885 138/18670 0.0000 0.0002 20
GO:1903037 regulation of leukocyte cell-cell adhesion 33/885 304/18670 0.0000 0.0002 33
GO:0048589 developmental growth 58/885 674/18670 0.0000 0.0002 58
GO:0031960 response to corticosteroid 22/885 162/18670 0.0000 0.0002 22
GO:0040017 positive regulation of locomotion 53/885 598/18670 0.0000 0.0002 53
GO:0003006 developmental process involved in reproduction 58/885 676/18670 0.0000 0.0002 58
GO:2000147 positive regulation of cell motility 51/885 568/18670 0.0000 0.0002 51
GO:0006816 calcium ion transport 42/885 434/18670 0.0000 0.0002 42
GO:0033002 muscle cell proliferation 28/885 239/18670 0.0000 0.0002 28
GO:0051272 positive regulation of cellular component movement 52/885 585/18670 0.0000 0.0002 52
GO:0001678 cellular glucose homeostasis 21/885 152/18670 0.0000 0.0002 21
GO:2001020 regulation of response to DNA damage stimulus 26/885 214/18670 0.0000 0.0003 26
GO:0060047 heart contraction 31/885 280/18670 0.0000 0.0003 31
GO:0007221 positive regulation of transcription of Notch receptor target 7/885 18/18670 0.0000 0.0003 7
GO:0044106 cellular amine metabolic process 19/885 129/18670 0.0000 0.0003 19
GO:0050870 positive regulation of T cell activation 25/885 202/18670 0.0000 0.0003 25
GO:0051924 regulation of calcium ion transport 29/885 254/18670 0.0000 0.0003 29
GO:0045859 regulation of protein kinase activity 65/885 792/18670 0.0000 0.0003 65
GO:0048013 ephrin receptor signaling pathway 15/885 86/18670 0.0000 0.0003 15
GO:0071559 response to transforming growth factor beta 29/885 255/18670 0.0000 0.0003 29
GO:0034765 regulation of ion transmembrane transport 45/885 483/18670 0.0000 0.0003 45
GO:1903311 regulation of mRNA metabolic process 34/885 324/18670 0.0000 0.0003 34
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 29/885 256/18670 0.0000 0.0003 29
GO:0032409 regulation of transporter activity 31/885 283/18670 0.0000 0.0003 31
GO:0051099 positive regulation of binding 23/885 179/18670 0.0000 0.0003 23
GO:0071496 cellular response to external stimulus 35/885 339/18670 0.0000 0.0003 35
GO:0007548 sex differentiation 30/885 270/18670 0.0000 0.0003 30
GO:0000375 RNA splicing, via transesterification reactions 38/885 382/18670 0.0000 0.0003 38
GO:0050727 regulation of inflammatory response 45/885 485/18670 0.0000 0.0003 45
GO:2001236 regulation of extrinsic apoptotic signaling pathway 21/885 155/18670 0.0000 0.0003 21
GO:0072593 reactive oxygen species metabolic process 31/885 284/18670 0.0000 0.0003 31
GO:0070661 leukocyte proliferation 32/885 298/18670 0.0000 0.0003 32
GO:0034612 response to tumor necrosis factor 33/885 312/18670 0.0000 0.0003 33
GO:1905330 regulation of morphogenesis of an epithelium 23/885 180/18670 0.0000 0.0003 23
GO:0050806 positive regulation of synaptic transmission 22/885 168/18670 0.0000 0.0003 22
GO:0042129 regulation of T cell proliferation 21/885 156/18670 0.0000 0.0003 21
GO:0046651 lymphocyte proliferation 30/885 272/18670 0.0000 0.0003 30
GO:1904062 regulation of cation transmembrane transport 35/885 342/18670 0.0000 0.0004 35
GO:0048660 regulation of smooth muscle cell proliferation 22/885 169/18670 0.0000 0.0004 22
GO:0051100 negative regulation of binding 22/885 169/18670 0.0000 0.0004 22
GO:0048872 homeostasis of number of cells 28/885 246/18670 0.0000 0.0004 28
GO:0097755 positive regulation of blood vessel diameter 12/885 59/18670 0.0000 0.0004 12
GO:0070555 response to interleukin-1 25/885 207/18670 0.0000 0.0004 25
GO:0051480 regulation of cytosolic calcium ion concentration 36/885 357/18670 0.0000 0.0004 36
GO:1901019 regulation of calcium ion transmembrane transporter activity 15/885 89/18670 0.0000 0.0004 15
GO:0030155 regulation of cell adhesion 58/885 691/18670 0.0000 0.0004 58
GO:0032943 mononuclear cell proliferation 30/885 274/18670 0.0000 0.0004 30
GO:0071300 cellular response to retinoic acid 13/885 69/18670 0.0000 0.0004 13
GO:0043433 negative regulation of DNA-binding transcription factor activity 22/885 170/18670 0.0000 0.0004 22
GO:0046683 response to organophosphorus 19/885 134/18670 0.0000 0.0004 19
GO:0051384 response to glucocorticoid 20/885 146/18670 0.0000 0.0004 20
GO:0022407 regulation of cell-cell adhesion 39/885 403/18670 0.0000 0.0004 39
GO:0048659 smooth muscle cell proliferation 22/885 171/18670 0.0000 0.0004 22
GO:0044706 multi-multicellular organism process 26/885 222/18670 0.0000 0.0004 26
GO:0009314 response to radiation 42/885 448/18670 0.0000 0.0004 42
GO:0006352 DNA-templated transcription, initiation 28/885 249/18670 0.0000 0.0004 28
GO:0042098 T cell proliferation 23/885 184/18670 0.0000 0.0004 23
GO:0043401 steroid hormone mediated signaling pathway 23/885 184/18670 0.0000 0.0004 23
GO:0031103 axon regeneration 11/885 51/18670 0.0000 0.0004 11
GO:0071383 cellular response to steroid hormone stimulus 28/885 250/18670 0.0000 0.0005 28
GO:0071356 cellular response to tumor necrosis factor 31/885 291/18670 0.0000 0.0005 31
GO:0071326 cellular response to monosaccharide stimulus 19/885 136/18670 0.0000 0.0005 19
GO:0031669 cellular response to nutrient levels 27/885 237/18670 0.0000 0.0005 27
GO:0015837 amine transport 16/885 102/18670 0.0000 0.0005 16
GO:0031099 regeneration 24/885 198/18670 0.0000 0.0005 24
GO:0016071 mRNA metabolic process 69/885 877/18670 0.0000 0.0005 69
GO:0002026 regulation of the force of heart contraction 8/885 27/18670 0.0000 0.0005 8
GO:0072207 metanephric epithelium development 8/885 27/18670 0.0000 0.0005 8
GO:0098810 neurotransmitter reuptake 8/885 27/18670 0.0000 0.0005 8
GO:0034605 cellular response to heat 19/885 137/18670 0.0000 0.0005 19
GO:0051954 positive regulation of amine transport 9/885 35/18670 0.0000 0.0005 9
GO:1901385 regulation of voltage-gated calcium channel activity 9/885 35/18670 0.0000 0.0005 9
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 37/885 379/18670 0.0000 0.0005 37
GO:0000398 mRNA splicing, via spliceosome 37/885 379/18670 0.0000 0.0005 37
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 53/885 622/18670 0.0000 0.0005 53
GO:0030522 intracellular receptor signaling pathway 30/885 280/18670 0.0000 0.0005 30
GO:0035567 non-canonical Wnt signaling pathway 20/885 150/18670 0.0000 0.0005 20
GO:0030048 actin filament-based movement 19/885 138/18670 0.0000 0.0005 19
GO:0048857 neural nucleus development 12/885 62/18670 0.0000 0.0005 12
GO:0032024 positive regulation of insulin secretion 13/885 72/18670 0.0000 0.0006 13
GO:1902036 regulation of hematopoietic stem cell differentiation 13/885 72/18670 0.0000 0.0006 13
GO:0098662 inorganic cation transmembrane transport 61/885 752/18670 0.0000 0.0006 61
GO:0006367 transcription initiation from RNA polymerase II promoter 23/885 188/18670 0.0000 0.0006 23
GO:0046822 regulation of nucleocytoplasmic transport 16/885 104/18670 0.0000 0.0006 16
GO:0046928 regulation of neurotransmitter secretion 16/885 104/18670 0.0000 0.0006 16
GO:0097479 synaptic vesicle localization 21/885 163/18670 0.0000 0.0006 21
GO:1902600 proton transmembrane transport 21/885 163/18670 0.0000 0.0006 21
GO:0035270 endocrine system development 18/885 127/18670 0.0000 0.0006 18
GO:0043620 regulation of DNA-templated transcription in response to stress 18/885 127/18670 0.0000 0.0006 18
GO:0050714 positive regulation of protein secretion 29/885 268/18670 0.0000 0.0006 29
GO:1903169 regulation of calcium ion transmembrane transport 20/885 151/18670 0.0000 0.0006 20
GO:0070252 actin-mediated cell contraction 17/885 116/18670 0.0000 0.0006 17
GO:0060218 hematopoietic stem cell differentiation 14/885 83/18670 0.0000 0.0006 14
GO:0048489 synaptic vesicle transport 20/885 152/18670 0.0000 0.0006 20
GO:0097480 establishment of synaptic vesicle localization 20/885 152/18670 0.0000 0.0006 20
GO:0033555 multicellular organismal response to stress 13/885 73/18670 0.0000 0.0006 13
GO:0051338 regulation of transferase activity 74/885 972/18670 0.0000 0.0007 74
GO:0007599 hemostasis 34/885 341/18670 0.0000 0.0007 34
GO:0062012 regulation of small molecule metabolic process 42/885 459/18670 0.0000 0.0007 42
GO:0017157 regulation of exocytosis 25/885 217/18670 0.0000 0.0007 25
GO:0045766 positive regulation of angiogenesis 24/885 204/18670 0.0000 0.0007 24
GO:0051952 regulation of amine transport 15/885 95/18670 0.0000 0.0007 15
GO:0040008 regulation of growth 56/885 679/18670 0.0000 0.0007 56
GO:0008361 regulation of cell size 22/885 179/18670 0.0000 0.0007 22
GO:0071347 cellular response to interleukin-1 22/885 179/18670 0.0000 0.0007 22
GO:0006913 nucleocytoplasmic transport 34/885 343/18670 0.0000 0.0007 34
GO:0007565 female pregnancy 23/885 192/18670 0.0000 0.0007 23
GO:1901532 regulation of hematopoietic progenitor cell differentiation 14/885 85/18670 0.0000 0.0007 14
GO:1901796 regulation of signal transduction by p53 class mediator 22/885 180/18670 0.0000 0.0008 22
GO:0030879 mammary gland development 19/885 143/18670 0.0000 0.0008 19
GO:0048738 cardiac muscle tissue development 26/885 233/18670 0.0000 0.0008 26
GO:0097305 response to alcohol 26/885 233/18670 0.0000 0.0008 26
GO:0045776 negative regulation of blood pressure 10/885 46/18670 0.0000 0.0008 10
GO:0042110 T cell activation 42/885 464/18670 0.0000 0.0008 42
GO:0050673 epithelial cell proliferation 40/885 434/18670 0.0000 0.0008 40
GO:0032526 response to retinoic acid 16/885 108/18670 0.0000 0.0008 16
GO:0099565 chemical synaptic transmission, postsynaptic 16/885 108/18670 0.0000 0.0008 16
GO:0006091 generation of precursor metabolites and energy 46/885 526/18670 0.0000 0.0008 46
GO:0099504 synaptic vesicle cycle 23/885 194/18670 0.0000 0.0008 23
GO:0051169 nuclear transport 34/885 346/18670 0.0000 0.0008 34
GO:0051591 response to cAMP 15/885 97/18670 0.0000 0.0008 15
GO:0010332 response to gamma radiation 11/885 56/18670 0.0001 0.0009 11
GO:0030335 positive regulation of cell migration 47/885 544/18670 0.0001 0.0009 47
GO:0051590 positive regulation of neurotransmitter transport 9/885 38/18670 0.0001 0.0009 9
GO:1901342 regulation of vasculature development 39/885 422/18670 0.0001 0.0009 39
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 17/885 121/18670 0.0001 0.0009 17
GO:0071333 cellular response to glucose stimulus 18/885 133/18670 0.0001 0.0009 18
GO:0045664 regulation of neuron differentiation 54/885 656/18670 0.0001 0.0009 54
GO:0050678 regulation of epithelial cell proliferation 36/885 378/18670 0.0001 0.0009 36
GO:0060284 regulation of cell development 72/885 953/18670 0.0001 0.0010 72
GO:0043410 positive regulation of MAPK cascade 47/885 546/18670 0.0001 0.0010 47
GO:0008380 RNA splicing 42/885 469/18670 0.0001 0.0010 42
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 13/885 77/18670 0.0001 0.0010 13
GO:0032355 response to estradiol 18/885 134/18670 0.0001 0.0010 18
GO:0007596 blood coagulation 33/885 336/18670 0.0001 0.0010 33
GO:0002764 immune response-regulating signaling pathway 55/885 675/18670 0.0001 0.0010 55
GO:0007517 muscle organ development 38/885 410/18670 0.0001 0.0010 38
GO:0072215 regulation of metanephros development 7/885 23/18670 0.0001 0.0010 7
GO:0072243 metanephric nephron epithelium development 7/885 23/18670 0.0001 0.0010 7
GO:0051129 negative regulation of cellular component organization 59/885 741/18670 0.0001 0.0011 59
GO:0071331 cellular response to hexose stimulus 18/885 135/18670 0.0001 0.0011 18
GO:0060079 excitatory postsynaptic potential 15/885 100/18670 0.0001 0.0011 15
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 11/885 58/18670 0.0001 0.0012 11
GO:0045765 regulation of angiogenesis 36/885 383/18670 0.0001 0.0012 36
GO:0001503 ossification 37/885 398/18670 0.0001 0.0012 37
GO:0031668 cellular response to extracellular stimulus 28/885 268/18670 0.0001 0.0012 28
GO:0019933 cAMP-mediated signaling 22/885 187/18670 0.0001 0.0012 22
GO:0010720 positive regulation of cell development 47/885 553/18670 0.0001 0.0013 47
GO:0080135 regulation of cellular response to stress 59/885 746/18670 0.0001 0.0013 59
GO:0014074 response to purine-containing compound 19/885 149/18670 0.0001 0.0013 19
GO:0046007 negative regulation of activated T cell proliferation 5/885 11/18670 0.0001 0.0013 5
GO:0030163 protein catabolic process 70/885 931/18670 0.0001 0.0013 70
GO:0031102 neuron projection regeneration 11/885 59/18670 0.0001 0.0013 11
GO:0032388 positive regulation of intracellular transport 24/885 215/18670 0.0001 0.0014 24
GO:0050817 coagulation 33/885 342/18670 0.0001 0.0014 33
GO:0071295 cellular response to vitamin 8/885 32/18670 0.0001 0.0014 8
GO:0015980 energy derivation by oxidation of organic compounds 29/885 285/18670 0.0001 0.0014 29
GO:0050863 regulation of T cell activation 31/885 314/18670 0.0001 0.0014 31
GO:0001819 positive regulation of cytokine production 41/885 464/18670 0.0001 0.0015 41
GO:1904018 positive regulation of vasculature development 25/885 230/18670 0.0001 0.0015 25
GO:0043488 regulation of mRNA stability 21/885 177/18670 0.0001 0.0015 21
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 18/885 139/18670 0.0001 0.0015 18
GO:0018149 peptide cross-linking 11/885 60/18670 0.0001 0.0015 11
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 15/885 104/18670 0.0001 0.0017 15
GO:0043254 regulation of protein complex assembly 41/885 467/18670 0.0001 0.0017 41
GO:0002757 immune response-activating signal transduction 52/885 641/18670 0.0001 0.0017 52
GO:0032412 regulation of ion transmembrane transporter activity 27/885 260/18670 0.0001 0.0017 27
GO:0098609 cell-cell adhesion 64/885 839/18670 0.0001 0.0017 64
GO:0060249 anatomical structure homeostasis 39/885 437/18670 0.0001 0.0017 39
GO:0007589 body fluid secretion 14/885 93/18670 0.0001 0.0017 14
GO:0072202 cell differentiation involved in metanephros development 7/885 25/18670 0.0001 0.0017 7
GO:0010035 response to inorganic substance 47/885 562/18670 0.0001 0.0017 47
GO:0007584 response to nutrient 24/885 219/18670 0.0001 0.0017 24
GO:0007610 behavior 49/885 594/18670 0.0001 0.0017 49
GO:0070997 neuron death 33/885 348/18670 0.0001 0.0018 33
GO:0097094 craniofacial suture morphogenesis 6/885 18/18670 0.0001 0.0018 6
GO:0033209 tumor necrosis factor-mediated signaling pathway 20/885 167/18670 0.0001 0.0019 20
GO:0050805 negative regulation of synaptic transmission 12/885 72/18670 0.0001 0.0019 12
GO:0051168 nuclear export 22/885 194/18670 0.0001 0.0020 22
GO:0050671 positive regulation of lymphocyte proliferation 17/885 130/18670 0.0001 0.0020 17
GO:0045926 negative regulation of growth 26/885 249/18670 0.0001 0.0020 26
GO:0001906 cell killing 20/885 168/18670 0.0001 0.0020 20
GO:0002260 lymphocyte homeostasis 11/885 62/18670 0.0001 0.0020 11
GO:0006521 regulation of cellular amino acid metabolic process 11/885 62/18670 0.0001 0.0020 11
GO:0007623 circadian rhythm 23/885 208/18670 0.0001 0.0020 23
GO:0002444 myeloid leukocyte mediated immunity 46/885 551/18670 0.0001 0.0020 46
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 8/885 34/18670 0.0001 0.0021 8
GO:0008217 regulation of blood pressure 21/885 182/18670 0.0002 0.0021 21
GO:0019884 antigen processing and presentation of exogenous antigen 21/885 182/18670 0.0002 0.0021 21
GO:1903524 positive regulation of blood circulation 12/885 73/18670 0.0002 0.0021 12
GO:0032946 positive regulation of mononuclear cell proliferation 17/885 131/18670 0.0002 0.0021 17
GO:0071377 cellular response to glucagon stimulus 7/885 26/18670 0.0002 0.0022 7
GO:0043487 regulation of RNA stability 21/885 183/18670 0.0002 0.0023 21
GO:0048598 embryonic morphogenesis 48/885 586/18670 0.0002 0.0023 48
GO:0097191 extrinsic apoptotic signaling pathway 24/885 224/18670 0.0002 0.0023 24
GO:1903829 positive regulation of cellular protein localization 31/885 324/18670 0.0002 0.0023 31
