In the two-group classification, AML samples are basically clustered together no matter rows are scaled are not. Samples can also be separated into three groups where ALL samples are separated into two subgroups.
In the three-group classification, when rows are scaled, only ATC:skmeans
generates stable partition (1-PAC score = 0.96), while when rows are not scaled, no method generates stable partitions, as shown in Table 1 and Figure S11.1.
Rows are scaled | Rows are unscaled | |
---|---|---|
ATC:skmeans | 0.96 | 0.78 |
SD:skmeans | 0.74 | 0.81 |
MAD:skmeans | 0.87 | 0.78 |
CV:skmeans | 0.84 | 0.78 |
ATC:kmeans | 0.55 | 0.77 |
SD:mclust | 0.52 | 0.73 |
CV:mclust | 0.64 | 0.72 |
SD:kmeans | 0.69 | 0.71 |
MAD:mclust | 0.56 | 0.7 |
CV:kmeans | 0.74 | 0.68 |
ATC:pam | 0.53 | 0.65 |
MAD:kmeans | 0.72 | 0.64 |
MAD:pam | 0.45 | 0.56 |
CV:pam | 0.46 | 0.55 |
SD:pam | 0.43 | 0.53 |
MAD:hclust | 0.24 | 0.44 |
ATC:hclust | 0.48 | 0.42 |
SD:hclust | 0.24 | 0.42 |
SD:NMF | 0.58 | 0.41 |
CV:hclust | 0.23 | 0.38 |
MAD:NMF | 0.48 | 0.38 |
CV:NMF | 0.56 | 0.37 |
ATC:NMF | 0.64 | 0.37 |
ATC:mclust | 0.38 | 0.3 |
We pick the three-group classification from ATC:skmeans
for the scaled case because it is the only stable partition, and pick SD:skmeans
for the unscaled case because it has the highest 1-PAC score although it is not a stable partition. Besides the AML/ALL annotation, the original Golub study also provides B-cell/T-cell annotation for the ALL samples. The cola classifications and the annotations are visualized in Figure S11.2.
To make it easier to describe, we term the classification from the scaled matrix as \(C_{s, 3}\) (or C_{s,3} if it cannot be rendered as math symbols) and the classification from the unscaled matrix as \(C_{u,3}\) (or C_{u,3}).
In Figure S11.2, we can observe that both classification \(C_{s, 3}\) and \(C_{u, 3}\) separate ALL samples into two groups, but the classifications are different. \(C_{u,3}\) separates ALL samples into two groups that fit very well with the B-cell/T-cell annotation while \(C_{s, 3}\) gives a new classification. Note in the Golub study, the B-cell/T-cell classification on ALL samples were based on SOM on the unscaled matrix, so it is expected that \(C_{u,3}\) agrees on the B-cell/T-cell classification, also there were no stability accessment on the classification in the original study.
In the PCA plots in Fgiure 3, all three groups are separated very well under \(C_{s, 3}\), while group 2 and group3 can hardly be separated under \(C_{u, 3}\).
Next we look at the significantly expressed genes under the two classifications, illustrated in Figure S11.4. Both classifications give amount of sigature genes, which is mainly due to the difference between ALL and AML. To see how different methods affect the classifiction on ALL samples, we should only look at the ALL samples, as described in the next section.
We remove the samples with class label 1 (which corresponds to AML samples) in both classifications, and we apply t-test between group 2 and group 3 samples. The significant genes under the two classifications are visualized as heatmaps in Figure S11.5.
Since now we only look at the two groups in the two classifications, we modify the symbols of the two classification to \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\).
A direct conclusion from Figure S11.5 is there are far more significant genes under \(C^{(2)}_{s,3}\) (1217 genes) than \(C^{(2)}_{u,3}\) (245 genes).
Since Figure S11.5 only shows the relative expression (the scaled expression), in Figure S11.6, we check the distribution of the absolute expression level of the signature genes in the two classifications, visualized in Figure S11.6. Figure S11.6 shows both signature genes are more enriched in the highly expressed genes, where signatures from \(C^{(2)}_{s,3}\) also cover genes with moderate expression levels.
The two sets of signature genes have very small overlap, illustrated in Figure S11.7.
Similar as the analysis in the two-group classification, we check the biological functions that are enriched in the two sets of signature genes from \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\). Mainly because of the high amount of signature genes from \(C^{(2)}_{s,3}\), it has far more enriched GO functions than \(C^{(2)}_{u,3}\) (Figure S11.8).