GO:0030100 regulation of endocytosis 28/885 281/18670 0.0002 0.0024 28
GO:0006119 oxidative phosphorylation 18/885 145/18670 0.0002 0.0024 18
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 6/885 19/18670 0.0002 0.0024 6
GO:1903827 regulation of cellular protein localization 44/885 524/18670 0.0002 0.0024 44
GO:0043408 regulation of MAPK cascade 59/885 768/18670 0.0002 0.0024 59
GO:0031348 negative regulation of defense response 25/885 239/18670 0.0002 0.0025 25
GO:0035850 epithelial cell differentiation involved in kidney development 9/885 44/18670 0.0002 0.0025 9
GO:0046688 response to copper ion 9/885 44/18670 0.0002 0.0025 9
GO:0001508 action potential 17/885 133/18670 0.0002 0.0025 17
GO:0006397 mRNA processing 45/885 541/18670 0.0002 0.0025 45
GO:0006897 endocytosis 62/885 820/18670 0.0002 0.0025 62
GO:1903708 positive regulation of hemopoiesis 21/885 185/18670 0.0002 0.0025 21
GO:0045666 positive regulation of neuron differentiation 34/885 371/18670 0.0002 0.0026 34
GO:0061005 cell differentiation involved in kidney development 10/885 54/18670 0.0002 0.0026 10
GO:0007179 transforming growth factor beta receptor signaling pathway 22/885 199/18670 0.0002 0.0026 22
GO:0061061 muscle structure development 53/885 672/18670 0.0002 0.0026 53
GO:0006163 purine nucleotide metabolic process 47/885 575/18670 0.0002 0.0027 47
GO:0050767 regulation of neurogenesis 62/885 822/18670 0.0002 0.0027 62
GO:1901214 regulation of neuron death 30/885 313/18670 0.0002 0.0027 30
GO:0002275 myeloid cell activation involved in immune response 45/885 544/18670 0.0002 0.0028 45
GO:1903305 regulation of regulated secretory pathway 19/885 160/18670 0.0002 0.0028 19
GO:0006939 smooth muscle contraction 15/885 110/18670 0.0002 0.0028 15
GO:0098739 import across plasma membrane 15/885 110/18670 0.0002 0.0028 15
GO:0014823 response to activity 11/885 65/18670 0.0002 0.0028 11
GO:1905475 regulation of protein localization to membrane 21/885 187/18670 0.0002 0.0028 21
GO:0060123 regulation of growth hormone secretion 5/885 13/18670 0.0002 0.0028 5
GO:0072182 regulation of nephron tubule epithelial cell differentiation 5/885 13/18670 0.0002 0.0028 5
GO:1900272 negative regulation of long-term synaptic potentiation 5/885 13/18670 0.0002 0.0028 5
GO:0033762 response to glucagon 8/885 36/18670 0.0002 0.0029 8
GO:0060428 lung epithelium development 8/885 36/18670 0.0002 0.0029 8
GO:0019395 fatty acid oxidation 14/885 99/18670 0.0002 0.0030 14
GO:0019935 cyclic-nucleotide-mediated signaling 23/885 215/18670 0.0002 0.0030 23
GO:0010975 regulation of neuron projection development 42/885 499/18670 0.0002 0.0030 42
GO:0002478 antigen processing and presentation of exogenous peptide antigen 20/885 175/18670 0.0002 0.0031 20
GO:0048644 muscle organ morphogenesis 13/885 88/18670 0.0002 0.0031 13
GO:0001736 establishment of planar polarity 16/885 124/18670 0.0003 0.0032 16
GO:0007164 establishment of tissue polarity 16/885 124/18670 0.0003 0.0032 16
GO:0048002 antigen processing and presentation of peptide antigen 21/885 189/18670 0.0003 0.0032 21
GO:0003180 aortic valve morphogenesis 7/885 28/18670 0.0003 0.0032 7
GO:0017158 regulation of calcium ion-dependent exocytosis 15/885 112/18670 0.0003 0.0032 15
GO:0070268 cornification 15/885 112/18670 0.0003 0.0032 15
GO:0048638 regulation of developmental growth 32/885 347/18670 0.0003 0.0033 32
GO:0001504 neurotransmitter uptake 9/885 46/18670 0.0003 0.0033 9
GO:0060537 muscle tissue development 36/885 408/18670 0.0003 0.0033 36
GO:0032615 interleukin-12 production 10/885 56/18670 0.0003 0.0033 10
GO:0098586 cellular response to virus 10/885 56/18670 0.0003 0.0033 10
GO:0043299 leukocyte degranulation 44/885 534/18670 0.0003 0.0033 44
GO:0030162 regulation of proteolysis 62/885 831/18670 0.0003 0.0033 62
GO:0018108 peptidyl-tyrosine phosphorylation 33/885 363/18670 0.0003 0.0034 33
GO:0016042 lipid catabolic process 31/885 333/18670 0.0003 0.0034 31
GO:0032147 activation of protein kinase activity 31/885 333/18670 0.0003 0.0034 31
GO:0046006 regulation of activated T cell proliferation 8/885 37/18670 0.0003 0.0034 8
GO:0035265 organ growth 22/885 204/18670 0.0003 0.0034 22
GO:0002027 regulation of heart rate 14/885 101/18670 0.0003 0.0035 14
GO:0034440 lipid oxidation 14/885 101/18670 0.0003 0.0035 14
GO:0097006 regulation of plasma lipoprotein particle levels 14/885 101/18670 0.0003 0.0035 14
GO:0010038 response to metal ion 33/885 364/18670 0.0003 0.0035 33
GO:0007204 positive regulation of cytosolic calcium ion concentration 30/885 319/18670 0.0003 0.0035 30
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 32/885 349/18670 0.0003 0.0035 32
GO:0046649 lymphocyte activation 56/885 733/18670 0.0003 0.0036 56
GO:0002696 positive regulation of leukocyte activation 34/885 380/18670 0.0003 0.0036 34
GO:0009205 purine ribonucleoside triphosphate metabolic process 31/885 335/18670 0.0003 0.0037 31
GO:0015844 monoamine transport 13/885 90/18670 0.0003 0.0037 13
GO:0030901 midbrain development 13/885 90/18670 0.0003 0.0037 13
GO:0050769 positive regulation of neurogenesis 40/885 474/18670 0.0003 0.0037 40
GO:0031333 negative regulation of protein complex assembly 17/885 139/18670 0.0003 0.0037 17
GO:0070665 positive regulation of leukocyte proliferation 17/885 139/18670 0.0003 0.0037 17
GO:0002768 immune response-regulating cell surface receptor signaling pathway 42/885 506/18670 0.0003 0.0037 42
GO:0018212 peptidyl-tyrosine modification 33/885 366/18670 0.0003 0.0038 33
GO:0002438 acute inflammatory response to antigenic stimulus 6/885 21/18670 0.0003 0.0038 6
GO:0014821 phasic smooth muscle contraction 6/885 21/18670 0.0003 0.0038 6
GO:0006611 protein export from nucleus 20/885 179/18670 0.0003 0.0039 20
GO:0060452 positive regulation of cardiac muscle contraction 5/885 14/18670 0.0003 0.0039 5
GO:0060562 epithelial tube morphogenesis 30/885 322/18670 0.0003 0.0039 30
GO:0016572 histone phosphorylation 8/885 38/18670 0.0003 0.0039 8
GO:0046825 regulation of protein export from nucleus 8/885 38/18670 0.0003 0.0039 8
GO:0072073 kidney epithelium development 17/885 140/18670 0.0003 0.0040 17
GO:0060485 mesenchyme development 27/885 278/18670 0.0003 0.0040 27
GO:0002064 epithelial cell development 22/885 207/18670 0.0003 0.0040 22
GO:0035690 cellular response to drug 33/885 369/18670 0.0004 0.0043 33
GO:0009161 ribonucleoside monophosphate metabolic process 32/885 354/18670 0.0004 0.0043 32
GO:0055008 cardiac muscle tissue morphogenesis 11/885 69/18670 0.0004 0.0043 11
GO:0051960 regulation of nervous system development 67/885 927/18670 0.0004 0.0043 67
GO:0002683 negative regulation of immune system process 39/885 463/18670 0.0004 0.0044 39
GO:0032535 regulation of cellular component size 33/885 370/18670 0.0004 0.0044 33
GO:0009167 purine ribonucleoside monophosphate metabolic process 31/885 340/18670 0.0004 0.0045 31
GO:0061138 morphogenesis of a branching epithelium 20/885 182/18670 0.0004 0.0047 20
GO:0009126 purine nucleoside monophosphate metabolic process 31/885 341/18670 0.0004 0.0047 31
GO:0009199 ribonucleoside triphosphate metabolic process 31/885 341/18670 0.0004 0.0047 31
GO:0009615 response to virus 30/885 326/18670 0.0004 0.0047 30
GO:0030258 lipid modification 24/885 238/18670 0.0004 0.0047 24
GO:0097529 myeloid leukocyte migration 22/885 210/18670 0.0004 0.0048 22
GO:0051966 regulation of synaptic transmission, glutamatergic 11/885 70/18670 0.0004 0.0048 11
GO:0007269 neurotransmitter secretion 19/885 169/18670 0.0004 0.0048 19
GO:0050728 negative regulation of inflammatory response 19/885 169/18670 0.0004 0.0048 19
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 13/885 93/18670 0.0004 0.0048 13
GO:0035249 synaptic transmission, glutamatergic 13/885 93/18670 0.0004 0.0048 13
GO:0055017 cardiac muscle tissue growth 14/885 105/18670 0.0004 0.0048 14
GO:1902750 negative regulation of cell cycle G2/M phase transition 14/885 105/18670 0.0004 0.0048 14
GO:0009144 purine nucleoside triphosphate metabolic process 31/885 342/18670 0.0004 0.0048 31
GO:0030856 regulation of epithelial cell differentiation 18/885 156/18670 0.0004 0.0048 18
GO:0034767 positive regulation of ion transmembrane transport 18/885 156/18670 0.0004 0.0048 18
GO:0010506 regulation of autophagy 30/885 327/18670 0.0004 0.0048 30
GO:0033157 regulation of intracellular protein transport 23/885 225/18670 0.0005 0.0050 23
GO:0099643 signal release from synapse 19/885 170/18670 0.0005 0.0051 19
GO:0072521 purine-containing compound metabolic process 48/885 613/18670 0.0005 0.0051 48
GO:0060415 muscle tissue morphogenesis 12/885 82/18670 0.0005 0.0051 12
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 5/885 15/18670 0.0005 0.0052 5
GO:0072160 nephron tubule epithelial cell differentiation 5/885 15/18670 0.0005 0.0052 5
GO:1904064 positive regulation of cation transmembrane transport 17/885 144/18670 0.0005 0.0052 17
GO:0019882 antigen processing and presentation 23/885 226/18670 0.0005 0.0052 23
GO:0014706 striated muscle tissue development 34/885 390/18670 0.0005 0.0052 34
GO:0009416 response to light stimulus 29/885 314/18670 0.0005 0.0053 29
GO:0009268 response to pH 8/885 40/18670 0.0005 0.0053 8
GO:0045823 positive regulation of heart contraction 8/885 40/18670 0.0005 0.0053 8
GO:0050832 defense response to fungus 8/885 40/18670 0.0005 0.0053 8
GO:0060401 cytosolic calcium ion transport 19/885 171/18670 0.0005 0.0053 19
GO:0043062 extracellular structure organization 36/885 422/18670 0.0005 0.0054 36
GO:0045165 cell fate commitment 26/885 270/18670 0.0005 0.0054 26
GO:0038093 Fc receptor signaling pathway 24/885 241/18670 0.0005 0.0054 24
GO:0016079 synaptic vesicle exocytosis 15/885 119/18670 0.0005 0.0054 15
GO:0060292 long-term synaptic depression 7/885 31/18670 0.0005 0.0054 7
GO:0090075 relaxation of muscle 7/885 31/18670 0.0005 0.0054 7
GO:0007369 gastrulation 20/885 185/18670 0.0005 0.0054 20
GO:0060402 calcium ion transport into cytosol 18/885 158/18670 0.0005 0.0054 18
GO:0061013 regulation of mRNA catabolic process 21/885 199/18670 0.0005 0.0054 21
GO:0030518 intracellular steroid hormone receptor signaling pathway 16/885 132/18670 0.0005 0.0055 16
GO:0001909 leukocyte mediated cytotoxicity 14/885 107/18670 0.0005 0.0055 14
GO:0042102 positive regulation of T cell proliferation 13/885 95/18670 0.0005 0.0056 13
GO:0050851 antigen receptor-mediated signaling pathway 29/885 316/18670 0.0005 0.0057 29
GO:0006635 fatty acid beta-oxidation 11/885 72/18670 0.0005 0.0057 11
GO:0002274 myeloid leukocyte activation 50/885 651/18670 0.0005 0.0058 50
GO:0006974 cellular response to DNA damage stimulus 62/885 854/18670 0.0006 0.0058 62
GO:0002283 neutrophil activation involved in immune response 40/885 488/18670 0.0006 0.0058 40
GO:0010499 proteasomal ubiquitin-independent protein catabolic process 6/885 23/18670 0.0006 0.0058 6
GO:0072170 metanephric tubule development 6/885 23/18670 0.0006 0.0058 6
GO:2000637 positive regulation of gene silencing by miRNA 6/885 23/18670 0.0006 0.0058 6
GO:0031349 positive regulation of defense response 42/885 521/18670 0.0006 0.0060 42
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 14/885 108/18670 0.0006 0.0060 14
GO:0050867 positive regulation of cell activation 34/885 394/18670 0.0006 0.0060 34
GO:0002429 immune response-activating cell surface receptor signaling pathway 39/885 473/18670 0.0006 0.0060 39
GO:0048167 regulation of synaptic plasticity 20/885 187/18670 0.0006 0.0060 20
GO:0050798 activated T cell proliferation 8/885 41/18670 0.0006 0.0060 8
GO:0002262 myeloid cell homeostasis 17/885 147/18670 0.0006 0.0062 17
GO:0010212 response to ionizing radiation 17/885 147/18670 0.0006 0.0062 17
GO:0007006 mitochondrial membrane organization 16/885 134/18670 0.0006 0.0062 16
GO:0045596 negative regulation of cell differentiation 56/885 755/18670 0.0006 0.0062 56
GO:0003007 heart morphogenesis 25/885 259/18670 0.0006 0.0062 25
GO:0003208 cardiac ventricle morphogenesis 11/885 73/18670 0.0006 0.0062 11
GO:0097435 supramolecular fiber organization 51/885 671/18670 0.0006 0.0062 51
GO:0046824 positive regulation of nucleocytoplasmic transport 10/885 62/18670 0.0006 0.0063 10
GO:0051251 positive regulation of lymphocyte activation 30/885 334/18670 0.0006 0.0063 30
GO:0003176 aortic valve development 7/885 32/18670 0.0006 0.0063 7
GO:0042311 vasodilation 7/885 32/18670 0.0006 0.0063 7
GO:0044257 cellular protein catabolic process 57/885 773/18670 0.0006 0.0064 57
GO:0032102 negative regulation of response to external stimulus 32/885 365/18670 0.0006 0.0064 32
GO:2001022 positive regulation of response to DNA damage stimulus 13/885 97/18670 0.0007 0.0065 13
GO:0044242 cellular lipid catabolic process 22/885 217/18670 0.0007 0.0066 22
GO:0030252 growth hormone secretion 5/885 16/18670 0.0007 0.0066 5
GO:0045989 positive regulation of striated muscle contraction 5/885 16/18670 0.0007 0.0066 5
GO:0071871 response to epinephrine 5/885 16/18670 0.0007 0.0066 5
GO:0002366 leukocyte activation involved in immune response 53/885 707/18670 0.0007 0.0066 53
GO:0009620 response to fungus 9/885 52/18670 0.0007 0.0067 9
GO:2000677 regulation of transcription regulatory region DNA binding 9/885 52/18670 0.0007 0.0067 9
GO:0009150 purine ribonucleotide metabolic process 43/885 542/18670 0.0007 0.0068 43
GO:0042445 hormone metabolic process 23/885 232/18670 0.0007 0.0068 23
GO:0031670 cellular response to nutrient 11/885 74/18670 0.0007 0.0068 11
GO:0090175 regulation of establishment of planar polarity 14/885 110/18670 0.0007 0.0068 14
GO:0010001 glial cell differentiation 22/885 218/18670 0.0007 0.0069 22
GO:0009117 nucleotide metabolic process 53/885 709/18670 0.0007 0.0070 53
GO:0035637 multicellular organismal signaling 21/885 204/18670 0.0007 0.0070 21
GO:0051928 positive regulation of calcium ion transport 15/885 123/18670 0.0007 0.0070 15
GO:0060148 positive regulation of posttranscriptional gene silencing 6/885 24/18670 0.0007 0.0070 6
GO:0001776 leukocyte homeostasis 12/885 86/18670 0.0007 0.0070 12
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 12/885 86/18670 0.0007 0.0070 12
GO:0090559 regulation of membrane permeability 12/885 86/18670 0.0007 0.0070 12
GO:0031214 biomineral tissue development 18/885 163/18670 0.0007 0.0072 18
GO:0019693 ribose phosphate metabolic process 45/885 577/18670 0.0007 0.0072 45
GO:0002263 cell activation involved in immune response 53/885 711/18670 0.0008 0.0073 53
GO:0010737 protein kinase A signaling 7/885 33/18670 0.0008 0.0073 7
GO:0033028 myeloid cell apoptotic process 7/885 33/18670 0.0008 0.0073 7
GO:0099084 postsynaptic specialization organization 7/885 33/18670 0.0008 0.0073 7
GO:0030099 myeloid cell differentiation 35/885 416/18670 0.0008 0.0073 35
GO:0008544 epidermis development 38/885 464/18670 0.0008 0.0074 38
GO:0009895 negative regulation of catabolic process 28/885 308/18670 0.0008 0.0074 28
GO:0048588 developmental cell growth 23/885 234/18670 0.0008 0.0074 23
GO:0050679 positive regulation of epithelial cell proliferation 21/885 206/18670 0.0008 0.0077 21
GO:0044087 regulation of cellular component biogenesis 67/885 954/18670 0.0008 0.0077 67
GO:0021762 substantia nigra development 8/885 43/18670 0.0008 0.0077 8
GO:0034383 low-density lipoprotein particle clearance 8/885 43/18670 0.0008 0.0077 8
GO:1904646 cellular response to amyloid-beta 8/885 43/18670 0.0008 0.0077 8
GO:0046777 protein autophosphorylation 23/885 235/18670 0.0008 0.0078 23
GO:0042119 neutrophil activation 40/885 498/18670 0.0008 0.0078 40
GO:0060419 heart growth 14/885 112/18670 0.0008 0.0079 14
GO:0030432 peristalsis 4/885 10/18670 0.0008 0.0079 4
GO:0070091 glucagon secretion 4/885 10/18670 0.0008 0.0079 4
GO:0002446 neutrophil mediated immunity 40/885 499/18670 0.0009 0.0080 40
GO:0045333 cellular respiration 20/885 193/18670 0.0009 0.0081 20
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 13/885 100/18670 0.0009 0.0081 13
GO:2001023 regulation of response to drug 13/885 100/18670 0.0009 0.0081 13
GO:0006753 nucleoside phosphate metabolic process 53/885 716/18670 0.0009 0.0083 53
GO:0016049 cell growth 39/885 484/18670 0.0009 0.0084 39
GO:0032655 regulation of interleukin-12 production 9/885 54/18670 0.0009 0.0084 9
GO:0070206 protein trimerization 9/885 54/18670 0.0009 0.0084 9
GO:1904645 response to amyloid-beta 9/885 54/18670 0.0009 0.0084 9
GO:0045088 regulation of innate immune response 37/885 452/18670 0.0009 0.0084 37
GO:0010976 positive regulation of neuron projection development 26/885 281/18670 0.0009 0.0084 26
GO:0090185 negative regulation of kidney development 5/885 17/18670 0.0009 0.0084 5
GO:0043200 response to amino acid 14/885 113/18670 0.0009 0.0084 14
GO:0048640 negative regulation of developmental growth 14/885 113/18670 0.0009 0.0084 14
GO:0002244 hematopoietic progenitor cell differentiation 18/885 166/18670 0.0009 0.0084 18
GO:1901215 negative regulation of neuron death 21/885 208/18670 0.0009 0.0084 21
GO:0032479 regulation of type I interferon production 15/885 126/18670 0.0009 0.0084 15
GO:0071346 cellular response to interferon-gamma 19/885 180/18670 0.0009 0.0085 19
GO:0043312 neutrophil degranulation 39/885 485/18670 0.0009 0.0085 39
GO:0051249 regulation of lymphocyte activation 39/885 485/18670 0.0009 0.0085 39
GO:0045137 development of primary sexual characteristics 22/885 223/18670 0.0010 0.0086 22
GO:0010463 mesenchymal cell proliferation 8/885 44/18670 0.0010 0.0086 8
GO:0042987 amyloid precursor protein catabolic process 8/885 44/18670 0.0010 0.0086 8
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8/885 44/18670 0.0010 0.0086 8
GO:0090316 positive regulation of intracellular protein transport 17/885 153/18670 0.0010 0.0086 17
GO:0048678 response to axon injury 11/885 77/18670 0.0010 0.0088 11
GO:0051937 catecholamine transport 11/885 77/18670 0.0010 0.0088 11
GO:0051048 negative regulation of secretion 23/885 238/18670 0.0010 0.0088 23
GO:0032602 chemokine production 12/885 89/18670 0.0010 0.0088 12
GO:0002443 leukocyte mediated immunity 62/885 874/18670 0.0010 0.0089 62
GO:0030218 erythrocyte differentiation 14/885 114/18670 0.0010 0.0089 14
GO:0009123 nucleoside monophosphate metabolic process 32/885 375/18670 0.0010 0.0089 32
GO:0046888 negative regulation of hormone secretion 10/885 66/18670 0.0010 0.0092 10
GO:1905710 positive regulation of membrane permeability 10/885 66/18670 0.0010 0.0092 10
GO:0017156 calcium ion regulated exocytosis 17/885 154/18670 0.0010 0.0092 17
GO:0036230 granulocyte activation 40/885 504/18670 0.0010 0.0092 40
GO:0051402 neuron apoptotic process 23/885 239/18670 0.0010 0.0092 23
GO:0043523 regulation of neuron apoptotic process 21/885 210/18670 0.0010 0.0092 21
GO:0010522 regulation of calcium ion transport into cytosol 13/885 102/18670 0.0011 0.0093 13
GO:0001763 morphogenesis of a branching structure 20/885 196/18670 0.0011 0.0093 20
GO:0002685 regulation of leukocyte migration 20/885 196/18670 0.0011 0.0093 20
GO:0050808 synapse organization 34/885 408/18670 0.0011 0.0093 34
GO:0001738 morphogenesis of a polarized epithelium 16/885 141/18670 0.0011 0.0094 16
GO:0008286 insulin receptor signaling pathway 16/885 141/18670 0.0011 0.0094 16
GO:0010948 negative regulation of cell cycle process 31/885 361/18670 0.0011 0.0094 31
GO:0032496 response to lipopolysaccharide 29/885 330/18670 0.0011 0.0094 29
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 11/885 78/18670 0.0011 0.0095 11
GO:0002687 positive regulation of leukocyte migration 15/885 128/18670 0.0011 0.0095 15
GO:0032606 type I interferon production 15/885 128/18670 0.0011 0.0095 15
GO:0006813 potassium ion transport 23/885 240/18670 0.0011 0.0095 23
GO:0032735 positive regulation of interleukin-12 production 7/885 35/18670 0.0011 0.0095 7
GO:0110111 negative regulation of animal organ morphogenesis 7/885 35/18670 0.0011 0.0095 7
GO:1902991 regulation of amyloid precursor protein catabolic process 7/885 35/18670 0.0011 0.0095 7
GO:0070372 regulation of ERK1 and ERK2 cascade 27/885 300/18670 0.0011 0.0096 27
GO:0001974 blood vessel remodeling 8/885 45/18670 0.0011 0.0096 8
GO:0009141 nucleoside triphosphate metabolic process 31/885 362/18670 0.0011 0.0097 31
GO:0034114 regulation of heterotypic cell-cell adhesion 6/885 26/18670 0.0011 0.0098 6
GO:0060037 pharyngeal system development 6/885 26/18670 0.0011 0.0098 6
GO:0032091 negative regulation of protein binding 13/885 103/18670 0.0012 0.0099 13
GO:0048259 regulation of receptor-mediated endocytosis 13/885 103/18670 0.0012 0.0099 13
GO:0010769 regulation of cell morphogenesis involved in differentiation 27/885 301/18670 0.0012 0.0099 27

B (601 terms)

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:1903047 mitotic cell cycle process 83/594 873/18670 0.0000 0.0000 83
GO:0010948 negative regulation of cell cycle process 51/594 361/18670 0.0000 0.0000 51
GO:0002366 leukocyte activation involved in immune response 73/594 707/18670 0.0000 0.0000 73
GO:0002263 cell activation involved in immune response 73/594 711/18670 0.0000 0.0000 73
GO:0002274 myeloid leukocyte activation 67/594 651/18670 0.0000 0.0000 67
GO:0016032 viral process 77/594 833/18670 0.0000 0.0000 77
GO:0002443 leukocyte mediated immunity 79/594 874/18670 0.0000 0.0000 79
GO:0044419 interspecies interaction between organisms 82/594 932/18670 0.0000 0.0000 82
GO:0044403 symbiont process 79/594 884/18670 0.0000 0.0000 79
GO:0036230 granulocyte activation 57/594 504/18670 0.0000 0.0000 57
GO:0044772 mitotic cell cycle phase transition 62/594 588/18670 0.0000 0.0000 62
GO:0002275 myeloid cell activation involved in immune response 59/594 544/18670 0.0000 0.0000 59
GO:0042119 neutrophil activation 56/594 498/18670 0.0000 0.0000 56
GO:0044770 cell cycle phase transition 64/594 631/18670 0.0000 0.0000 64
GO:0043299 leukocyte degranulation 58/594 534/18670 0.0000 0.0000 58
GO:0002444 myeloid leukocyte mediated immunity 59/594 551/18670 0.0000 0.0000 59
GO:0045055 regulated exocytosis 72/594 794/18670 0.0000 0.0000 72
GO:0007346 regulation of mitotic cell cycle 64/594 656/18670 0.0000 0.0000 64
GO:0002283 neutrophil activation involved in immune response 54/594 488/18670 0.0000 0.0000 54
GO:0010564 regulation of cell cycle process 71/594 789/18670 0.0000 0.0000 71
GO:0043312 neutrophil degranulation 53/594 485/18670 0.0000 0.0000 53
GO:0045786 negative regulation of cell cycle 62/594 641/18670 0.0000 0.0000 62
GO:0006887 exocytosis 76/594 903/18670 0.0000 0.0000 76
GO:0002446 neutrophil mediated immunity 53/594 499/18670 0.0000 0.0000 53
GO:1901990 regulation of mitotic cell cycle phase transition 48/594 444/18670 0.0000 0.0000 48
GO:1901991 negative regulation of mitotic cell cycle phase transition 35/594 248/18670 0.0000 0.0000 35
GO:1903311 regulation of mRNA metabolic process 40/594 324/18670 0.0000 0.0000 40
GO:0006974 cellular response to DNA damage stimulus 70/594 854/18670 0.0000 0.0000 70
GO:0006260 DNA replication 36/594 274/18670 0.0000 0.0000 36
GO:1901987 regulation of cell cycle phase transition 49/594 480/18670 0.0000 0.0000 49
GO:0045930 negative regulation of mitotic cell cycle 40/594 338/18670 0.0000 0.0000 40
GO:1901988 negative regulation of cell cycle phase transition 35/594 267/18670 0.0000 0.0000 35
GO:0002520 immune system development 75/594 985/18670 0.0000 0.0000 75
GO:0030097 hemopoiesis 70/594 887/18670 0.0000 0.0000 70
GO:0002244 hematopoietic progenitor cell differentiation 27/594 166/18670 0.0000 0.0000 27
GO:0000122 negative regulation of transcription by RNA polymerase II 67/594 839/18670 0.0000 0.0000 67
GO:0048534 hematopoietic or lymphoid organ development 71/594 929/18670 0.0000 0.0000 71
GO:1902749 regulation of cell cycle G2/M phase transition 30/594 213/18670 0.0000 0.0000 30
GO:0006281 DNA repair 51/594 552/18670 0.0000 0.0000 51
GO:0060218 hematopoietic stem cell differentiation 19/594 83/18670 0.0000 0.0000 19
GO:0033993 response to lipid 70/594 923/18670 0.0000 0.0000 70
GO:0016071 mRNA metabolic process 67/594 877/18670 0.0000 0.0000 67
GO:0019221 cytokine-mediated signaling pathway 63/594 798/18670 0.0000 0.0000 63
GO:0010389 regulation of G2/M transition of mitotic cell cycle 28/594 196/18670 0.0000 0.0000 28
GO:1902036 regulation of hematopoietic stem cell differentiation 17/594 72/18670 0.0000 0.0000 17
GO:0033044 regulation of chromosome organization 37/594 342/18670 0.0000 0.0000 37
GO:0000082 G1/S transition of mitotic cell cycle 33/594 279/18670 0.0000 0.0000 33
GO:0070482 response to oxygen levels 40/594 394/18670 0.0000 0.0000 40
GO:0006403 RNA localization 29/594 230/18670 0.0000 0.0000 29
GO:2001252 positive regulation of chromosome organization 25/594 174/18670 0.0000 0.0000 25
GO:0002521 leukocyte differentiation 46/594 515/18670 0.0000 0.0000 46
GO:0001666 response to hypoxia 37/594 359/18670 0.0000 0.0000 37
GO:0070198 protein localization to chromosome, telomeric region 11/594 28/18670 0.0000 0.0000 11
GO:0019439 aromatic compound catabolic process 56/594 712/18670 0.0000 0.0000 56
GO:0044839 cell cycle G2/M phase transition 31/594 266/18670 0.0000 0.0000 31
GO:0044843 cell cycle G1/S phase transition 33/594 298/18670 0.0000 0.0000 33
GO:2000736 regulation of stem cell differentiation 20/594 116/18670 0.0000 0.0000 20
GO:0036293 response to decreased oxygen levels 37/594 370/18670 0.0000 0.0000 37
GO:0000165 MAPK cascade 67/594 958/18670 0.0000 0.0000 67
GO:1901532 regulation of hematopoietic progenitor cell differentiation 17/594 85/18670 0.0000 0.0000 17
GO:0046700 heterocycle catabolic process 54/594 695/18670 0.0000 0.0000 54
GO:0044270 cellular nitrogen compound catabolic process 54/594 696/18670 0.0000 0.0000 54
GO:0000086 G2/M transition of mitotic cell cycle 29/594 247/18670 0.0000 0.0000 29
GO:0023014 signal transduction by protein phosphorylation 67/594 969/18670 0.0000 0.0000 67
GO:1901361 organic cyclic compound catabolic process 56/594 745/18670 0.0000 0.0000 56
GO:0031329 regulation of cellular catabolic process 62/594 871/18670 0.0000 0.0000 62
GO:0034655 nucleobase-containing compound catabolic process 51/594 648/18670 0.0000 0.0000 51
GO:1903405 protein localization to nuclear body 7/594 10/18670 0.0000 0.0000 7
GO:1904851 positive regulation of establishment of protein localization to telomere 7/594 10/18670 0.0000 0.0000 7
GO:1904867 protein localization to Cajal body 7/594 10/18670 0.0000 0.0000 7
GO:0042110 T cell activation 41/594 464/18670 0.0000 0.0000 41
GO:0051052 regulation of DNA metabolic process 39/594 429/18670 0.0000 0.0000 39
GO:0043487 regulation of RNA stability 24/594 183/18670 0.0000 0.0000 24
GO:0033238 regulation of cellular amine metabolic process 16/594 81/18670 0.0000 0.0000 16
GO:0044106 cellular amine metabolic process 20/594 129/18670 0.0000 0.0000 20
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 17/594 93/18670 0.0000 0.0000 17
GO:0044786 cell cycle DNA replication 15/594 71/18670 0.0000 0.0000 15
GO:0034502 protein localization to chromosome 16/594 82/18670 0.0000 0.0000 16
GO:0070201 regulation of establishment of protein localization 55/594 746/18670 0.0000 0.0000 55
GO:0030162 regulation of proteolysis 59/594 831/18670 0.0000 0.0000 59
GO:0032392 DNA geometric change 19/594 119/18670 0.0000 0.0000 19
GO:0046649 lymphocyte activation 54/594 733/18670 0.0000 0.0000 54
GO:0070203 regulation of establishment of protein localization to telomere 7/594 11/18670 0.0000 0.0000 7
GO:0000723 telomere maintenance 22/594 162/18670 0.0000 0.0000 22
GO:0043488 regulation of mRNA stability 23/594 177/18670 0.0000 0.0000 23
GO:0070555 response to interleukin-1 25/594 207/18670 0.0000 0.0000 25
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 15/594 75/18670 0.0000 0.0000 15
GO:0071824 protein-DNA complex subunit organization 30/594 288/18670 0.0000 0.0000 30
GO:0009308 amine metabolic process 20/594 138/18670 0.0000 0.0000 20
GO:0010638 positive regulation of organelle organization 48/594 623/18670 0.0000 0.0000 48
GO:0019882 antigen processing and presentation 26/594 226/18670 0.0000 0.0000 26
GO:0017144 drug metabolic process 59/594 851/18670 0.0000 0.0000 59
GO:0071897 DNA biosynthetic process 24/594 196/18670 0.0000 0.0000 24
GO:0002237 response to molecule of bacterial origin 33/594 343/18670 0.0000 0.0000 33
GO:0006261 DNA-dependent DNA replication 21/594 153/18670 0.0000 0.0000 21
GO:0045088 regulation of innate immune response 39/594 452/18670 0.0000 0.0000 39
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 35/594 379/18670 0.0000 0.0000 35
GO:0000398 mRNA splicing, via spliceosome 35/594 379/18670 0.0000 0.0000 35
GO:0071103 DNA conformation change 32/594 327/18670 0.0000 0.0000 32
GO:2000573 positive regulation of DNA biosynthetic process 14/594 67/18670 0.0000 0.0000 14
GO:0033365 protein localization to organelle 62/594 922/18670 0.0000 0.0000 62
GO:0070202 regulation of establishment of protein localization to chromosome 7/594 12/18670 0.0000 0.0000 7
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 7/594 12/18670 0.0000 0.0000 7
GO:1990173 protein localization to nucleoplasm 7/594 12/18670 0.0000 0.0000 7
GO:0000375 RNA splicing, via transesterification reactions 35/594 382/18670 0.0000 0.0000 35
GO:0060249 anatomical structure homeostasis 38/594 437/18670 0.0000 0.0000 38
GO:0061013 regulation of mRNA catabolic process 24/594 199/18670 0.0000 0.0000 24
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 15/594 79/18670 0.0000 0.0000 15
GO:0065004 protein-DNA complex assembly 27/594 248/18670 0.0000 0.0000 27
GO:0006352 DNA-templated transcription, initiation 27/594 249/18670 0.0000 0.0000 27
GO:0031145 anaphase-promoting complex-dependent catabolic process 15/594 81/18670 0.0000 0.0000 15
GO:0032204 regulation of telomere maintenance 15/594 81/18670 0.0000 0.0000 15
GO:1902750 negative regulation of cell cycle G2/M phase transition 17/594 105/18670 0.0000 0.0000 17
GO:0006397 mRNA processing 43/594 541/18670 0.0000 0.0000 43
GO:0014070 response to organic cyclic compound 61/594 915/18670 0.0000 0.0000 61
GO:0033260 nuclear DNA replication 13/594 60/18670 0.0000 0.0000 13
GO:0032200 telomere organization 22/594 175/18670 0.0000 0.0000 22
GO:0009314 response to radiation 38/594 448/18670 0.0000 0.0000 38
GO:2000278 regulation of DNA biosynthetic process 17/594 108/18670 0.0000 0.0000 17
GO:0030155 regulation of cell adhesion 50/594 691/18670 0.0000 0.0000 50
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 16/594 96/18670 0.0000 0.0000 16
GO:0071396 cellular response to lipid 46/594 610/18670 0.0000 0.0000 46
GO:0006521 regulation of cellular amino acid metabolic process 13/594 62/18670 0.0000 0.0000 13
GO:1904356 regulation of telomere maintenance via telomere lengthening 13/594 62/18670 0.0000 0.0000 13
GO:0071347 cellular response to interleukin-1 22/594 179/18670 0.0000 0.0000 22
GO:0010243 response to organonitrogen compound 64/594 998/18670 0.0000 0.0000 64
GO:0050684 regulation of mRNA processing 19/594 137/18670 0.0000 0.0000 19
GO:0051169 nuclear transport 32/594 346/18670 0.0000 0.0000 32
GO:0051054 positive regulation of DNA metabolic process 25/594 228/18670 0.0000 0.0000 25
GO:0009894 regulation of catabolic process 63/594 979/18670 0.0000 0.0000 63
GO:1904814 regulation of protein localization to chromosome, telomeric region 7/594 14/18670 0.0000 0.0000 7