As conclusions, it seems the classification from \(C^{(2)}_{s,3}\) is more reasonable because there are many signature genes as well as enriched biolofical functions, which might provide a new and different view to the B-cell/T-cell classification.
ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | Count |
---|---|---|---|---|---|---|
GO:0009725 | response to hormone | 118/979 | 987/18670 | 0e+00 | 0.0000 | 118 |
GO:0010243 | response to organonitrogen compound | 115/979 | 998/18670 | 0e+00 | 0.0000 | 115 |
GO:0044419 | interspecies interaction between organisms | 105/979 | 932/18670 | 0e+00 | 0.0000 | 105 |
GO:1901699 | cellular response to nitrogen compound | 82/979 | 648/18670 | 0e+00 | 0.0000 | 82 |
GO:0019725 | cellular homeostasis | 107/979 | 970/18670 | 0e+00 | 0.0000 | 107 |
GO:0071417 | cellular response to organonitrogen compound | 75/979 | 585/18670 | 0e+00 | 0.0000 | 75 |
GO:0033993 | response to lipid | 101/979 | 923/18670 | 0e+00 | 0.0000 | 101 |
GO:0014070 | response to organic cyclic compound | 100/979 | 915/18670 | 0e+00 | 0.0000 | 100 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 84/979 | 719/18670 | 0e+00 | 0.0000 | 84 |
GO:0051050 | positive regulation of transport | 104/979 | 982/18670 | 0e+00 | 0.0000 | 104 |
GO:0044403 | symbiont process | 96/979 | 884/18670 | 0e+00 | 0.0000 | 96 |
GO:0032870 | cellular response to hormone stimulus | 81/979 | 701/18670 | 0e+00 | 0.0000 | 81 |
GO:0016032 | viral process | 91/979 | 833/18670 | 0e+00 | 0.0000 | 91 |
GO:1901652 | response to peptide | 66/979 | 520/18670 | 0e+00 | 0.0000 | 66 |
GO:0016071 | mRNA metabolic process | 94/979 | 877/18670 | 0e+00 | 0.0000 | 94 |
GO:0055082 | cellular chemical homeostasis | 87/979 | 812/18670 | 0e+00 | 0.0000 | 87 |
GO:0036293 | response to decreased oxygen levels | 51/979 | 370/18670 | 0e+00 | 0.0000 | 51 |
GO:0001666 | response to hypoxia | 50/979 | 359/18670 | 0e+00 | 0.0000 | 50 |
GO:0070482 | response to oxygen levels | 53/979 | 394/18670 | 0e+00 | 0.0000 | 53 |
GO:0019221 | cytokine-mediated signaling pathway | 84/979 | 798/18670 | 0e+00 | 0.0000 | 84 |
GO:0009894 | regulation of catabolic process | 97/979 | 979/18670 | 0e+00 | 0.0000 | 97 |
GO:0008015 | blood circulation | 64/979 | 541/18670 | 0e+00 | 0.0000 | 64 |
GO:1901653 | cellular response to peptide | 51/979 | 385/18670 | 0e+00 | 0.0000 | 51 |
GO:0051046 | regulation of secretion | 84/979 | 811/18670 | 0e+00 | 0.0000 | 84 |
GO:0003013 | circulatory system process | 64/979 | 551/18670 | 0e+00 | 0.0000 | 64 |
GO:1903311 | regulation of mRNA metabolic process | 45/979 | 324/18670 | 0e+00 | 0.0000 | 45 |
GO:0048534 | hematopoietic or lymphoid organ development | 92/979 | 929/18670 | 0e+00 | 0.0000 | 92 |
GO:0002520 | immune system development | 96/979 | 985/18670 | 0e+00 | 0.0000 | 96 |
GO:0048545 | response to steroid hormone | 50/979 | 385/18670 | 0e+00 | 0.0000 | 50 |
GO:0009611 | response to wounding | 73/979 | 678/18670 | 0e+00 | 0.0000 | 73 |
GO:0031329 | regulation of cellular catabolic process | 87/979 | 871/18670 | 0e+00 | 0.0000 | 87 |
GO:0000165 | MAPK cascade | 93/979 | 958/18670 | 0e+00 | 0.0000 | 93 |
GO:0008380 | RNA splicing | 56/979 | 469/18670 | 0e+00 | 0.0000 | 56 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 25/979 | 127/18670 | 0e+00 | 0.0000 | 25 |