GO:0010035 response to inorganic substance 43/594 562/18670 0.0000 0.0000 43
GO:0050778 positive regulation of immune response 59/594 902/18670 0.0000 0.0000 59
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 14/594 77/18670 0.0000 0.0000 14
GO:0008380 RNA splicing 38/594 469/18670 0.0000 0.0000 38
GO:0007568 aging 30/594 321/18670 0.0000 0.0000 30
GO:0006367 transcription initiation from RNA polymerase II promoter 22/594 188/18670 0.0000 0.0000 22
GO:0002220 innate immune response activating cell surface receptor signaling pathway 17/594 116/18670 0.0000 0.0000 17
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 10/594 37/18670 0.0000 0.0000 10
GO:0006325 chromatin organization 54/594 800/18670 0.0000 0.0000 54
GO:0052547 regulation of peptidase activity 37/594 452/18670 0.0000 0.0000 37
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 7/594 15/18670 0.0000 0.0000 7
GO:0006913 nucleocytoplasmic transport 31/594 343/18670 0.0000 0.0000 31
GO:1903706 regulation of hemopoiesis 38/594 475/18670 0.0000 0.0000 38
GO:0048863 stem cell differentiation 26/594 257/18670 0.0000 0.0000 26
GO:0006310 DNA recombination 28/594 292/18670 0.0000 0.0000 28
GO:0062012 regulation of small molecule metabolic process 37/594 459/18670 0.0000 0.0000 37
GO:0050821 protein stabilization 21/594 178/18670 0.0000 0.0000 21
GO:0032496 response to lipopolysaccharide 30/594 330/18670 0.0000 0.0000 30
GO:0010833 telomere maintenance via telomere lengthening 14/594 82/18670 0.0000 0.0000 14
GO:0070200 establishment of protein localization to telomere 7/594 16/18670 0.0000 0.0000 7
GO:0043069 negative regulation of programmed cell death 59/594 932/18670 0.0000 0.0000 59
GO:0002218 activation of innate immune response 29/594 319/18670 0.0000 0.0000 29
GO:0031647 regulation of protein stability 27/594 284/18670 0.0000 0.0000 27
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 17/594 125/18670 0.0000 0.0000 17
GO:0032206 positive regulation of telomere maintenance 11/594 51/18670 0.0000 0.0000 11
GO:0071453 cellular response to oxygen levels 24/594 234/18670 0.0000 0.0000 24
GO:0009725 response to hormone 61/594 987/18670 0.0000 0.0000 61
GO:0006401 RNA catabolic process 33/594 397/18670 0.0000 0.0000 33
GO:0002223 stimulatory C-type lectin receptor signaling pathway 16/594 113/18670 0.0000 0.0000 16
GO:0070498 interleukin-1-mediated signaling pathway 15/594 100/18670 0.0000 0.0000 15
GO:0045089 positive regulation of innate immune response 32/594 381/18670 0.0000 0.0000 32
GO:0002576 platelet degranulation 17/594 128/18670 0.0000 0.0000 17
GO:1904872 regulation of telomerase RNA localization to Cajal body 7/594 18/18670 0.0000 0.0000 7
GO:0071456 cellular response to hypoxia 22/594 207/18670 0.0000 0.0000 22
GO:0002478 antigen processing and presentation of exogenous peptide antigen 20/594 175/18670 0.0000 0.0000 20
GO:0032212 positive regulation of telomere maintenance via telomerase 9/594 34/18670 0.0000 0.0000 9
GO:0071478 cellular response to radiation 21/594 191/18670 0.0000 0.0000 21
GO:1901699 cellular response to nitrogen compound 45/594 648/18670 0.0000 0.0000 45
GO:0032210 regulation of telomere maintenance via telomerase 11/594 54/18670 0.0000 0.0000 11
GO:0006278 RNA-dependent DNA biosynthetic process 13/594 77/18670 0.0000 0.0000 13
GO:1902807 negative regulation of cell cycle G1/S phase transition 17/594 131/18670 0.0000 0.0000 17
GO:0071214 cellular response to abiotic stimulus 29/594 331/18670 0.0000 0.0000 29
GO:0104004 cellular response to environmental stimulus 29/594 331/18670 0.0000 0.0000 29
GO:0070897 transcription preinitiation complex assembly 10/594 44/18670 0.0000 0.0000 10
GO:0051050 positive regulation of transport 60/594 982/18670 0.0000 0.0000 60
GO:0002764 immune response-regulating signaling pathway 46/594 675/18670 0.0000 0.0000 46
GO:0090670 RNA localization to Cajal body 7/594 19/18670 0.0000 0.0000 7
GO:0090671 telomerase RNA localization to Cajal body 7/594 19/18670 0.0000 0.0000 7
GO:0090672 telomerase RNA localization 7/594 19/18670 0.0000 0.0000 7
GO:0090685 RNA localization to nucleus 7/594 19/18670 0.0000 0.0000 7
GO:0090407 organophosphate biosynthetic process 47/594 699/18670 0.0000 0.0000 47
GO:0009611 response to wounding 46/594 678/18670 0.0000 0.0000 46
GO:0045597 positive regulation of cell differentiation 60/594 991/18670 0.0000 0.0000 60
GO:0002253 activation of immune response 48/594 724/18670 0.0000 0.0000 48
GO:0080135 regulation of cellular response to stress 49/594 746/18670 0.0000 0.0000 49
GO:0035567 non-canonical Wnt signaling pathway 18/594 150/18670 0.0000 0.0000 18
GO:0042180 cellular ketone metabolic process 24/594 248/18670 0.0000 0.0000 24
GO:0051338 regulation of transferase activity 59/594 972/18670 0.0000 0.0000 59
GO:0051301 cell division 42/594 598/18670 0.0000 0.0000 42
GO:0019884 antigen processing and presentation of exogenous antigen 20/594 182/18670 0.0000 0.0000 20
GO:0051345 positive regulation of hydrolase activity 50/594 771/18670 0.0000 0.0000 50
GO:0008284 positive regulation of cell proliferation 58/594 951/18670 0.0000 0.0000 58
GO:0060341 regulation of cellular localization 56/594 906/18670 0.0000 0.0000 56
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 15/594 108/18670 0.0000 0.0000 15
GO:0036294 cellular response to decreased oxygen levels 22/594 217/18670 0.0000 0.0000 22
GO:2000045 regulation of G1/S transition of mitotic cell cycle 20/594 184/18670 0.0000 0.0000 20
GO:0007004 telomere maintenance via telomerase 12/594 70/18670 0.0000 0.0001 12
GO:0001736 establishment of planar polarity 16/594 124/18670 0.0000 0.0001 16
GO:0007164 establishment of tissue polarity 16/594 124/18670 0.0000 0.0001 16
GO:0032508 DNA duplex unwinding 15/594 110/18670 0.0000 0.0001 15
GO:0090175 regulation of establishment of planar polarity 15/594 110/18670 0.0000 0.0001 15
GO:0045936 negative regulation of phosphate metabolic process 41/594 586/18670 0.0000 0.0001 41
GO:0042063 gliogenesis 26/594 290/18670 0.0000 0.0001 26
GO:0010563 negative regulation of phosphorus metabolic process 41/594 587/18670 0.0000 0.0001 41
GO:0009636 response to toxic substance 38/594 525/18670 0.0000 0.0001 38
GO:0002573 myeloid leukocyte differentiation 21/594 204/18670 0.0000 0.0001 21
GO:0006091 generation of precursor metabolites and energy 38/594 526/18670 0.0000 0.0001 38
GO:0052548 regulation of endopeptidase activity 33/594 425/18670 0.0000 0.0001 33
GO:0009165 nucleotide biosynthetic process 31/594 386/18670 0.0000 0.0001 31
GO:0002768 immune response-regulating cell surface receptor signaling pathway 37/594 506/18670 0.0000 0.0001 37
GO:0048002 antigen processing and presentation of peptide antigen 20/594 189/18670 0.0000 0.0001 20
GO:0030217 T cell differentiation 23/594 240/18670 0.0000 0.0001 23
GO:0009617 response to bacterium 46/594 699/18670 0.0000 0.0001 46
GO:0043620 regulation of DNA-templated transcription in response to stress 16/594 127/18670 0.0000 0.0001 16
GO:1901293 nucleoside phosphate biosynthetic process 31/594 390/18670 0.0000 0.0001 31
GO:0043408 regulation of MAPK cascade 49/594 768/18670 0.0000 0.0001 49
GO:0050792 regulation of viral process 21/594 208/18670 0.0000 0.0001 21
GO:0030098 lymphocyte differentiation 29/594 353/18670 0.0000 0.0001 29
GO:0002758 innate immune response-activating signal transduction 26/594 298/18670 0.0000 0.0001 26
GO:0006457 protein folding 22/594 227/18670 0.0000 0.0001 22
GO:0043066 negative regulation of apoptotic process 55/594 911/18670 0.0000 0.0001 55
GO:0009117 nucleotide metabolic process 46/594 709/18670 0.0000 0.0001 46
GO:0006353 DNA-templated transcription, termination 12/594 75/18670 0.0000 0.0001 12
GO:1904951 positive regulation of establishment of protein localization 34/594 456/18670 0.0000 0.0001 34
GO:0055086 nucleobase-containing small molecule metabolic process 50/594 801/18670 0.0000 0.0001 50
GO:0010212 response to ionizing radiation 17/594 147/18670 0.0000 0.0001 17
GO:0034599 cellular response to oxidative stress 26/594 302/18670 0.0000 0.0001 26
GO:0051236 establishment of RNA localization 20/594 196/18670 0.0000 0.0001 20
GO:0031349 positive regulation of defense response 37/594 521/18670 0.0000 0.0001 37
GO:0006753 nucleoside phosphate metabolic process 46/594 716/18670 0.0000 0.0001 46
GO:0044283 small molecule biosynthetic process 50/594 807/18670 0.0000 0.0001 50
GO:1903827 regulation of cellular protein localization 37/594 524/18670 0.0000 0.0001 37
GO:0045862 positive regulation of proteolysis 29/594 363/18670 0.0000 0.0001 29
GO:0022407 regulation of cell-cell adhesion 31/594 403/18670 0.0000 0.0001 31
GO:0019725 cellular homeostasis 57/594 970/18670 0.0000 0.0001 57
GO:0031347 regulation of defense response 54/594 901/18670 0.0000 0.0001 54
GO:0043484 regulation of RNA splicing 16/594 135/18670 0.0000 0.0001 16
GO:0038061 NIK/NF-kappaB signaling 19/594 183/18670 0.0000 0.0001 19
GO:0016999 antibiotic metabolic process 17/594 151/18670 0.0000 0.0001 17
GO:0043900 regulation of multi-organism process 31/594 405/18670 0.0000 0.0001 31
GO:2000027 regulation of animal organ morphogenesis 23/594 253/18670 0.0000 0.0001 23
GO:0006520 cellular amino acid metabolic process 29/594 366/18670 0.0000 0.0001 29
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 15/594 121/18670 0.0000 0.0002 15
GO:0071216 cellular response to biotic stimulus 22/594 236/18670 0.0000 0.0002 22
GO:0034614 cellular response to reactive oxygen species 18/594 168/18670 0.0000 0.0002 18
GO:0044087 regulation of cellular component biogenesis 56/594 954/18670 0.0000 0.0002 56
GO:1902806 regulation of cell cycle G1/S phase transition 20/594 202/18670 0.0000 0.0002 20
GO:0010720 positive regulation of cell development 38/594 553/18670 0.0000 0.0002 38
GO:0035690 cellular response to drug 29/594 369/18670 0.0000 0.0002 29
GO:0002757 immune response-activating signal transduction 42/594 641/18670 0.0000 0.0002 42
GO:0006275 regulation of DNA replication 14/594 108/18670 0.0000 0.0002 14
GO:0010942 positive regulation of cell death 46/594 730/18670 0.0000 0.0002 46
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 21/594 222/18670 0.0000 0.0002 21
GO:0002429 immune response-activating cell surface receptor signaling pathway 34/594 473/18670 0.0000 0.0002 34
GO:0006289 nucleotide-excision repair 14/594 109/18670 0.0000 0.0002 14
GO:0008334 histone mRNA metabolic process 7/594 25/18670 0.0000 0.0002 7
GO:0070199 establishment of protein localization to chromosome 7/594 25/18670 0.0000 0.0002 7
GO:0010332 response to gamma radiation 10/594 56/18670 0.0000 0.0002 10
GO:0050769 positive regulation of neurogenesis 34/594 474/18670 0.0000 0.0002 34
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 13/594 95/18670 0.0000 0.0002 13
GO:0038093 Fc receptor signaling pathway 22/594 241/18670 0.0000 0.0002 22
GO:0006518 peptide metabolic process 53/594 894/18670 0.0000 0.0002 53
GO:0006418 tRNA aminoacylation for protein translation 9/594 45/18670 0.0000 0.0002 9
GO:0009123 nucleoside monophosphate metabolic process 29/594 375/18670 0.0000 0.0002 29
GO:0070661 leukocyte proliferation 25/594 298/18670 0.0000 0.0002 25
GO:0001738 morphogenesis of a polarized epithelium 16/594 141/18670 0.0000 0.0002 16
GO:0009411 response to UV 16/594 141/18670 0.0000 0.0002 16
GO:0009124 nucleoside monophosphate biosynthetic process 20/594 208/18670 0.0000 0.0002 20
GO:0043065 positive regulation of apoptotic process 43/594 672/18670 0.0000 0.0002 43
GO:0034504 protein localization to nucleus 23/594 262/18670 0.0000 0.0002 23
GO:0071417 cellular response to organonitrogen compound 39/594 585/18670 0.0000 0.0002 39
GO:0050766 positive regulation of phagocytosis 11/594 70/18670 0.0000 0.0002 11
GO:0001817 regulation of cytokine production 45/594 719/18670 0.0000 0.0002 45
GO:0048024 regulation of mRNA splicing, via spliceosome 13/594 98/18670 0.0000 0.0003 13
GO:0050764 regulation of phagocytosis 13/594 98/18670 0.0000 0.0003 13
GO:0050657 nucleic acid transport 19/594 193/18670 0.0000 0.0003 19
GO:0050658 RNA transport 19/594 193/18670 0.0000 0.0003 19
GO:0016579 protein deubiquitination 24/594 283/18670 0.0000 0.0003 24
GO:0043062 extracellular structure organization 31/594 422/18670 0.0000 0.0003 31
GO:0071219 cellular response to molecule of bacterial origin 20/594 212/18670 0.0000 0.0003 20
GO:0071482 cellular response to light stimulus 15/594 129/18670 0.0000 0.0003 15
GO:1903037 regulation of leukocyte cell-cell adhesion 25/594 304/18670 0.0000 0.0003 25
GO:0043068 positive regulation of programmed cell death 43/594 680/18670 0.0000 0.0003 43
GO:0045785 positive regulation of cell adhesion 30/594 403/18670 0.0000 0.0003 30
GO:0072331 signal transduction by p53 class mediator 23/594 267/18670 0.0000 0.0003 23
GO:0006402 mRNA catabolic process 28/594 364/18670 0.0000 0.0003 28
GO:0006270 DNA replication initiation 8/594 37/18670 0.0000 0.0003 8
GO:0043039 tRNA aminoacylation 9/594 48/18670 0.0000 0.0003 9
GO:0048545 response to steroid hormone 29/594 385/18670 0.0000 0.0003 29
GO:0000302 response to reactive oxygen species 21/594 232/18670 0.0000 0.0003 21
GO:0042326 negative regulation of phosphorylation 33/594 468/18670 0.0000 0.0003 33
GO:1905330 regulation of morphogenesis of an epithelium 18/594 180/18670 0.0000 0.0003 18
GO:0010565 regulation of cellular ketone metabolic process 18/594 181/18670 0.0000 0.0004 18
GO:0043549 regulation of kinase activity 51/594 870/18670 0.0000 0.0004 51
GO:0070997 neuron death 27/594 348/18670 0.0000 0.0004 27
GO:0007420 brain development 45/594 733/18670 0.0000 0.0004 45
GO:0043038 amino acid activation 9/594 49/18670 0.0000 0.0004 9
GO:0051123 RNA polymerase II preinitiation complex assembly 7/594 28/18670 0.0000 0.0004 7
GO:0051095 regulation of helicase activity 5/594 12/18670 0.0000 0.0004 5
GO:0045787 positive regulation of cell cycle 29/594 389/18670 0.0000 0.0004 29
GO:0071241 cellular response to inorganic substance 20/594 217/18670 0.0000 0.0004 20
GO:0046651 lymphocyte proliferation 23/594 272/18670 0.0000 0.0004 23
GO:0071826 ribonucleoprotein complex subunit organization 24/594 291/18670 0.0000 0.0004 24
GO:0006979 response to oxidative stress 32/594 451/18670 0.0000 0.0004 32
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 10/594 62/18670 0.0000 0.0004 10
GO:0016444 somatic cell DNA recombination 10/594 62/18670 0.0000 0.0004 10
GO:0032922 circadian regulation of gene expression 10/594 62/18670 0.0000 0.0004 10
GO:0032943 mononuclear cell proliferation 23/594 274/18670 0.0000 0.0004 23
GO:1901998 toxin transport 8/594 39/18670 0.0000 0.0004 8
GO:0050852 T cell receptor signaling pathway 19/594 202/18670 0.0000 0.0004 19
GO:0009416 response to light stimulus 25/594 314/18670 0.0000 0.0005 25
GO:0051962 positive regulation of nervous system development 36/594 541/18670 0.0000 0.0005 36
GO:0048511 rhythmic process 24/594 295/18670 0.0000 0.0005 24
GO:0071407 cellular response to organic cyclic compound 36/594 542/18670 0.0000 0.0005 36
GO:0022618 ribonucleoprotein complex assembly 23/594 277/18670 0.0000 0.0005 23
GO:0030099 myeloid cell differentiation 30/594 416/18670 0.0000 0.0005 30
GO:0050851 antigen receptor-mediated signaling pathway 25/594 316/18670 0.0000 0.0005 25
GO:0001816 cytokine production 47/594 790/18670 0.0000 0.0005 47
GO:0051223 regulation of protein transport 43/594 699/18670 0.0000 0.0005 43
GO:0032481 positive regulation of type I interferon production 11/594 77/18670 0.0000 0.0005 11
GO:0015931 nucleobase-containing compound transport 21/594 241/18670 0.0000 0.0005 21
GO:0007159 leukocyte cell-cell adhesion 26/594 337/18670 0.0000 0.0005 26
GO:0071222 cellular response to lipopolysaccharide 19/594 205/18670 0.0000 0.0005 19