GO:0048732 | gland development | 53/979 | 434/18670 | 0e+00 | 0.0000 | 53 |
GO:0030003 | cellular cation homeostasis | 70/979 | 652/18670 | 0e+00 | 0.0000 | 70 |
GO:0023014 | signal transduction by protein phosphorylation | 93/979 | 969/18670 | 0e+00 | 0.0000 | 93 |
GO:0009408 | response to heat | 30/979 | 176/18670 | 0e+00 | 0.0000 | 30 |
GO:0043434 | response to peptide hormone | 53/979 | 436/18670 | 0e+00 | 0.0000 | 53 |
GO:0030097 | hemopoiesis | 87/979 | 887/18670 | 0e+00 | 0.0000 | 87 |
GO:0009266 | response to temperature stimulus | 36/979 | 243/18670 | 0e+00 | 0.0000 | 36 |
GO:0055080 | cation homeostasis | 75/979 | 730/18670 | 0e+00 | 0.0000 | 75 |
GO:0051169 | nuclear transport | 45/979 | 346/18670 | 0e+00 | 0.0000 | 45 |
GO:0006873 | cellular ion homeostasis | 70/979 | 665/18670 | 0e+00 | 0.0000 | 70 |
GO:0033238 | regulation of cellular amine metabolic process | 19/979 | 81/18670 | 0e+00 | 0.0000 | 19 |
GO:0060341 | regulation of cellular localization | 87/979 | 906/18670 | 0e+00 | 0.0000 | 87 |
GO:1903530 | regulation of secretion by cell | 76/979 | 753/18670 | 0e+00 | 0.0000 | 76 |
GO:0098771 | inorganic ion homeostasis | 75/979 | 741/18670 | 0e+00 | 0.0000 | 75 |
GO:0048511 | rhythmic process | 40/979 | 295/18670 | 0e+00 | 0.0000 | 40 |
GO:0090087 | regulation of peptide transport | 74/979 | 729/18670 | 0e+00 | 0.0000 | 74 |
GO:0006913 | nucleocytoplasmic transport | 44/979 | 343/18670 | 0e+00 | 0.0000 | 44 |
GO:0071396 | cellular response to lipid | 65/979 | 610/18670 | 0e+00 | 0.0000 | 65 |
GO:0000375 | RNA splicing, via transesterification reactions | 47/979 | 382/18670 | 0e+00 | 0.0000 | 47 |
GO:0060322 | head development | 77/979 | 776/18670 | 0e+00 | 0.0000 | 77 |
GO:0046883 | regulation of hormone secretion | 37/979 | 266/18670 | 0e+00 | 0.0000 | 37 |
GO:0044706 | multi-multicellular organism process | 33/979 | 222/18670 | 0e+00 | 0.0000 | 33 |
GO:0033365 | protein localization to organelle | 87/979 | 922/18670 | 0e+00 | 0.0000 | 87 |
GO:0002444 | myeloid leukocyte mediated immunity | 60/979 | 551/18670 | 0e+00 | 0.0000 | 60 |
GO:0009636 | response to toxic substance | 58/979 | 525/18670 | 0e+00 | 0.0000 | 58 |
GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 23/979 | 121/18670 | 0e+00 | 0.0000 | 23 |
GO:0023061 | signal release | 53/979 | 462/18670 | 0e+00 | 0.0000 | 53 |
GO:0006875 | cellular metal ion homeostasis | 62/979 | 579/18670 | 0e+00 | 0.0000 | 62 |
GO:0050852 | T cell receptor signaling pathway | 31/979 | 202/18670 | 0e+00 | 0.0000 | 31 |
GO:0002283 | neutrophil activation involved in immune response | 55/979 | 488/18670 | 0e+00 | 0.0000 | 55 |
GO:0006974 | cellular response to DNA damage stimulus | 82/979 | 854/18670 | 0e+00 | 0.0000 | 82 |
GO:0006397 | mRNA processing | 59/979 | 541/18670 | 0e+00 | 0.0000 | 59 |
GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 46/979 | 379/18670 | 0e+00 | 0.0000 | 46 |
GO:0000398 | mRNA splicing, via spliceosome | 46/979 | 379/18670 | 0e+00 | 0.0000 | 46 |
GO:0043069 | negative regulation of programmed cell death | 87/979 | 932/18670 | 0e+00 | 0.0000 | 87 |
GO:0055065 | metal ion homeostasis | 67/979 | 653/18670 | 0e+00 | 0.0000 | 67 |
GO:0007409 | axonogenesis | 53/979 | 468/18670 | 0e+00 | 0.0000 | 53 |
GO:0030072 | peptide hormone secretion | 35/979 | 250/18670 | 0e+00 | 0.0000 | 35 |
GO:0035821 | modification of morphology or physiology of other organism | 27/979 | 164/18670 | 0e+00 | 0.0000 | 27 |
GO:0034976 | response to endoplasmic reticulum stress | 38/979 | 285/18670 | 0e+00 | 0.0000 | 38 |
GO:0071375 | cellular response to peptide hormone stimulus | 41/979 | 321/18670 | 0e+00 | 0.0000 | 41 |
GO:0008284 | positive regulation of cell proliferation | 88/979 | 951/18670 | 0e+00 | 0.0000 | 88 |
GO:0017144 | drug metabolic process | 81/979 | 851/18670 | 0e+00 | 0.0000 | 81 |
GO:0043408 | regulation of MAPK cascade | 75/979 | 768/18670 | 0e+00 | 0.0000 | 75 |
GO:0090276 | regulation of peptide hormone secretion | 31/979 | 208/18670 | 0e+00 | 0.0000 | 31 |
GO:0043312 | neutrophil degranulation | 54/979 | 485/18670 | 0e+00 | 0.0000 | 54 |
GO:0042119 | neutrophil activation | 55/979 | 498/18670 | 0e+00 | 0.0000 | 55 |
GO:0050801 | ion homeostasis | 78/979 | 811/18670 | 0e+00 | 0.0000 | 78 |
GO:2000027 | regulation of animal organ morphogenesis | 35/979 | 253/18670 | 0e+00 | 0.0000 | 35 |
GO:0043066 | negative regulation of apoptotic process | 85/979 | 911/18670 | 0e+00 | 0.0000 | 85 |
GO:0002446 | neutrophil mediated immunity | 55/979 | 499/18670 | 0e+00 | 0.0000 | 55 |
GO:0043488 | regulation of mRNA stability | 28/979 | 177/18670 | 0e+00 | 0.0000 | 28 |
GO:0046879 | hormone secretion | 40/979 | 312/18670 | 0e+00 | 0.0000 | 40 |
GO:0051098 | regulation of binding | 45/979 | 373/18670 | 0e+00 | 0.0000 | 45 |
GO:0061564 | axon development | 56/979 | 514/18670 | 0e+00 | 0.0000 | 56 |
GO:0050878 | regulation of body fluid levels | 55/979 | 501/18670 | 0e+00 | 0.0000 | 55 |
GO:0071407 | cellular response to organic cyclic compound | 58/979 | 542/18670 | 0e+00 | 0.0000 | 58 |
GO:0007420 | brain development | 72/979 | 733/18670 | 0e+00 | 0.0000 | 72 |
GO:0006887 | exocytosis | 84/979 | 903/18670 | 0e+00 | 0.0000 | 84 |
GO:0036230 | granulocyte activation | 55/979 | 504/18670 | 0e+00 | 0.0000 | 55 |
GO:1905330 | regulation of morphogenesis of an epithelium | 28/979 | 180/18670 | 0e+00 | 0.0000 | 28 |
GO:0033674 | positive regulation of kinase activity | 60/979 | 573/18670 | 0e+00 | 0.0000 | 60 |
GO:0007565 | female pregnancy | 29/979 | 192/18670 | 0e+00 | 0.0000 | 29 |
GO:0001101 | response to acid chemical | 42/979 | 343/18670 | 0e+00 | 0.0000 | 42 |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 19/979 | 93/18670 | 0e+00 | 0.0000 | 19 |
GO:0019884 | antigen processing and presentation of exogenous antigen | 28/979 | 182/18670 | 0e+00 | 0.0000 | 28 |
GO:0006352 | DNA-templated transcription, initiation | 34/979 | 249/18670 | 0e+00 | 0.0000 | 34 |
GO:0043487 | regulation of RNA stability | 28/979 | 183/18670 | 0e+00 | 0.0000 | 28 |
GO:0043549 | regulation of kinase activity | 81/979 | 870/18670 | 0e+00 | 0.0000 | 81 |
GO:0006457 | protein folding | 32/979 | 227/18670 | 0e+00 | 0.0000 | 32 |
GO:0098657 | import into cell | 86/979 | 945/18670 | 0e+00 | 0.0000 | 86 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 17/979 | 77/18670 | 0e+00 | 0.0000 | 17 |
GO:0009914 | hormone transport | 40/979 | 322/18670 | 0e+00 | 0.0000 | 40 |
GO:1901361 | organic cyclic compound catabolic process | 72/979 | 745/18670 | 0e+00 | 0.0000 | 72 |