GO:0043902 positive regulation of multi-organism process 18/594 188/18670 0.0000 0.0005 18
GO:0070646 protein modification by small protein removal 24/594 299/18670 0.0000 0.0006 24
GO:0050865 regulation of cell activation 39/594 614/18670 0.0000 0.0006 39
GO:0048524 positive regulation of viral process 13/594 107/18670 0.0000 0.0006 13
GO:0098781 ncRNA transcription 13/594 107/18670 0.0000 0.0006 13
GO:0070317 negative regulation of G0 to G1 transition 8/594 41/18670 0.0000 0.0006 8
GO:0090087 regulation of peptide transport 44/594 729/18670 0.0000 0.0006 44
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 27/594 361/18670 0.0000 0.0006 27
GO:0007623 circadian rhythm 19/594 208/18670 0.0000 0.0006 19
GO:0060322 head development 46/594 776/18670 0.0000 0.0006 46
GO:0034976 response to endoplasmic reticulum stress 23/594 285/18670 0.0000 0.0007 23
GO:0032479 regulation of type I interferon production 14/594 126/18670 0.0000 0.0008 14
GO:0032069 regulation of nuclease activity 6/594 22/18670 0.0000 0.0008 6
GO:0031056 regulation of histone modification 15/594 143/18670 0.0001 0.0008 15
GO:0030198 extracellular matrix organization 27/594 368/18670 0.0001 0.0008 27
GO:2000377 regulation of reactive oxygen species metabolic process 18/594 195/18670 0.0001 0.0008 18
GO:0051347 positive regulation of transferase activity 40/594 649/18670 0.0001 0.0009 40
GO:0034644 cellular response to UV 11/594 82/18670 0.0001 0.0009 11
GO:0006354 DNA-templated transcription, elongation 13/594 112/18670 0.0001 0.0009 13
GO:0032606 type I interferon production 14/594 128/18670 0.0001 0.0009 14
GO:0044089 positive regulation of cellular component biogenesis 35/594 540/18670 0.0001 0.0009 35
GO:0045859 regulation of protein kinase activity 46/594 792/18670 0.0001 0.0010 46
GO:0010499 proteasomal ubiquitin-independent protein catabolic process 6/594 23/18670 0.0001 0.0010 6
GO:2001251 negative regulation of chromosome organization 15/594 146/18670 0.0001 0.0010 15
GO:0051170 import into nucleus 16/594 163/18670 0.0001 0.0010 16
GO:0032870 cellular response to hormone stimulus 42/594 701/18670 0.0001 0.0010 42
GO:1901214 regulation of neuron death 24/594 313/18670 0.0001 0.0011 24
GO:0006368 transcription elongation from RNA polymerase II promoter 11/594 84/18670 0.0001 0.0011 11
GO:0035966 response to topologically incorrect protein 18/594 199/18670 0.0001 0.0011 18
GO:0050863 regulation of T cell activation 24/594 314/18670 0.0001 0.0011 24
GO:1903039 positive regulation of leukocyte cell-cell adhesion 19/594 218/18670 0.0001 0.0011 19
GO:0033151 V(D)J recombination 5/594 15/18670 0.0001 0.0011 5
GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly 5/594 15/18670 0.0001 0.0011 5
GO:1902969 mitotic DNA replication 5/594 15/18670 0.0001 0.0011 5
GO:0070316 regulation of G0 to G1 transition 8/594 45/18670 0.0001 0.0011 8
GO:0072594 establishment of protein localization to organelle 35/594 549/18670 0.0001 0.0012 35
GO:0007569 cell aging 13/594 116/18670 0.0001 0.0012 13
GO:0043687 post-translational protein modification 26/594 361/18670 0.0001 0.0015 26
GO:0006283 transcription-coupled nucleotide-excision repair 10/594 73/18670 0.0001 0.0015 10
GO:0038095 Fc-epsilon receptor signaling pathway 16/594 169/18670 0.0001 0.0015 16
GO:0045023 G0 to G1 transition 8/594 47/18670 0.0001 0.0015 8
GO:0061614 pri-miRNA transcription by RNA polymerase II 8/594 47/18670 0.0001 0.0015 8
GO:0009266 response to temperature stimulus 20/594 243/18670 0.0001 0.0015 20
GO:0001101 response to acid chemical 25/594 343/18670 0.0001 0.0016 25
GO:0045807 positive regulation of endocytosis 15/594 153/18670 0.0001 0.0016 15
GO:0002009 morphogenesis of an epithelium 34/594 537/18670 0.0001 0.0017 34
GO:0002200 somatic diversification of immune receptors 10/594 75/18670 0.0001 0.0018 10
GO:0008584 male gonad development 14/594 138/18670 0.0001 0.0019 14
GO:0097237 cellular response to toxic substance 20/594 247/18670 0.0001 0.0019 20
GO:0019216 regulation of lipid metabolic process 28/594 410/18670 0.0001 0.0019 28
GO:0040007 growth 53/594 986/18670 0.0001 0.0019 53
GO:0008015 blood circulation 34/594 541/18670 0.0001 0.0019 34
GO:0046677 response to antibiotic 24/594 327/18670 0.0001 0.0019 24
GO:1903409 reactive oxygen species biosynthetic process 13/594 122/18670 0.0001 0.0020 13
GO:0042060 wound healing 35/594 564/18670 0.0001 0.0020 35
GO:0097529 myeloid leukocyte migration 18/594 210/18670 0.0001 0.0020 18
GO:0044774 mitotic DNA integrity checkpoint 12/594 106/18670 0.0001 0.0020 12
GO:0006302 double-strand break repair 20/594 248/18670 0.0001 0.0020 20
GO:1901652 response to peptide 33/594 520/18670 0.0001 0.0020 33
GO:0006220 pyrimidine nucleotide metabolic process 9/594 62/18670 0.0001 0.0020 9
GO:0016571 histone methylation 14/594 139/18670 0.0001 0.0020 14
GO:0046546 development of primary male sexual characteristics 14/594 139/18670 0.0001 0.0020 14
GO:0019058 viral life cycle 24/594 328/18670 0.0001 0.0020 24
GO:2000142 regulation of DNA-templated transcription, initiation 7/594 37/18670 0.0001 0.0020 7
GO:0031570 DNA integrity checkpoint 15/594 157/18670 0.0002 0.0021 15
GO:0050878 regulation of body fluid levels 32/594 501/18670 0.0002 0.0022 32
GO:0051168 nuclear export 17/594 194/18670 0.0002 0.0022 17
GO:0006986 response to unfolded protein 16/594 176/18670 0.0002 0.0022 16
GO:0032873 negative regulation of stress-activated MAPK cascade 8/594 50/18670 0.0002 0.0023 8
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 8/594 50/18670 0.0002 0.0023 8
GO:0002449 lymphocyte mediated immunity 25/594 352/18670 0.0002 0.0023 25
GO:0071356 cellular response to tumor necrosis factor 22/594 291/18670 0.0002 0.0023 22
GO:0098727 maintenance of cell number 15/594 159/18670 0.0002 0.0023 15
GO:0034612 response to tumor necrosis factor 23/594 312/18670 0.0002 0.0024 23
GO:0009161 ribonucleoside monophosphate metabolic process 25/594 354/18670 0.0002 0.0024 25
GO:0046782 regulation of viral transcription 9/594 64/18670 0.0002 0.0024 9
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process 4/594 10/18670 0.0002 0.0024 4
GO:0110096 cellular response to aldehyde 4/594 10/18670 0.0002 0.0024 4
GO:0055114 oxidation-reduction process 53/594 999/18670 0.0002 0.0025 53
GO:0048146 positive regulation of fibroblast proliferation 8/594 51/18670 0.0002 0.0025 8
GO:0097366 response to bronchodilator 8/594 51/18670 0.0002 0.0025 8
GO:0003013 circulatory system process 34/594 551/18670 0.0002 0.0025 34
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28/594 419/18670 0.0002 0.0025 28
GO:0010952 positive regulation of peptidase activity 17/594 197/18670 0.0002 0.0026 17
GO:1903312 negative regulation of mRNA metabolic process 10/594 79/18670 0.0002 0.0026 10
GO:0000075 cell cycle checkpoint 18/594 216/18670 0.0002 0.0026 18
GO:0006479 protein methylation 16/594 179/18670 0.0002 0.0026 16
GO:0008213 protein alkylation 16/594 179/18670 0.0002 0.0026 16
GO:0060284 regulation of cell development 51/594 953/18670 0.0002 0.0026 51
GO:0006935 chemotaxis 38/594 644/18670 0.0002 0.0026 38
GO:0022409 positive regulation of cell-cell adhesion 20/594 255/18670 0.0002 0.0026 20
GO:0050686 negative regulation of mRNA processing 6/594 28/18670 0.0002 0.0027 6
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 6/594 28/18670 0.0002 0.0027 6
GO:0071346 cellular response to interferon-gamma 16/594 180/18670 0.0002 0.0027 16
GO:0031960 response to corticosteroid 15/594 162/18670 0.0002 0.0027 15
GO:0042330 taxis 38/594 646/18670 0.0002 0.0028 38
GO:0016447 somatic recombination of immunoglobulin gene segments 8/594 52/18670 0.0002 0.0028 8
GO:0034341 response to interferon-gamma 17/594 199/18670 0.0002 0.0028 17
GO:0048729 tissue morphogenesis 39/594 670/18670 0.0002 0.0028 39
GO:0032386 regulation of intracellular transport 28/594 423/18670 0.0002 0.0029 28
GO:0002285 lymphocyte activation involved in immune response 16/594 181/18670 0.0002 0.0029 16
GO:0043254 regulation of protein complex assembly 30/594 467/18670 0.0002 0.0029 30
GO:0042176 regulation of protein catabolic process 26/594 381/18670 0.0002 0.0029 26
GO:0097327 response to antineoplastic agent 11/594 96/18670 0.0002 0.0029 11
GO:1990823 response to leukemia inhibitory factor 11/594 96/18670 0.0002 0.0029 11
GO:1990830 cellular response to leukemia inhibitory factor 11/594 96/18670 0.0002 0.0029 11
GO:0051384 response to glucocorticoid 14/594 146/18670 0.0002 0.0030 14
GO:0006338 chromatin remodeling 16/594 182/18670 0.0002 0.0030 16
GO:0008217 regulation of blood pressure 16/594 182/18670 0.0002 0.0030 16
GO:0007599 hemostasis 24/594 341/18670 0.0003 0.0032 24
GO:0090263 positive regulation of canonical Wnt signaling pathway 14/594 147/18670 0.0003 0.0032 14
GO:0048709 oligodendrocyte differentiation 11/594 97/18670 0.0003 0.0032 11
GO:0046390 ribose phosphate biosynthetic process 22/594 300/18670 0.0003 0.0032 22
GO:0007093 mitotic cell cycle checkpoint 15/594 165/18670 0.0003 0.0032 15
GO:0050870 positive regulation of T cell activation 17/594 202/18670 0.0003 0.0032 17
GO:0045861 negative regulation of proteolysis 25/594 363/18670 0.0003 0.0033 25
GO:0042098 T cell proliferation 16/594 184/18670 0.0003 0.0033 16
GO:1901653 cellular response to peptide 26/594 385/18670 0.0003 0.0033 26
GO:0034968 histone lysine methylation 12/594 114/18670 0.0003 0.0033 12
GO:0010038 response to metal ion 25/594 364/18670 0.0003 0.0033 25
GO:0050434 positive regulation of viral transcription 7/594 41/18670 0.0003 0.0033 7
GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 7/594 41/18670 0.0003 0.0033 7
GO:0000727 double-strand break repair via break-induced replication 4/594 11/18670 0.0003 0.0033 4
GO:0019042 viral latency 4/594 11/18670 0.0003 0.0033 4
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly 4/594 11/18670 0.0003 0.0033 4
GO:0046185 aldehyde catabolic process 4/594 11/18670 0.0003 0.0033 4
GO:0090329 regulation of DNA-dependent DNA replication 8/594 54/18670 0.0003 0.0034 8
GO:1902275 regulation of chromatin organization 16/594 185/18670 0.0003 0.0035 16
GO:0050767 regulation of neurogenesis 45/594 822/18670 0.0003 0.0035 45
GO:0033209 tumor necrosis factor-mediated signaling pathway 15/594 167/18670 0.0003 0.0035 15
GO:0006970 response to osmotic stress 10/594 83/18670 0.0003 0.0035 10
GO:1903829 positive regulation of cellular protein localization 23/594 324/18670 0.0003 0.0036 23
GO:0006954 inflammatory response 46/594 848/18670 0.0003 0.0036 46
GO:0030595 leukocyte chemotaxis 18/594 224/18670 0.0003 0.0036 18
GO:0072593 reactive oxygen species metabolic process 21/594 284/18670 0.0003 0.0037 21
GO:0031330 negative regulation of cellular catabolic process 20/594 264/18670 0.0003 0.0037 20
GO:0050900 leukocyte migration 31/594 499/18670 0.0003 0.0038 31
GO:0006304 DNA modification 12/594 116/18670 0.0003 0.0038 12
GO:1900180 regulation of protein localization to nucleus 12/594 116/18670 0.0003 0.0038 12
GO:0009615 response to virus 23/594 326/18670 0.0003 0.0038 23
GO:0002320 lymphoid progenitor cell differentiation 5/594 20/18670 0.0003 0.0038 5
GO:0006271 DNA strand elongation involved in DNA replication 5/594 20/18670 0.0003 0.0038 5
GO:0016137 glycoside metabolic process 5/594 20/18670 0.0003 0.0038 5
GO:0048872 homeostasis of number of cells 19/594 246/18670 0.0004 0.0040 19
GO:0033077 T cell differentiation in thymus 9/594 70/18670 0.0004 0.0042 9
GO:0002697 regulation of immune effector process 29/594 458/18670 0.0004 0.0042 29
GO:1903362 regulation of cellular protein catabolic process 19/594 247/18670 0.0004 0.0042 19
GO:0010543 regulation of platelet activation 6/594 31/18670 0.0004 0.0043 6
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 6/594 31/18670 0.0004 0.0043 6
GO:0031334 positive regulation of protein complex assembly 20/594 268/18670 0.0004 0.0044 20
GO:0006303 double-strand break repair via nonhomologous end joining 10/594 86/18670 0.0004 0.0045 10
GO:0042113 B cell activation 22/594 310/18670 0.0004 0.0046 22
GO:0006323 DNA packaging 17/594 210/18670 0.0004 0.0047 17
GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 8/594 57/18670 0.0004 0.0047 8
GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 8/594 57/18670 0.0004 0.0047 8
GO:0071383 cellular response to steroid hormone stimulus 19/594 250/18670 0.0004 0.0048 19
GO:0048871 multicellular organismal homeostasis 30/594 485/18670 0.0004 0.0048 30
GO:0001659 temperature homeostasis 15/594 173/18670 0.0004 0.0048 15
GO:0009060 aerobic respiration 10/594 87/18670 0.0004 0.0049 10
GO:0009991 response to extracellular stimulus 32/594 531/18670 0.0004 0.0049 32
GO:0035019 somatic stem cell population maintenance 9/594 72/18670 0.0004 0.0050 9
GO:0001819 positive regulation of cytokine production 29/594 464/18670 0.0005 0.0050 29
GO:0043086 negative regulation of catalytic activity 44/594 815/18670 0.0005 0.0050 44
GO:0072522 purine-containing compound biosynthetic process 22/594 313/18670 0.0005 0.0051 22
GO:1902105 regulation of leukocyte differentiation 20/594 272/18670 0.0005 0.0052 20
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 10/594 88/18670 0.0005 0.0052 10
GO:0030968 endoplasmic reticulum unfolded protein response 12/594 121/18670 0.0005 0.0053 12
GO:0048589 developmental growth 38/594 674/18670 0.0005 0.0054 38
GO:0019827 stem cell population maintenance 14/594 157/18670 0.0005 0.0055 14
GO:0007596 blood coagulation 23/594 336/18670 0.0005 0.0055 23
GO:2001020 regulation of response to DNA damage stimulus 17/594 214/18670 0.0005 0.0056 17
GO:0019079 viral genome replication 12/594 122/18670 0.0005 0.0056 12
GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 8/594 59/18670 0.0005 0.0057 8
GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 8/594 59/18670 0.0005 0.0057 8
GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 8/594 59/18670 0.0005 0.0057 8
GO:0030851 granulocyte differentiation 6/594 33/18670 0.0005 0.0058 6
GO:0007063 regulation of sister chromatid cohesion 5/594 22/18670 0.0005 0.0058 5
GO:0070371 ERK1 and ERK2 cascade 22/594 317/18670 0.0005 0.0059 22
GO:0071900 regulation of protein serine/threonine kinase activity 31/594 515/18670 0.0006 0.0059 31
GO:0014015 positive regulation of gliogenesis 9/594 74/18670 0.0006 0.0059 9
GO:1900182 positive regulation of protein localization to nucleus 9/594 74/18670 0.0006 0.0059 9
GO:0031058 positive regulation of histone modification 10/594 90/18670 0.0006 0.0061 10
GO:0009162 deoxyribonucleoside monophosphate metabolic process 4/594 13/18670 0.0006 0.0061 4
GO:0009156 ribonucleoside monophosphate biosynthetic process 16/594 197/18670 0.0006 0.0062 16
GO:0090090 negative regulation of canonical Wnt signaling pathway 15/594 178/18670 0.0006 0.0062 15
GO:0009167 purine ribonucleoside monophosphate metabolic process 23/594 340/18670 0.0006 0.0062 23
GO:0045576 mast cell activation 8/594 60/18670 0.0006 0.0063 8
GO:0008406 gonad development 17/594 217/18670 0.0006 0.0063 17
GO:0009141 nucleoside triphosphate metabolic process 24/594 362/18670 0.0006 0.0063 24
GO:0046661 male sex differentiation 14/594 160/18670 0.0006 0.0063 14
GO:0009126 purine nucleoside monophosphate metabolic process 23/594 341/18670 0.0006 0.0064 23
GO:0006611 protein export from nucleus 15/594 179/18670 0.0006 0.0064 15
GO:0030177 positive regulation of Wnt signaling pathway 15/594 179/18670 0.0006 0.0064 15
GO:0010001 glial cell differentiation 17/594 218/18670 0.0006 0.0066 17
GO:0042692 muscle cell differentiation 25/594 385/18670 0.0006 0.0066 25
GO:0050817 coagulation 23/594 342/18670 0.0006 0.0066 23
GO:0070372 regulation of ERK1 and ERK2 cascade 21/594 300/18670 0.0007 0.0067 21