GO:0034655 | nucleobase-containing compound catabolic process | 65/979 | 648/18670 | 0e+00 | 0.0000 | 65 |
GO:0070201 | regulation of establishment of protein localization | 72/979 | 746/18670 | 0e+00 | 0.0000 | 72 |
GO:0045597 | positive regulation of cell differentiation | 89/979 | 991/18670 | 0e+00 | 0.0000 | 89 |
GO:0034612 | response to tumor necrosis factor | 39/979 | 312/18670 | 0e+00 | 0.0000 | 39 |
GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 27/979 | 175/18670 | 0e+00 | 0.0000 | 27 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 19/979 | 96/18670 | 0e+00 | 0.0000 | 19 |
GO:0002275 | myeloid cell activation involved in immune response | 57/979 | 544/18670 | 0e+00 | 0.0000 | 57 |
GO:0009991 | response to extracellular stimulus | 56/979 | 531/18670 | 0e+00 | 0.0000 | 56 |
GO:0046700 | heterocycle catabolic process | 68/979 | 695/18670 | 0e+00 | 0.0000 | 68 |
GO:0072503 | cellular divalent inorganic cation homeostasis | 53/979 | 493/18670 | 0e+00 | 0.0000 | 53 |
GO:0071356 | cellular response to tumor necrosis factor | 37/979 | 291/18670 | 0e+00 | 0.0000 | 37 |
GO:0048729 | tissue morphogenesis | 66/979 | 670/18670 | 0e+00 | 0.0000 | 66 |
GO:0043299 | leukocyte degranulation | 56/979 | 534/18670 | 0e+00 | 0.0000 | 56 |
GO:0030522 | intracellular receptor signaling pathway | 36/979 | 280/18670 | 0e+00 | 0.0000 | 36 |
GO:0097190 | apoptotic signaling pathway | 61/979 | 602/18670 | 0e+00 | 0.0000 | 61 |
GO:0048002 | antigen processing and presentation of peptide antigen | 28/979 | 189/18670 | 0e+00 | 0.0000 | 28 |
GO:0071453 | cellular response to oxygen levels | 32/979 | 234/18670 | 0e+00 | 0.0000 | 32 |
GO:0006836 | neurotransmitter transport | 35/979 | 269/18670 | 0e+00 | 0.0000 | 35 |
GO:0009755 | hormone-mediated signaling pathway | 32/979 | 235/18670 | 0e+00 | 0.0000 | 32 |
GO:0009308 | amine metabolic process | 23/979 | 138/18670 | 0e+00 | 0.0000 | 23 |
GO:0031667 | response to nutrient levels | 53/979 | 499/18670 | 0e+00 | 0.0000 | 53 |
GO:0051347 | positive regulation of transferase activity | 64/979 | 649/18670 | 0e+00 | 0.0000 | 64 |
GO:0072507 | divalent inorganic cation homeostasis | 54/979 | 513/18670 | 0e+00 | 0.0000 | 54 |
GO:0032868 | response to insulin | 35/979 | 272/18670 | 0e+00 | 0.0000 | 35 |
GO:0006954 | inflammatory response | 78/979 | 848/18670 | 0e+00 | 0.0000 | 78 |
GO:0044106 | cellular amine metabolic process | 22/979 | 129/18670 | 0e+00 | 0.0000 | 22 |
GO:0007568 | aging | 39/979 | 321/18670 | 0e+00 | 0.0000 | 39 |
GO:0019882 | antigen processing and presentation | 31/979 | 226/18670 | 0e+00 | 0.0000 | 31 |
GO:0035567 | non-canonical Wnt signaling pathway | 24/979 | 150/18670 | 0e+00 | 0.0000 | 24 |
GO:0002790 | peptide secretion | 62/979 | 624/18670 | 0e+00 | 0.0000 | 62 |
GO:0071383 | cellular response to steroid hormone stimulus | 33/979 | 250/18670 | 0e+00 | 0.0000 | 33 |
GO:0034504 | protein localization to nucleus | 34/979 | 262/18670 | 0e+00 | 0.0000 | 34 |
GO:0032869 | cellular response to insulin stimulus | 30/979 | 216/18670 | 0e+00 | 0.0000 | 30 |
GO:0044270 | cellular nitrogen compound catabolic process | 67/979 | 696/18670 | 0e+00 | 0.0000 | 67 |
GO:0001819 | positive regulation of cytokine production | 50/979 | 464/18670 | 0e+00 | 0.0000 | 50 |