GO:0051402 neuron apoptotic process 18/594 239/18670 0.0007 0.0068 18
GO:0070302 regulation of stress-activated protein kinase signaling cascade 18/594 239/18670 0.0007 0.0068 18
GO:2000116 regulation of cysteine-type endopeptidase activity 18/594 239/18670 0.0007 0.0068 18
GO:0007064 mitotic sister chromatid cohesion 5/594 23/18670 0.0007 0.0068 5
GO:0048714 positive regulation of oligodendrocyte differentiation 5/594 23/18670 0.0007 0.0068 5
GO:2000637 positive regulation of gene silencing by miRNA 5/594 23/18670 0.0007 0.0068 5
GO:0000380 alternative mRNA splicing, via spliceosome 9/594 76/18670 0.0007 0.0068 9
GO:0048608 reproductive structure development 27/594 431/18670 0.0007 0.0069 27
GO:0010498 proteasomal protein catabolic process 29/594 477/18670 0.0007 0.0071 29
GO:0009166 nucleotide catabolic process 15/594 182/18670 0.0007 0.0075 15
GO:0042593 glucose homeostasis 18/594 241/18670 0.0007 0.0075 18
GO:0002694 regulation of leukocyte activation 33/594 571/18670 0.0007 0.0075 33
GO:0006101 citrate metabolic process 6/594 35/18670 0.0007 0.0075 6
GO:0006369 termination of RNA polymerase II transcription 6/594 35/18670 0.0007 0.0075 6
GO:0009262 deoxyribonucleotide metabolic process 6/594 35/18670 0.0007 0.0075 6
GO:0061458 reproductive system development 27/594 434/18670 0.0008 0.0075 27
GO:0032648 regulation of interferon-beta production 7/594 48/18670 0.0008 0.0075 7
GO:0051972 regulation of telomerase activity 7/594 48/18670 0.0008 0.0075 7
GO:0061647 histone H3-K9 modification 7/594 48/18670 0.0008 0.0075 7
GO:1903727 positive regulation of phospholipid metabolic process 7/594 48/18670 0.0008 0.0075 7
GO:0010466 negative regulation of peptidase activity 19/594 262/18670 0.0008 0.0075 19
GO:0006412 translation 39/594 714/18670 0.0008 0.0075 39
GO:0033500 carbohydrate homeostasis 18/594 242/18670 0.0008 0.0076 18
GO:0035821 modification of morphology or physiology of other organism 14/594 164/18670 0.0008 0.0076 14
GO:0043043 peptide biosynthetic process 40/594 739/18670 0.0008 0.0077 40
GO:0061136 regulation of proteasomal protein catabolic process 15/594 183/18670 0.0008 0.0077 15
GO:0033674 positive regulation of kinase activity 33/594 573/18670 0.0008 0.0078 33
GO:0000726 non-recombinational repair 10/594 94/18670 0.0008 0.0079 10
GO:0044728 DNA methylation or demethylation 10/594 94/18670 0.0008 0.0079 10
GO:0045137 development of primary sexual characteristics 17/594 223/18670 0.0008 0.0080 17
GO:1904019 epithelial cell apoptotic process 11/594 111/18670 0.0008 0.0080 11
GO:0048017 inositol lipid-mediated signaling 15/594 184/18670 0.0008 0.0080 15
GO:0060148 positive regulation of posttranscriptional gene silencing 5/594 24/18670 0.0008 0.0080 5
GO:0098609 cell-cell adhesion 44/594 839/18670 0.0008 0.0080 44
GO:0031571 mitotic G1 DNA damage checkpoint 8/594 63/18670 0.0008 0.0080 8
GO:0044819 mitotic G1/S transition checkpoint 8/594 63/18670 0.0008 0.0080 8
GO:0015980 energy derivation by oxidation of organic compounds 20/594 285/18670 0.0008 0.0081 20
GO:0002262 myeloid cell homeostasis 13/594 147/18670 0.0009 0.0082 13
GO:1901657 glycosyl compound metabolic process 13/594 147/18670 0.0009 0.0082 13
GO:0018022 peptidyl-lysine methylation 12/594 129/18670 0.0009 0.0082 12
GO:0097435 supramolecular fiber organization 37/594 671/18670 0.0009 0.0083 37
GO:1903708 positive regulation of hemopoiesis 15/594 185/18670 0.0009 0.0083 15
GO:0051973 positive regulation of telomerase activity 6/594 36/18670 0.0009 0.0083 6
GO:0045069 regulation of viral genome replication 10/594 95/18670 0.0009 0.0083 10
GO:0051651 maintenance of location in cell 10/594 95/18670 0.0009 0.0083 10
GO:0002440 production of molecular mediator of immune response 20/594 286/18670 0.0009 0.0083 20
GO:0050867 positive regulation of cell activation 25/594 394/18670 0.0009 0.0084 25
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 11/594 112/18670 0.0009 0.0084 11
GO:0019693 ribose phosphate metabolic process 33/594 577/18670 0.0009 0.0084 33
GO:0030193 regulation of blood coagulation 9/594 79/18670 0.0009 0.0084 9
GO:0022900 electron transport chain 15/594 186/18670 0.0009 0.0086 15
GO:0016445 somatic diversification of immunoglobulins 8/594 64/18670 0.0009 0.0086 8
GO:0036498 IRE1-mediated unfolded protein response 8/594 64/18670 0.0009 0.0086 8
GO:0043550 regulation of lipid kinase activity 8/594 64/18670 0.0009 0.0086 8
GO:0044783 G1 DNA damage checkpoint 8/594 64/18670 0.0009 0.0086 8
GO:2000378 negative regulation of reactive oxygen species metabolic process 8/594 64/18670 0.0009 0.0086 8
GO:0045860 positive regulation of protein kinase activity 31/594 532/18670 0.0009 0.0087 31
GO:0034404 nucleobase-containing small molecule biosynthetic process 17/594 226/18670 0.0009 0.0088 17
GO:0043200 response to amino acid 11/594 113/18670 0.0010 0.0088 11
GO:0060964 regulation of gene silencing by miRNA 11/594 113/18670 0.0010 0.0088 11
GO:0009267 cellular response to starvation 13/594 149/18670 0.0010 0.0089 13
GO:0032787 monocarboxylic acid metabolic process 36/594 651/18670 0.0010 0.0089 36
GO:0032608 interferon-beta production 7/594 50/18670 0.0010 0.0089 7
GO:1900046 regulation of hemostasis 9/594 80/18670 0.0010 0.0090 9
GO:0098754 detoxification 12/594 131/18670 0.0010 0.0090 12
GO:0051604 protein maturation 25/594 397/18670 0.0010 0.0090 25
GO:0031668 cellular response to extracellular stimulus 19/594 268/18670 0.0010 0.0091 19
GO:0007339 binding of sperm to zona pellucida 6/594 37/18670 0.0010 0.0092 6
GO:0051567 histone H3-K9 methylation 6/594 37/18670 0.0010 0.0092 6
GO:0031060 regulation of histone methylation 8/594 65/18670 0.0010 0.0093 8
GO:1901292 nucleoside phosphate catabolic process 15/594 188/18670 0.0010 0.0093 15
GO:0051346 negative regulation of hydrolase activity 28/594 466/18670 0.0010 0.0094 28
GO:0030518 intracellular steroid hormone receptor signaling pathway 12/594 132/18670 0.0010 0.0094 12
GO:0009415 response to water 4/594 15/18670 0.0010 0.0094 4
GO:0030812 negative regulation of nucleotide catabolic process 4/594 15/18670 0.0010 0.0094 4
GO:0034349 glial cell apoptotic process 4/594 15/18670 0.0010 0.0094 4
GO:0051198 negative regulation of coenzyme metabolic process 4/594 15/18670 0.0010 0.0094 4
GO:0000819 sister chromatid segregation 15/594 189/18670 0.0011 0.0097 15
GO:0006959 humoral immune response 23/594 356/18670 0.0011 0.0099 23
GO:0042770 signal transduction in response to DNA damage 12/594 133/18670 0.0011 0.0100 12

C (501 terms)

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0002366 leukocyte activation involved in immune response 60/300 707/18670 0.0000 0.0000 60
GO:0002263 cell activation involved in immune response 60/300 711/18670 0.0000 0.0000 60
GO:0002274 myeloid leukocyte activation 57/300 651/18670 0.0000 0.0000 57
GO:0036230 granulocyte activation 48/300 504/18670 0.0000 0.0000 48
GO:0042119 neutrophil activation 47/300 498/18670 0.0000 0.0000 47
GO:0043299 leukocyte degranulation 48/300 534/18670 0.0000 0.0000 48
GO:0006887 exocytosis 61/300 903/18670 0.0000 0.0000 61
GO:0043312 neutrophil degranulation 45/300 485/18670 0.0000 0.0000 45
GO:0002283 neutrophil activation involved in immune response 45/300 488/18670 0.0000 0.0000 45
GO:0002275 myeloid cell activation involved in immune response 47/300 544/18670 0.0000 0.0000 47
GO:0002446 neutrophil mediated immunity 45/300 499/18670 0.0000 0.0000 45
GO:0002444 myeloid leukocyte mediated immunity 47/300 551/18670 0.0000 0.0000 47
GO:0045055 regulated exocytosis 56/300 794/18670 0.0000 0.0000 56
GO:0002443 leukocyte mediated immunity 56/300 874/18670 0.0000 0.0000 56
GO:0019221 cytokine-mediated signaling pathway 46/300 798/18670 0.0000 0.0000 46
GO:0097190 apoptotic signaling pathway 38/300 602/18670 0.0000 0.0000 38
GO:2001233 regulation of apoptotic signaling pathway 30/300 406/18670 0.0000 0.0000 30
GO:0001816 cytokine production 42/300 790/18670 0.0000 0.0000 42
GO:0043066 negative regulation of apoptotic process 45/300 911/18670 0.0000 0.0000 45
GO:0043069 negative regulation of programmed cell death 45/300 932/18670 0.0000 0.0000 45
GO:0014070 response to organic cyclic compound 44/300 915/18670 0.0000 0.0000 44
GO:0050865 regulation of cell activation 35/300 614/18670 0.0000 0.0000 35
GO:0002520 immune system development 45/300 985/18670 0.0000 0.0000 45
GO:0048534 hematopoietic or lymphoid organ development 43/300 929/18670 0.0000 0.0000 43
GO:0001817 regulation of cytokine production 37/300 719/18670 0.0000 0.0000 37
GO:0032870 cellular response to hormone stimulus 36/300 701/18670 0.0000 0.0000 36
GO:0002285 lymphocyte activation involved in immune response 18/300 181/18670 0.0000 0.0000 18
GO:0002694 regulation of leukocyte activation 32/300 571/18670 0.0000 0.0000 32
GO:0030097 hemopoiesis 41/300 887/18670 0.0000 0.0000 41
GO:0010942 positive regulation of cell death 36/300 730/18670 0.0000 0.0000 36
GO:0001818 negative regulation of cytokine production 22/300 296/18670 0.0000 0.0000 22
GO:0043065 positive regulation of apoptotic process 34/300 672/18670 0.0000 0.0000 34
GO:0043068 positive regulation of programmed cell death 34/300 680/18670 0.0000 0.0000 34
GO:0050867 positive regulation of cell activation 25/300 394/18670 0.0000 0.0000 25
GO:2001234 negative regulation of apoptotic signaling pathway 19/300 230/18670 0.0000 0.0000 19
GO:0051050 positive regulation of transport 42/300 982/18670 0.0000 0.0000 42
GO:0002700 regulation of production of molecular mediator of immune response 15/300 139/18670 0.0000 0.0000 15
GO:0009725 response to hormone 42/300 987/18670 0.0000 0.0000 42
GO:0046649 lymphocyte activation 35/300 733/18670 0.0000 0.0000 35
GO:0010035 response to inorganic substance 30/300 562/18670 0.0000 0.0000 30
GO:0033993 response to lipid 40/300 923/18670 0.0000 0.0000 40
GO:0002521 leukocyte differentiation 28/300 515/18670 0.0000 0.0000 28
GO:1903047 mitotic cell cycle process 38/300 873/18670 0.0000 0.0000 38
GO:0044403 symbiont process 38/300 884/18670 0.0000 0.0000 38
GO:0071222 cellular response to lipopolysaccharide 17/300 205/18670 0.0000 0.0000 17
GO:0051098 regulation of binding 23/300 373/18670 0.0000 0.0000 23
GO:0023014 signal transduction by protein phosphorylation 40/300 969/18670 0.0000 0.0000 40
GO:0019725 cellular homeostasis 40/300 970/18670 0.0000 0.0000 40
GO:0044419 interspecies interaction between organisms 39/300 932/18670 0.0000 0.0000 39
GO:0070997 neuron death 22/300 348/18670 0.0000 0.0000 22
GO:0002696 positive regulation of leukocyte activation 23/300 380/18670 0.0000 0.0000 23
GO:1903706 regulation of hemopoiesis 26/300 475/18670 0.0000 0.0000 26
GO:0007568 aging 21/300 321/18670 0.0000 0.0000 21
GO:0071219 cellular response to molecule of bacterial origin 17/300 212/18670 0.0000 0.0000 17
GO:0016032 viral process 36/300 833/18670 0.0000 0.0000 36
GO:0030099 myeloid cell differentiation 24/300 416/18670 0.0000 0.0000 24
GO:0000122 negative regulation of transcription by RNA polymerase II 36/300 839/18670 0.0000 0.0000 36
GO:0030155 regulation of cell adhesion 32/300 691/18670 0.0000 0.0000 32
GO:0000165 MAPK cascade 39/300 958/18670 0.0000 0.0000 39
GO:0010243 response to organonitrogen compound 40/300 998/18670 0.0000 0.0000 40
GO:0032496 response to lipopolysaccharide 21/300 330/18670 0.0000 0.0000 21
GO:0007584 response to nutrient 17/300 219/18670 0.0000 0.0000 17
GO:0006954 inflammatory response 36/300 848/18670 0.0000 0.0000 36
GO:0010038 response to metal ion 22/300 364/18670 0.0000 0.0000 22
GO:0051338 regulation of transferase activity 39/300 972/18670 0.0000 0.0000 39
GO:0007159 leukocyte cell-cell adhesion 21/300 337/18670 0.0000 0.0000 21
GO:0002683 negative regulation of immune system process 25/300 463/18670 0.0000 0.0000 25
GO:0002576 platelet degranulation 13/300 128/18670 0.0000 0.0000 13
GO:0050778 positive regulation of immune response 37/300 902/18670 0.0000 0.0000 37
GO:0046916 cellular transition metal ion homeostasis 12/300 108/18670 0.0000 0.0000 12
GO:1901214 regulation of neuron death 20/300 313/18670 0.0000 0.0000 20
GO:0002237 response to molecule of bacterial origin 21/300 343/18670 0.0000 0.0000 21
GO:0040007 growth 39/300 986/18670 0.0000 0.0000 39
GO:0008284 positive regulation of cell proliferation 38/300 951/18670 0.0000 0.0000 38
GO:0097193 intrinsic apoptotic signaling pathway 19/300 289/18670 0.0000 0.0000 19
GO:0030003 cellular cation homeostasis 30/300 652/18670 0.0000 0.0000 30
GO:0007346 regulation of mitotic cell cycle 30/300 656/18670 0.0000 0.0000 30
GO:0071216 cellular response to biotic stimulus 17/300 236/18670 0.0000 0.0000 17
GO:0044772 mitotic cell cycle phase transition 28/300 588/18670 0.0000 0.0000 28
GO:0051249 regulation of lymphocyte activation 25/300 485/18670 0.0000 0.0000 25
GO:0006873 cellular ion homeostasis 30/300 665/18670 0.0000 0.0000 30
GO:0070661 leukocyte proliferation 19/300 298/18670 0.0000 0.0000 19
GO:0044770 cell cycle phase transition 29/300 631/18670 0.0000 0.0000 29
GO:0070482 response to oxygen levels 22/300 394/18670 0.0000 0.0000 22
GO:0032943 mononuclear cell proliferation 18/300 274/18670 0.0000 0.0000 18
GO:1902532 negative regulation of intracellular signal transduction 27/300 566/18670 0.0000 0.0000 27
GO:0051186 cofactor metabolic process 28/300 602/18670 0.0000 0.0000 28
GO:0001819 positive regulation of cytokine production 24/300 464/18670 0.0000 0.0000 24
GO:0050900 leukocyte migration 25/300 499/18670 0.0000 0.0000 25
GO:0055094 response to lipoprotein particle 7/300 32/18670 0.0000 0.0000 7
GO:0071901 negative regulation of protein serine/threonine kinase activity 13/300 145/18670 0.0000 0.0000 13
GO:1905477 positive regulation of protein localization to membrane 12/300 122/18670 0.0000 0.0000 12
GO:0071396 cellular response to lipid 28/300 610/18670 0.0000 0.0000 28
GO:0045637 regulation of myeloid cell differentiation 17/300 251/18670 0.0000 0.0000 17
GO:0002637 regulation of immunoglobulin production 9/300 63/18670 0.0000 0.0000 9
GO:2000379 positive regulation of reactive oxygen species metabolic process 11/300 102/18670 0.0000 0.0000 11
GO:0055080 cation homeostasis 31/300 730/18670 0.0000 0.0000 31
GO:1901990 regulation of mitotic cell cycle phase transition 23/300 444/18670 0.0000 0.0000 23
GO:0010507 negative regulation of autophagy 10/300 84/18670 0.0000 0.0000 10
GO:0071402 cellular response to lipoprotein particle stimulus 7/300 34/18670 0.0000 0.0000 7
GO:1901987 regulation of cell cycle phase transition 24/300 480/18670 0.0000 0.0000 24
GO:0071900 regulation of protein serine/threonine kinase activity 25/300 515/18670 0.0000 0.0000 25
GO:0055082 cellular chemical homeostasis 33/300 812/18670 0.0000 0.0000 33
GO:0043086 negative regulation of catalytic activity 33/300 815/18670 0.0000 0.0000 33
GO:0002573 myeloid leukocyte differentiation 15/300 204/18670 0.0000 0.0000 15
GO:0006979 response to oxidative stress 23/300 451/18670 0.0000 0.0001 23
GO:0098771 inorganic ion homeostasis 31/300 741/18670 0.0000 0.0001 31
GO:2001236 regulation of extrinsic apoptotic signaling pathway 13/300 155/18670 0.0000 0.0001 13
GO:0055076 transition metal ion homeostasis 12/300 131/18670 0.0000 0.0001 12
GO:1901215 negative regulation of neuron death 15/300 208/18670 0.0000 0.0001 15
GO:1900407 regulation of cellular response to oxidative stress 10/300 88/18670 0.0000 0.0001 10
GO:2000116 regulation of cysteine-type endopeptidase activity 16/300 239/18670 0.0000 0.0001 16
GO:0043302 positive regulation of leukocyte degranulation 6/300 24/18670 0.0000 0.0001 6
GO:0009991 response to extracellular stimulus 25/300 531/18670 0.0000 0.0001 25
GO:0006914 autophagy 24/300 496/18670 0.0000 0.0001 24
GO:0061919 process utilizing autophagic mechanism 24/300 496/18670 0.0000 0.0001 24
GO:1903708 positive regulation of hemopoiesis 14/300 185/18670 0.0000 0.0001 14
GO:0098609 cell-cell adhesion 33/300 839/18670 0.0000 0.0001 33
GO:0034599 cellular response to oxidative stress 18/300 302/18670 0.0000 0.0001 18
GO:0046651 lymphocyte proliferation 17/300 272/18670 0.0000 0.0001 17
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/300 215/18670 0.0000 0.0001 15
GO:0002699 positive regulation of immune effector process 15/300 216/18670 0.0000 0.0001 15
GO:0071407 cellular response to organic cyclic compound 25/300 542/18670 0.0000 0.0001 25
GO:0045785 positive regulation of cell adhesion 21/300 403/18670 0.0000 0.0001 21
GO:1903039 positive regulation of leukocyte cell-cell adhesion 15/300 218/18670 0.0000 0.0001 15
GO:0031400 negative regulation of protein modification process 27/300 618/18670 0.0000 0.0001 27
GO:0009895 negative regulation of catabolic process 18/300 308/18670 0.0000 0.0001 18
GO:2001242 regulation of intrinsic apoptotic signaling pathway 13/300 165/18670 0.0000 0.0001 13
GO:0050801 ion homeostasis 32/300 811/18670 0.0000 0.0001 32
GO:0009617 response to bacterium 29/300 699/18670 0.0000 0.0001 29
GO:0070663 regulation of leukocyte proliferation 15/300 222/18670 0.0000 0.0001 15
GO:0030316 osteoclast differentiation 10/300 97/18670 0.0000 0.0001 10
GO:1902882 regulation of response to oxidative stress 10/300 97/18670 0.0000 0.0001 10
GO:0097191 extrinsic apoptotic signaling pathway 15/300 224/18670 0.0000 0.0001 15
GO:0002685 regulation of leukocyte migration 14/300 196/18670 0.0000 0.0001 14
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 6/300 27/18670 0.0000 0.0001 6
GO:1902107 positive regulation of leukocyte differentiation 12/300 144/18670 0.0000 0.0001 12
GO:0045089 positive regulation of innate immune response 20/300 381/18670 0.0000 0.0001 20
GO:1901652 response to peptide 24/300 520/18670 0.0000 0.0001 24
GO:0002440 production of molecular mediator of immune response 17/300 286/18670 0.0000 0.0001 17
GO:0051051 negative regulation of transport 24/300 522/18670 0.0000 0.0001 24
GO:0010564 regulation of cell cycle process 31/300 789/18670 0.0000 0.0001 31
GO:0045088 regulation of innate immune response 22/300 452/18670 0.0000 0.0001 22
GO:0043549 regulation of kinase activity 33/300 870/18670 0.0000 0.0001 33
GO:0045859 regulation of protein kinase activity 31/300 792/18670 0.0000 0.0001 31
GO:0002764 immune response-regulating signaling pathway 28/300 675/18670 0.0000 0.0001 28
GO:0042089 cytokine biosynthetic process 11/300 123/18670 0.0000 0.0002 11
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/300 43/18670 0.0000 0.0002 7
GO:0043062 extracellular structure organization 21/300 422/18670 0.0000 0.0002 21
GO:0009611 response to wounding 28/300 678/18670 0.0000 0.0002 28
GO:0042107 cytokine metabolic process 11/300 124/18670 0.0000 0.0002 11
GO:0051101 regulation of DNA binding 11/300 124/18670 0.0000 0.0002 11
GO:0040008 regulation of growth 28/300 679/18670 0.0000 0.0002 28
GO:0002697 regulation of immune effector process 22/300 458/18670 0.0000 0.0002 22
GO:0052548 regulation of endopeptidase activity 21/300 425/18670 0.0000 0.0002 21
GO:0031330 negative regulation of cellular catabolic process 16/300 264/18670 0.0000 0.0002 16
GO:0010506 regulation of autophagy 18/300 327/18670 0.0000 0.0002 18
GO:0042110 T cell activation 22/300 464/18670 0.0000 0.0002 22
GO:2001235 positive regulation of apoptotic signaling pathway 13/300 179/18670 0.0000 0.0002 13
GO:0071887 leukocyte apoptotic process 10/300 104/18670 0.0000 0.0002 10
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 10/300 104/18670 0.0000 0.0002 10
GO:0050878 regulation of body fluid levels 23/300 501/18670 0.0000 0.0002 23
GO:0034394 protein localization to cell surface 8/300 63/18670 0.0000 0.0002 8
GO:0051090 regulation of DNA-binding transcription factor activity 21/300 432/18670 0.0000 0.0002 21
GO:0055065 metal ion homeostasis 27/300 653/18670 0.0000 0.0002 27
GO:0051046 regulation of secretion 31/300 811/18670 0.0000 0.0002 31
GO:0032944 regulation of mononuclear cell proliferation 14/300 209/18670 0.0000 0.0002 14
GO:0006875 cellular metal ion homeostasis 25/300 579/18670 0.0000 0.0002 25
GO:0033002 muscle cell proliferation 15/300 239/18670 0.0000 0.0002 15
GO:0006974 cellular response to DNA damage stimulus 32/300 854/18670 0.0000 0.0002 32
GO:0043300 regulation of leukocyte degranulation 7/300 46/18670 0.0000 0.0002 7
GO:0006826 iron ion transport 8/300 64/18670 0.0000 0.0002 8
GO:0051251 positive regulation of lymphocyte activation 18/300 334/18670 0.0000 0.0002 18
GO:0043434 response to peptide hormone 21/300 436/18670 0.0000 0.0002 21
GO:0031347 regulation of defense response 33/300 901/18670 0.0000 0.0002 33
GO:1903037 regulation of leukocyte cell-cell adhesion 17/300 304/18670 0.0000 0.0002 17
GO:0036293 response to decreased oxygen levels 19/300 370/18670 0.0000 0.0002 19
GO:0006897 endocytosis 31/300 820/18670 0.0000 0.0002 31
GO:0032930 positive regulation of superoxide anion generation 5/300 19/18670 0.0000 0.0003 5
GO:0045921 positive regulation of exocytosis 9/300 88/18670 0.0000 0.0003 9
GO:0016049 cell growth 22/300 484/18670 0.0000 0.0003 22
GO:0060759 regulation of response to cytokine stimulus 13/300 190/18670 0.0000 0.0003 13
GO:1903530 regulation of secretion by cell 29/300 753/18670 0.0000 0.0003 29
GO:0052547 regulation of peptidase activity 21/300 452/18670 0.0000 0.0004 21
GO:0031098 stress-activated protein kinase signaling cascade 17/300 315/18670 0.0000 0.0004 17
GO:0072593 reactive oxygen species metabolic process 16/300 284/18670 0.0000 0.0004 16
GO:0051348 negative regulation of transferase activity 16/300 285/18670 0.0000 0.0004 16
GO:0022409 positive regulation of cell-cell adhesion 15/300 255/18670 0.0000 0.0004 15
GO:0002218 activation of innate immune response 17/300 319/18670 0.0000 0.0004 17
GO:0030098 lymphocyte differentiation 18/300 353/18670 0.0000 0.0004 18
GO:0002701 negative regulation of production of molecular mediator of immune response 6/300 35/18670 0.0000 0.0004 6
GO:0031589 cell-substrate adhesion 18/300 354/18670 0.0000 0.0004 18
GO:0036473 cell death in response to oxidative stress 9/300 93/18670 0.0000 0.0004 9
GO:0033673 negative regulation of kinase activity 15/300 257/18670 0.0000 0.0004 15
GO:0048660 regulation of smooth muscle cell proliferation 12/300 169/18670 0.0000 0.0004 12
GO:0051100 negative regulation of binding 12/300 169/18670 0.0000 0.0004 12
GO:0002761 regulation of myeloid leukocyte differentiation 10/300 117/18670 0.0000 0.0005 10
GO:0019852 L-ascorbic acid metabolic process 4/300 11/18670 0.0000 0.0005 4
GO:0045628 regulation of T-helper 2 cell differentiation 4/300 11/18670 0.0000 0.0005 4
GO:0009894 regulation of catabolic process 34/300 979/18670 0.0000 0.0005 34
GO:0031667 response to nutrient levels 22/300 499/18670 0.0000 0.0005 22
GO:1903307 positive regulation of regulated secretory pathway 7/300 53/18670 0.0000 0.0005 7
GO:0010742 macrophage derived foam cell differentiation 6/300 36/18670 0.0000 0.0005 6
GO:0033572 transferrin transport 6/300 36/18670 0.0000 0.0005 6
GO:0090077 foam cell differentiation 6/300 36/18670 0.0000 0.0005 6
GO:0090322 regulation of superoxide metabolic process 6/300 36/18670 0.0000 0.0005 6
GO:0097242 amyloid-beta clearance 6/300 36/18670 0.0000 0.0005 6
GO:0051047 positive regulation of secretion 20/300 428/18670 0.0000 0.0005 20
GO:0048659 smooth muscle cell proliferation 12/300 171/18670 0.0000 0.0005 12
GO:0032928 regulation of superoxide anion generation 5/300 22/18670 0.0000 0.0005 5
GO:0071404 cellular response to low-density lipoprotein particle stimulus 5/300 22/18670 0.0000 0.0005 5
GO:0002312 B cell activation involved in immune response 8/300 73/18670 0.0000 0.0005 8
GO:0002702 positive regulation of production of molecular mediator of immune response 9/300 95/18670 0.0000 0.0005 9
GO:0042100 B cell proliferation 9/300 95/18670 0.0000 0.0005 9
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 11/300 145/18670 0.0000 0.0005 11
GO:0070848 response to growth factor 28/300 736/18670 0.0000 0.0005 28
GO:0002703 regulation of leukocyte mediated immunity 13/300 201/18670 0.0000 0.0005 13
GO:0050870 positive regulation of T cell activation 13/300 202/18670 0.0000 0.0005 13
GO:1903201 regulation of oxidative stress-induced cell death 8/300 75/18670 0.0000 0.0006 8
GO:0051272 positive regulation of cellular component movement 24/300 585/18670 0.0000 0.0006 24
GO:0002758 innate immune response-activating signal transduction 16/300 298/18670 0.0000 0.0006 16
GO:0045936 negative regulation of phosphate metabolic process 24/300 586/18670 0.0000 0.0006 24
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 9/300 98/18670 0.0000 0.0006 9
GO:0006469 negative regulation of protein kinase activity 14/300 235/18670 0.0000 0.0006 14
GO:0071888 macrophage apoptotic process 4/300 12/18670 0.0000 0.0006 4
GO:0010563 negative regulation of phosphorus metabolic process 24/300 587/18670 0.0000 0.0006 24
GO:0015682 ferric iron transport 6/300 38/18670 0.0000 0.0006 6
GO:0072512 trivalent inorganic cation transport 6/300 38/18670 0.0000 0.0006 6
GO:0022407 regulation of cell-cell adhesion 19/300 403/18670 0.0000 0.0006 19
GO:0030198 extracellular matrix organization 18/300 368/18670 0.0000 0.0006 18
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 14/300 237/18670 0.0000 0.0006 14
GO:0009117 nucleotide metabolic process 27/300 709/18670 0.0000 0.0006 27
GO:0007249 I-kappaB kinase/NF-kappaB signaling 15/300 269/18670 0.0000 0.0006 15
GO:0050670 regulation of lymphocyte proliferation 13/300 208/18670 0.0000 0.0007 13
GO:0051402 neuron apoptotic process 14/300 239/18670 0.0000 0.0007 14
GO:0043534 blood vessel endothelial cell migration 12/300 180/18670 0.0000 0.0007 12
GO:0048661 positive regulation of smooth muscle cell proliferation 9/300 101/18670 0.0000 0.0007 9
GO:1902105 regulation of leukocyte differentiation 15/300 272/18670 0.0000 0.0007 15
GO:0043523 regulation of neuron apoptotic process 13/300 210/18670 0.0000 0.0007 13
GO:0006753 nucleoside phosphate metabolic process 27/300 716/18670 0.0000 0.0007 27
GO:0031663 lipopolysaccharide-mediated signaling pathway 7/300 58/18670 0.0000 0.0007 7
GO:0019216 regulation of lipid metabolic process 19/300 410/18670 0.0000 0.0007 19
GO:0031349 positive regulation of defense response 22/300 521/18670 0.0000 0.0007 22
GO:0043536 positive regulation of blood vessel endothelial cell migration 8/300 79/18670 0.0000 0.0007 8
GO:0007599 hemostasis 17/300 341/18670 0.0000 0.0008 17
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 27/300 719/18670 0.0000 0.0008 27
GO:0002719 negative regulation of cytokine production involved in immune response 5/300 25/18670 0.0000 0.0008 5
GO:1903827 regulation of cellular protein localization 22/300 524/18670 0.0000 0.0008 22
GO:0002757 immune response-activating signal transduction 25/300 641/18670 0.0000 0.0008 25
GO:0009636 response to toxic substance 22/300 525/18670 0.0000 0.0008 22
GO:0042113 B cell activation 16/300 310/18670 0.0000 0.0008 16
GO:0048872 homeostasis of number of cells 14/300 246/18670 0.0000 0.0009 14
GO:0043408 regulation of MAPK cascade 28/300 768/18670 0.0000 0.0009 28
GO:1905475 regulation of protein localization to membrane 12/300 187/18670 0.0001 0.0009 12
GO:0050863 regulation of T cell activation 16/300 314/18670 0.0001 0.0009 16
GO:0002286 T cell activation involved in immune response 9/300 106/18670 0.0001 0.0010 9
GO:0006879 cellular iron ion homeostasis 7/300 61/18670 0.0001 0.0010 7
GO:1901653 cellular response to peptide 18/300 385/18670 0.0001 0.0010 18
GO:0048145 regulation of fibroblast proliferation 8/300 83/18670 0.0001 0.0010 8
GO:0002819 regulation of adaptive immune response 11/300 160/18670 0.0001 0.0010 11
GO:0002523 leukocyte migration involved in inflammatory response 4/300 14/18670 0.0001 0.0010 4
GO:0045064 T-helper 2 cell differentiation 4/300 14/18670 0.0001 0.0010 4
GO:0098657 import into cell 32/300 945/18670 0.0001 0.0010 32
GO:0002705 positive regulation of leukocyte mediated immunity 10/300 133/18670 0.0001 0.0010 10
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 7/300 62/18670 0.0001 0.0010 7
GO:0016444 somatic cell DNA recombination 7/300 62/18670 0.0001 0.0010 7
GO:0002718 regulation of cytokine production involved in immune response 8/300 84/18670 0.0001 0.0010 8
GO:0048144 fibroblast proliferation 8/300 84/18670 0.0001 0.0010 8
GO:0045597 positive regulation of cell differentiation 33/300 991/18670 0.0001 0.0010 33
GO:0000188 inactivation of MAPK activity 5/300 27/18670 0.0001 0.0011 5
GO:0060341 regulation of cellular localization 31/300 906/18670 0.0001 0.0011 31
GO:0030334 regulation of cell migration 32/300 950/18670 0.0001 0.0011 32
GO:0051403 stress-activated MAPK cascade 15/300 286/18670 0.0001 0.0011 15
GO:0046686 response to cadmium ion 7/300 63/18670 0.0001 0.0011 7
GO:0051924 regulation of calcium ion transport 14/300 254/18670 0.0001 0.0011 14
GO:0043112 receptor metabolic process 12/300 192/18670 0.0001 0.0011 12
GO:0051170 import into nucleus 11/300 163/18670 0.0001 0.0011 11
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 11/300 163/18670 0.0001 0.0011 11
GO:0071375 cellular response to peptide hormone stimulus 16/300 321/18670 0.0001 0.0011 16
GO:0070542 response to fatty acid 8/300 86/18670 0.0001 0.0012 8
GO:0030335 positive regulation of cell migration 22/300 544/18670 0.0001 0.0012 22
GO:0010959 regulation of metal ion transport 18/300 394/18670 0.0001 0.0012 18
GO:0042326 negative regulation of phosphorylation 20/300 468/18670 0.0001 0.0012 20
GO:0001666 response to hypoxia 17/300 359/18670 0.0001 0.0012 17
GO:0080135 regulation of cellular response to stress 27/300 746/18670 0.0001 0.0012 27
GO:0031623 receptor internalization 9/300 111/18670 0.0001 0.0012 9
GO:0002467 germinal center formation 4/300 15/18670 0.0001 0.0012 4
GO:2000377 regulation of reactive oxygen species metabolic process 12/300 195/18670 0.0001 0.0012 12
GO:0071363 cellular response to growth factor stimulus 26/300 706/18670 0.0001 0.0012 26
GO:0010389 regulation of G2/M transition of mitotic cell cycle 12/300 196/18670 0.0001 0.0013 12
GO:1903532 positive regulation of secretion by cell 18/300 399/18670 0.0001 0.0014 18
GO:0071706 tumor necrosis factor superfamily cytokine production 11/300 168/18670 0.0001 0.0014 11
GO:0071675 regulation of mononuclear cell migration 6/300 46/18670 0.0001 0.0014 6
GO:0032602 chemokine production 8/300 89/18670 0.0001 0.0014 8
GO:0042035 regulation of cytokine biosynthetic process 9/300 114/18670 0.0001 0.0015 9
GO:0030001 metal ion transport 30/300 883/18670 0.0001 0.0015 30
GO:0009411 response to UV 10/300 141/18670 0.0001 0.0015 10
GO:0006732 coenzyme metabolic process 18/300 403/18670 0.0001 0.0015 18
GO:0055086 nucleobase-containing small molecule metabolic process 28/300 801/18670 0.0001 0.0016 28
GO:0097067 cellular response to thyroid hormone stimulus 4/300 16/18670 0.0001 0.0016 4
GO:0044843 cell cycle G1/S phase transition 15/300 298/18670 0.0001 0.0016 15
GO:0016241 regulation of macroautophagy 11/300 171/18670 0.0001 0.0016 11
GO:0006909 phagocytosis 17/300 369/18670 0.0001 0.0016 17
GO:0010743 regulation of macrophage derived foam cell differentiation 5/300 30/18670 0.0001 0.0016 5
GO:0061082 myeloid leukocyte cytokine production 5/300 30/18670 0.0001 0.0016 5
GO:0006606 protein import into nucleus 10/300 143/18670 0.0001 0.0016 10
GO:0040017 positive regulation of locomotion 23/300 598/18670 0.0001 0.0016 23