GO:0036294 | cellular response to decreased oxygen levels | 30/979 | 217/18670 | 0e+00 | 0.0000 | 30 |
GO:0032101 | regulation of response to external stimulus | 82/979 | 913/18670 | 0e+00 | 0.0000 | 82 |
GO:0019439 | aromatic compound catabolic process | 68/979 | 712/18670 | 0e+00 | 0.0000 | 68 |
GO:0042593 | glucose homeostasis | 32/979 | 241/18670 | 0e+00 | 0.0001 | 32 |
GO:0051170 | import into nucleus | 25/979 | 163/18670 | 0e+00 | 0.0001 | 25 |
GO:0070555 | response to interleukin-1 | 29/979 | 207/18670 | 0e+00 | 0.0001 | 29 |
GO:0071456 | cellular response to hypoxia | 29/979 | 207/18670 | 0e+00 | 0.0001 | 29 |
GO:0051047 | positive regulation of secretion | 47/979 | 428/18670 | 0e+00 | 0.0001 | 47 |
GO:0033500 | carbohydrate homeostasis | 32/979 | 242/18670 | 0e+00 | 0.0001 | 32 |
GO:0050778 | positive regulation of immune response | 81/979 | 902/18670 | 0e+00 | 0.0001 | 81 |
GO:0031175 | neuron projection development | 86/979 | 978/18670 | 0e+00 | 0.0001 | 86 |
GO:0080135 | regulation of cellular response to stress | 70/979 | 746/18670 | 0e+00 | 0.0001 | 70 |
GO:0048608 | reproductive structure development | 47/979 | 431/18670 | 0e+00 | 0.0001 | 47 |
GO:0003006 | developmental process involved in reproduction | 65/979 | 676/18670 | 0e+00 | 0.0001 | 65 |
GO:0061013 | regulation of mRNA catabolic process | 28/979 | 199/18670 | 0e+00 | 0.0001 | 28 |
GO:0010720 | positive regulation of cell development | 56/979 | 553/18670 | 0e+00 | 0.0001 | 56 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 27/979 | 188/18670 | 0e+00 | 0.0001 | 27 |
GO:0040008 | regulation of growth | 65/979 | 679/18670 | 0e+00 | 0.0001 | 65 |
GO:0002274 | myeloid leukocyte activation | 63/979 | 651/18670 | 0e+00 | 0.0001 | 63 |
GO:1902750 | negative regulation of cell cycle G2/M phase transition | 19/979 | 105/18670 | 0e+00 | 0.0001 | 19 |
GO:0045055 | regulated exocytosis | 73/979 | 794/18670 | 0e+00 | 0.0001 | 73 |
GO:0061458 | reproductive system development | 47/979 | 434/18670 | 0e+00 | 0.0001 | 47 |
GO:0048667 | cell morphogenesis involved in neuron differentiation | 58/979 | 583/18670 | 0e+00 | 0.0001 | 58 |
GO:1903706 | regulation of hemopoiesis | 50/979 | 475/18670 | 0e+00 | 0.0001 | 50 |
GO:0009895 | negative regulation of catabolic process | 37/979 | 308/18670 | 0e+00 | 0.0001 | 37 |
GO:0006401 | RNA catabolic process | 44/979 | 397/18670 | 0e+00 | 0.0001 | 44 |
GO:0071347 | cellular response to interleukin-1 | 26/979 | 179/18670 | 0e+00 | 0.0001 | 26 |
GO:0044057 | regulation of system process | 60/979 | 613/18670 | 0e+00 | 0.0001 | 60 |
GO:0034605 | cellular response to heat | 22/979 | 137/18670 | 0e+00 | 0.0001 | 22 |
GO:0051100 | negative regulation of binding | 25/979 | 169/18670 | 0e+00 | 0.0001 | 25 |
GO:0051223 | regulation of protein transport | 66/979 | 699/18670 | 0e+00 | 0.0001 | 66 |
GO:0045860 | positive regulation of protein kinase activity | 54/979 | 532/18670 | 0e+00 | 0.0001 | 54 |
GO:0043410 | positive regulation of MAPK cascade | 55/979 | 546/18670 | 0e+00 | 0.0001 | 55 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 16/979 | 79/18670 | 0e+00 | 0.0001 | 16 |
GO:0019932 | second-messenger-mediated signaling | 47/979 | 439/18670 | 0e+00 | 0.0001 | 47 |