GO:0045639 positive regulation of myeloid cell differentiation 8/300 91/18670 0.0001 0.0016 8
GO:0060333 interferon-gamma-mediated signaling pathway 8/300 91/18670 0.0001 0.0016 8
GO:0007596 blood coagulation 16/300 336/18670 0.0001 0.0017 16
GO:0002253 activation of immune response 26/300 724/18670 0.0001 0.0017 26
GO:0006935 chemotaxis 24/300 644/18670 0.0001 0.0018 24
GO:0042060 wound healing 22/300 564/18670 0.0001 0.0018 22
GO:0033273 response to vitamin 8/300 93/18670 0.0001 0.0019 8
GO:0002224 toll-like receptor signaling pathway 10/300 146/18670 0.0001 0.0019 10
GO:0042330 taxis 24/300 646/18670 0.0001 0.0019 24
GO:0090087 regulation of peptide transport 26/300 729/18670 0.0001 0.0019 26
GO:0010744 positive regulation of macrophage derived foam cell differentiation 4/300 17/18670 0.0001 0.0019 4
GO:0051897 positive regulation of protein kinase B signaling 11/300 176/18670 0.0001 0.0019 11
GO:1901699 cellular response to nitrogen compound 24/300 648/18670 0.0001 0.0020 24
GO:2000147 positive regulation of cell motility 22/300 568/18670 0.0001 0.0020 22
GO:0001959 regulation of cytokine-mediated signaling pathway 11/300 177/18670 0.0001 0.0020 11
GO:0050817 coagulation 16/300 342/18670 0.0001 0.0020 16
GO:0043542 endothelial cell migration 14/300 273/18670 0.0001 0.0020 14
GO:0051099 positive regulation of binding 11/300 179/18670 0.0002 0.0022 11
GO:0002712 regulation of B cell mediated immunity 6/300 51/18670 0.0002 0.0023 6
GO:0002889 regulation of immunoglobulin mediated immune response 6/300 51/18670 0.0002 0.0023 6
GO:0051169 nuclear transport 16/300 346/18670 0.0002 0.0023 16
GO:0071346 cellular response to interferon-gamma 11/300 180/18670 0.0002 0.0023 11
GO:0071466 cellular response to xenobiotic stimulus 11/300 180/18670 0.0002 0.0023 11
GO:0051223 regulation of protein transport 25/300 699/18670 0.0002 0.0023 25
GO:0016242 negative regulation of macroautophagy 5/300 33/18670 0.0002 0.0023 5
GO:0033028 myeloid cell apoptotic process 5/300 33/18670 0.0002 0.0023 5
GO:0045191 regulation of isotype switching 5/300 33/18670 0.0002 0.0023 5
GO:0031329 regulation of cellular catabolic process 29/300 871/18670 0.0002 0.0024 29
GO:0048545 response to steroid hormone 17/300 385/18670 0.0002 0.0024 17
GO:0016447 somatic recombination of immunoglobulin gene segments 6/300 52/18670 0.0002 0.0024 6
GO:1902749 regulation of cell cycle G2/M phase transition 12/300 213/18670 0.0002 0.0024 12
GO:0000082 G1/S transition of mitotic cell cycle 14/300 279/18670 0.0002 0.0024 14
GO:0070201 regulation of establishment of protein localization 26/300 746/18670 0.0002 0.0026 26
GO:0010631 epithelial cell migration 16/300 351/18670 0.0002 0.0026 16
GO:0043409 negative regulation of MAPK cascade 11/300 184/18670 0.0002 0.0027 11
GO:0045851 pH reduction 6/300 53/18670 0.0002 0.0027 6
GO:1905517 macrophage migration 6/300 53/18670 0.0002 0.0027 6
GO:0002200 somatic diversification of immune receptors 7/300 75/18670 0.0002 0.0027 7
GO:0150076 neuroinflammatory response 7/300 75/18670 0.0002 0.0027 7
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/300 19/18670 0.0002 0.0028 4
GO:0090132 epithelium migration 16/300 354/18670 0.0002 0.0028 16
GO:0071241 cellular response to inorganic substance 12/300 217/18670 0.0002 0.0028 12
GO:0001933 negative regulation of protein phosphorylation 18/300 429/18670 0.0002 0.0028 18
GO:0043535 regulation of blood vessel endothelial cell migration 10/300 156/18670 0.0002 0.0029 10
GO:0002763 positive regulation of myeloid leukocyte differentiation 6/300 54/18670 0.0002 0.0029 6
GO:0043392 negative regulation of DNA binding 6/300 54/18670 0.0002 0.0029 6
GO:0002687 positive regulation of leukocyte migration 9/300 128/18670 0.0002 0.0029 9
GO:0010595 positive regulation of endothelial cell migration 9/300 128/18670 0.0002 0.0029 9
GO:0002367 cytokine production involved in immune response 8/300 102/18670 0.0002 0.0031 8
GO:0048589 developmental growth 24/300 674/18670 0.0002 0.0031 24
GO:0042306 regulation of protein import into nucleus 6/300 55/18670 0.0002 0.0031 6
GO:0040013 negative regulation of locomotion 17/300 396/18670 0.0002 0.0031 17
GO:0090130 tissue migration 16/300 360/18670 0.0003 0.0032 16
GO:1903829 positive regulation of cellular protein localization 15/300 324/18670 0.0003 0.0032 15
GO:0007229 integrin-mediated signaling pathway 8/300 103/18670 0.0003 0.0033 8
GO:0043407 negative regulation of MAP kinase activity 7/300 78/18670 0.0003 0.0033 7
GO:0033194 response to hydroperoxide 4/300 20/18670 0.0003 0.0033 4
GO:0071636 positive regulation of transforming growth factor beta production 4/300 20/18670 0.0003 0.0033 4
GO:0006882 cellular zinc ion homeostasis 5/300 36/18670 0.0003 0.0033 5
GO:0042554 superoxide anion generation 5/300 36/18670 0.0003 0.0033 5
GO:0071248 cellular response to metal ion 11/300 190/18670 0.0003 0.0033 11
GO:0032680 regulation of tumor necrosis factor production 10/300 160/18670 0.0003 0.0033 10
GO:0030183 B cell differentiation 9/300 131/18670 0.0003 0.0033 9
GO:0032946 positive regulation of mononuclear cell proliferation 9/300 131/18670 0.0003 0.0033 9
GO:0098754 detoxification 9/300 131/18670 0.0003 0.0033 9
GO:1903078 positive regulation of protein localization to plasma membrane 6/300 56/18670 0.0003 0.0033 6
GO:1903202 negative regulation of oxidative stress-induced cell death 6/300 56/18670 0.0003 0.0033 6
GO:0046822 regulation of nucleocytoplasmic transport 8/300 104/18670 0.0003 0.0034 8
GO:0017144 drug metabolic process 28/300 851/18670 0.0003 0.0034 28
GO:0055072 iron ion homeostasis 7/300 79/18670 0.0003 0.0034 7
GO:0005996 monosaccharide metabolic process 14/300 292/18670 0.0003 0.0035 14
GO:0009410 response to xenobiotic stimulus 14/300 292/18670 0.0003 0.0035 14
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/300 132/18670 0.0003 0.0035 9
GO:0030212 hyaluronan metabolic process 5/300 37/18670 0.0003 0.0036 5
GO:1900408 negative regulation of cellular response to oxidative stress 6/300 57/18670 0.0003 0.0036 6
GO:0022617 extracellular matrix disassembly 7/300 80/18670 0.0003 0.0036 7
GO:0019882 antigen processing and presentation 12/300 226/18670 0.0003 0.0037 12
GO:0051235 maintenance of location 15/300 330/18670 0.0003 0.0037 15
GO:0032640 tumor necrosis factor production 10/300 163/18670 0.0003 0.0037 10
GO:0016236 macroautophagy 14/300 295/18670 0.0003 0.0038 14
GO:0032355 response to estradiol 9/300 134/18670 0.0003 0.0038 9
GO:0070838 divalent metal ion transport 19/300 483/18670 0.0003 0.0038 19
GO:0034109 homotypic cell-cell adhesion 7/300 81/18670 0.0003 0.0038 7
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/300 58/18670 0.0003 0.0039 6
GO:1904589 regulation of protein import 6/300 58/18670 0.0003 0.0039 6
GO:0035690 cellular response to drug 16/300 369/18670 0.0003 0.0039 16
GO:0001909 leukocyte mediated cytotoxicity 8/300 107/18670 0.0003 0.0039 8
GO:0048524 positive regulation of viral process 8/300 107/18670 0.0003 0.0039 8
GO:0055069 zinc ion homeostasis 5/300 38/18670 0.0003 0.0039 5
GO:0050727 regulation of inflammatory response 19/300 485/18670 0.0003 0.0040 19
GO:0051347 positive regulation of transferase activity 23/300 649/18670 0.0004 0.0041 23
GO:0090068 positive regulation of cell cycle process 14/300 298/18670 0.0004 0.0041 14
GO:1902883 negative regulation of response to oxidative stress 6/300 59/18670 0.0004 0.0042 6
GO:0006790 sulfur compound metabolic process 16/300 372/18670 0.0004 0.0042 16
GO:0006164 purine nucleotide biosynthetic process 14/300 300/18670 0.0004 0.0043 14
GO:0045582 positive regulation of T cell differentiation 7/300 83/18670 0.0004 0.0043 7
GO:0072511 divalent inorganic cation transport 19/300 489/18670 0.0004 0.0043 19
GO:0006925 inflammatory cell apoptotic process 4/300 22/18670 0.0004 0.0043 4
GO:1905521 regulation of macrophage migration 5/300 39/18670 0.0004 0.0043 5
GO:0032101 regulation of response to external stimulus 29/300 913/18670 0.0004 0.0043 29
GO:0034341 response to interferon-gamma 11/300 199/18670 0.0004 0.0044 11
GO:0045930 negative regulation of mitotic cell cycle 15/300 338/18670 0.0004 0.0045 15
GO:0060627 regulation of vesicle-mediated transport 20/300 532/18670 0.0004 0.0046 20
GO:0070665 positive regulation of leukocyte proliferation 9/300 139/18670 0.0004 0.0047 9
GO:0006163 purine nucleotide metabolic process 21/300 575/18670 0.0004 0.0048 21
GO:0001558 regulation of cell growth 17/300 416/18670 0.0004 0.0048 17
GO:0043491 protein kinase B signaling 13/300 269/18670 0.0004 0.0048 13
GO:0043433 negative regulation of DNA-binding transcription factor activity 10/300 170/18670 0.0004 0.0048 10
GO:0009396 folic acid-containing compound biosynthetic process 3/300 10/18670 0.0005 0.0050 3
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 3/300 10/18670 0.0005 0.0050 3
GO:0000041 transition metal ion transport 8/300 112/18670 0.0005 0.0050 8
GO:1990748 cellular detoxification 8/300 112/18670 0.0005 0.0050 8
GO:0000715 nucleotide-excision repair, DNA damage recognition 4/300 23/18670 0.0005 0.0050 4
GO:0010634 positive regulation of epithelial cell migration 10/300 171/18670 0.0005 0.0050 10
GO:0030278 regulation of ossification 11/300 203/18670 0.0005 0.0050 11
GO:0006913 nucleocytoplasmic transport 15/300 343/18670 0.0005 0.0051 15
GO:0008286 insulin receptor signaling pathway 9/300 141/18670 0.0005 0.0051 9
GO:0032623 interleukin-2 production 6/300 62/18670 0.0005 0.0051 6
GO:0046620 regulation of organ growth 8/300 113/18670 0.0005 0.0052 8
GO:0032868 response to insulin 13/300 272/18670 0.0005 0.0052 13
GO:0046637 regulation of alpha-beta T cell differentiation 6/300 63/18670 0.0005 0.0055 6
GO:1904377 positive regulation of protein localization to cell periphery 6/300 63/18670 0.0005 0.0055 6
GO:0030217 T cell differentiation 12/300 240/18670 0.0005 0.0057 12
GO:0071417 cellular response to organonitrogen compound 21/300 585/18670 0.0005 0.0057 21
GO:0071677 positive regulation of mononuclear cell migration 4/300 24/18670 0.0005 0.0057 4
GO:0002639 positive regulation of immunoglobulin production 5/300 42/18670 0.0005 0.0058 5
GO:0009165 nucleotide biosynthetic process 16/300 386/18670 0.0005 0.0058 16
GO:0016445 somatic diversification of immunoglobulins 6/300 64/18670 0.0006 0.0059 6
GO:0045670 regulation of osteoclast differentiation 6/300 64/18670 0.0006 0.0059 6
GO:0050792 regulation of viral process 11/300 208/18670 0.0006 0.0059 11
GO:0061061 muscle structure development 23/300 672/18670 0.0006 0.0060 23
GO:0072522 purine-containing compound biosynthetic process 14/300 313/18670 0.0006 0.0060 14
GO:1900180 regulation of protein localization to nucleus 8/300 116/18670 0.0006 0.0060 8
GO:0051346 negative regulation of hydrolase activity 18/300 466/18670 0.0006 0.0060 18
GO:0008285 negative regulation of cell proliferation 25/300 760/18670 0.0006 0.0061 25
GO:0051701 interaction with host 11/300 209/18670 0.0006 0.0061 11
GO:0045787 positive regulation of cell cycle 16/300 389/18670 0.0006 0.0061 16
GO:1901293 nucleoside phosphate biosynthetic process 16/300 390/18670 0.0006 0.0063 16
GO:0097529 myeloid leukocyte migration 11/300 210/18670 0.0006 0.0063 11
GO:0051896 regulation of protein kinase B signaling 12/300 244/18670 0.0006 0.0063 12
GO:0006898 receptor-mediated endocytosis 14/300 316/18670 0.0006 0.0064 14
GO:0043524 negative regulation of neuron apoptotic process 9/300 147/18670 0.0006 0.0064 9
GO:0045672 positive regulation of osteoclast differentiation 4/300 25/18670 0.0006 0.0064 4
GO:0051156 glucose 6-phosphate metabolic process 4/300 25/18670 0.0006 0.0064 4
GO:2000679 positive regulation of transcription regulatory region DNA binding 4/300 25/18670 0.0006 0.0064 4
GO:0072507 divalent inorganic cation homeostasis 19/300 513/18670 0.0007 0.0069 19
GO:0000086 G2/M transition of mitotic cell cycle 12/300 247/18670 0.0007 0.0069 12
GO:0097237 cellular response to toxic substance 12/300 247/18670 0.0007 0.0069 12
GO:0002706 regulation of lymphocyte mediated immunity 9/300 149/18670 0.0007 0.0070 9
GO:2001056 positive regulation of cysteine-type endopeptidase activity 9/300 149/18670 0.0007 0.0070 9
GO:0006816 calcium ion transport 17/300 434/18670 0.0007 0.0070 17
GO:2000117 negative regulation of cysteine-type endopeptidase activity 7/300 92/18670 0.0007 0.0071 7
GO:0016051 carbohydrate biosynthetic process 11/300 214/18670 0.0007 0.0072 11
GO:0097066 response to thyroid hormone 4/300 26/18670 0.0007 0.0074 4
GO:0001503 ossification 16/300 398/18670 0.0008 0.0075 16
GO:0010951 negative regulation of endopeptidase activity 12/300 250/18670 0.0008 0.0076 12
GO:0032869 cellular response to insulin stimulus 11/300 216/18670 0.0008 0.0077 11
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 15/300 361/18670 0.0008 0.0078 15
GO:0045621 positive regulation of lymphocyte differentiation 7/300 94/18670 0.0008 0.0079 7
GO:0017157 regulation of exocytosis 11/300 217/18670 0.0008 0.0079 11
GO:0043393 regulation of protein binding 11/300 217/18670 0.0008 0.0079 11
GO:0050864 regulation of B cell activation 10/300 184/18670 0.0008 0.0079 10
GO:0042308 negative regulation of protein import into nucleus 3/300 12/18670 0.0008 0.0079 3
GO:1904590 negative regulation of protein import 3/300 12/18670 0.0008 0.0079 3
GO:0045861 negative regulation of proteolysis 15/300 363/18670 0.0008 0.0081 15
GO:0030168 platelet activation 9/300 153/18670 0.0008 0.0082 9
GO:0070227 lymphocyte apoptotic process 6/300 69/18670 0.0008 0.0082 6
GO:0051928 positive regulation of calcium ion transport 8/300 123/18670 0.0008 0.0082 8
GO:0071621 granulocyte chemotaxis 8/300 123/18670 0.0008 0.0082 8
GO:0007162 negative regulation of cell adhesion 13/300 289/18670 0.0008 0.0082 13
GO:0042116 macrophage activation 7/300 95/18670 0.0009 0.0082 7
GO:1903076 regulation of protein localization to plasma membrane 7/300 95/18670 0.0009 0.0082 7
GO:0032673 regulation of interleukin-4 production 4/300 27/18670 0.0009 0.0082 4
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 5/300 47/18670 0.0009 0.0087 5
GO:0002208 somatic diversification of immunoglobulins involved in immune response 5/300 47/18670 0.0009 0.0087 5
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 5/300 47/18670 0.0009 0.0087 5
GO:0045190 isotype switching 5/300 47/18670 0.0009 0.0087 5
GO:0046638 positive regulation of alpha-beta T cell differentiation 5/300 47/18670 0.0009 0.0087 5
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 5/300 47/18670 0.0009 0.0087 5
GO:0030162 regulation of proteolysis 26/300 831/18670 0.0010 0.0090 26
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 11/300 222/18670 0.0010 0.0091 11
GO:0072521 purine-containing compound metabolic process 21/300 613/18670 0.0010 0.0091 21
GO:0042440 pigment metabolic process 6/300 71/18670 0.0010 0.0092 6
GO:0036296 response to increased oxygen levels 4/300 28/18670 0.0010 0.0092 4
GO:0090383 phagosome acidification 4/300 28/18670 0.0010 0.0092 4
GO:0001774 microglial cell activation 5/300 48/18670 0.0010 0.0094 5
GO:0002269 leukocyte activation involved in inflammatory response 5/300 48/18670 0.0010 0.0094 5
GO:0046364 monosaccharide biosynthetic process 7/300 98/18670 0.0010 0.0095 7
GO:0010763 positive regulation of fibroblast migration 3/300 13/18670 0.0010 0.0097 3
GO:0042178 xenobiotic catabolic process 3/300 13/18670 0.0010 0.0097 3
GO:0038034 signal transduction in absence of ligand 6/300 72/18670 0.0011 0.0097 6
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 6/300 72/18670 0.0011 0.0097 6
GO:0007160 cell-matrix adhesion 11/300 225/18670 0.0011 0.0099 11
GO:0033157 regulation of intracellular protein transport 11/300 225/18670 0.0011 0.0099 11