GO:0000904 | cell morphogenesis involved in differentiation | 69/979 | 744/18670 | 0e+00 | 0.0001 | 69 |
GO:0006521 | regulation of cellular amino acid metabolic process | 14/979 | 62/18670 | 0e+00 | 0.0001 | 14 |
GO:0001504 | neurotransmitter uptake | 12/979 | 46/18670 | 0e+00 | 0.0001 | 12 |
GO:0008285 | negative regulation of cell proliferation | 70/979 | 760/18670 | 0e+00 | 0.0001 | 70 |
GO:0099536 | synaptic signaling | 67/979 | 717/18670 | 0e+00 | 0.0001 | 67 |
GO:0008217 | regulation of blood pressure | 26/979 | 182/18670 | 0e+00 | 0.0001 | 26 |
GO:0001816 | cytokine production | 72/979 | 790/18670 | 0e+00 | 0.0001 | 72 |
GO:0001944 | vasculature development | 72/979 | 792/18670 | 0e+00 | 0.0001 | 72 |
GO:0045859 | regulation of protein kinase activity | 72/979 | 792/18670 | 0e+00 | 0.0001 | 72 |
GO:0055074 | calcium ion homeostasis | 49/979 | 471/18670 | 0e+00 | 0.0001 | 49 |
GO:1902036 | regulation of hematopoietic stem cell differentiation | 15/979 | 72/18670 | 0e+00 | 0.0001 | 15 |
GO:0031145 | anaphase-promoting complex-dependent catabolic process | 16/979 | 81/18670 | 0e+00 | 0.0001 | 16 |
GO:0006874 | cellular calcium ion homeostasis | 48/979 | 458/18670 | 0e+00 | 0.0001 | 48 |
GO:0019373 | epoxygenase P450 pathway | 8/979 | 20/18670 | 0e+00 | 0.0001 | 8 |
GO:0030073 | insulin secretion | 28/979 | 207/18670 | 0e+00 | 0.0001 | 28 |
GO:0051338 | regulation of transferase activity | 84/979 | 972/18670 | 0e+00 | 0.0001 | 84 |
GO:0051090 | regulation of DNA-binding transcription factor activity | 46/979 | 432/18670 | 0e+00 | 0.0001 | 46 |
GO:0001505 | regulation of neurotransmitter levels | 40/979 | 354/18670 | 0e+00 | 0.0001 | 40 |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 27/979 | 196/18670 | 0e+00 | 0.0001 | 27 |
GO:0002791 | regulation of peptide secretion | 51/979 | 500/18670 | 0e+00 | 0.0001 | 51 |
GO:0050769 | positive regulation of neurogenesis | 49/979 | 474/18670 | 0e+00 | 0.0001 | 49 |
GO:0010817 | regulation of hormone levels | 53/979 | 529/18670 | 0e+00 | 0.0001 | 53 |
GO:0072358 | cardiovascular system development | 72/979 | 801/18670 | 0e+00 | 0.0002 | 72 |
GO:0032386 | regulation of intracellular transport | 45/979 | 423/18670 | 0e+00 | 0.0002 | 45 |
GO:0060218 | hematopoietic stem cell differentiation | 16/979 | 83/18670 | 0e+00 | 0.0002 | 16 |
GO:0001525 | angiogenesis | 57/979 | 587/18670 | 0e+00 | 0.0002 | 57 |
GO:0035239 | tube morphogenesis | 80/979 | 920/18670 | 0e+00 | 0.0002 | 80 |
GO:0098810 | neurotransmitter reuptake | 9/979 | 27/18670 | 0e+00 | 0.0002 | 9 |
GO:0043902 | positive regulation of multi-organism process | 26/979 | 188/18670 | 0e+00 | 0.0002 | 26 |
GO:1903532 | positive regulation of secretion by cell | 43/979 | 399/18670 | 0e+00 | 0.0002 | 43 |
GO:0006936 | muscle contraction | 40/979 | 360/18670 | 0e+00 | 0.0002 | 40 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 15/979 | 75/18670 | 0e+00 | 0.0002 | 15 |
GO:0072594 | establishment of protein localization to organelle | 54/979 | 549/18670 | 0e+00 | 0.0002 | 54 |
GO:0001817 | regulation of cytokine production | 66/979 | 719/18670 | 0e+00 | 0.0002 | 66 |
GO:0010948 | negative regulation of cell cycle process | 40/979 | 361/18670 | 0e+00 | 0.0002 | 40 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 24/979 | 167/18670 | 0e+00 | 0.0002 | 24 |
GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 16/979 | 85/18670 | 0e+00 | 0.0002 | 16 |
GO:0045471 | response to ethanol | 20/979 | 125/18670 | 0e+00 | 0.0002 | 20 |
GO:0022407 | regulation of cell-cell adhesion | 43/979 | 403/18670 | 0e+00 | 0.0002 | 43 |
GO:0043270 | positive regulation of ion transport | 33/979 | 275/18670 | 0e+00 | 0.0002 | 33 |
GO:0032735 | positive regulation of interleukin-12 production | 10/979 | 35/18670 | 0e+00 | 0.0002 | 10 |
GO:0002253 | activation of immune response | 66/979 | 724/18670 | 0e+00 | 0.0002 | 66 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 24/979 | 169/18670 | 0e+00 | 0.0002 | 24 |
GO:0048514 | blood vessel morphogenesis | 63/979 | 681/18670 | 0e+00 | 0.0002 | 63 |
GO:0006091 | generation of precursor metabolites and energy | 52/979 | 526/18670 | 0e+00 | 0.0002 | 52 |
GO:0009615 | response to virus | 37/979 | 326/18670 | 0e+00 | 0.0002 | 37 |
GO:0048013 | ephrin receptor signaling pathway | 16/979 | 86/18670 | 0e+00 | 0.0002 | 16 |
GO:0002443 | leukocyte mediated immunity | 76/979 | 874/18670 | 0e+00 | 0.0003 | 76 |
GO:0045786 | negative regulation of cell cycle | 60/979 | 641/18670 | 0e+00 | 0.0003 | 60 |
GO:0043269 | regulation of ion transport | 64/979 | 699/18670 | 0e+00 | 0.0003 | 64 |
GO:0043393 | regulation of protein binding | 28/979 | 217/18670 | 0e+00 | 0.0003 | 28 |
GO:0009060 | aerobic respiration | 16/979 | 87/18670 | 0e+00 | 0.0003 | 16 |
GO:0048524 | positive regulation of viral process | 18/979 | 107/18670 | 0e+00 | 0.0003 | 18 |
GO:0046794 | transport of virus | 13/979 | 60/18670 | 0e+00 | 0.0003 | 13 |
GO:0006403 | RNA localization | 29/979 | 230/18670 | 0e+00 | 0.0003 | 29 |
GO:0009743 | response to carbohydrate | 29/979 | 230/18670 | 0e+00 | 0.0003 | 29 |
GO:0001568 | blood vessel development | 68/979 | 761/18670 | 0e+00 | 0.0003 | 68 |
GO:0007268 | chemical synaptic transmission | 64/979 | 703/18670 | 0e+00 | 0.0003 | 64 |
GO:0098916 | anterograde trans-synaptic signaling | 64/979 | 703/18670 | 0e+00 | 0.0003 | 64 |
GO:0040007 | growth | 83/979 | 986/18670 | 0e+00 | 0.0003 | 83 |
GO:0048863 | stem cell differentiation | 31/979 | 257/18670 | 0e+00 | 0.0003 | 31 |
GO:0097305 | response to alcohol | 29/979 | 233/18670 | 0e+00 | 0.0003 | 29 |
GO:0007548 | sex differentiation | 32/979 | 270/18670 | 0e+00 | 0.0004 | 32 |
GO:0016579 | protein deubiquitination | 33/979 | 283/18670 | 0e+00 | 0.0004 | 33 |
GO:0002009 | morphogenesis of an epithelium | 52/979 | 537/18670 | 0e+00 | 0.0004 | 52 |
GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 58/979 | 622/18670 | 0e+00 | 0.0004 | 58 |
GO:0031347 | regulation of defense response | 77/979 | 901/18670 | 0e+00 | 0.0004 | 77 |
GO:0046887 | positive regulation of hormone secretion | 20/979 | 131/18670 | 0e+00 | 0.0004 | 20 |
GO:0006281 | DNA repair | 53/979 | 552/18670 | 0e+00 | 0.0004 | 53 |
GO:0000086 | G2/M transition of mitotic cell cycle | 30/979 | 247/18670 | 0e+00 | 0.0004 | 30 |
GO:0050796 | regulation of insulin secretion | 24/979 | 176/18670 | 0e+00 | 0.0004 | 24 |
GO:0099537 | trans-synaptic signaling | 64/979 | 711/18670 | 0e+00 | 0.0004 | 64 |
GO:0006606 | protein import into nucleus | 21/979 | 143/18670 | 0e+00 | 0.0004 | 21 |
GO:0018105 | peptidyl-serine phosphorylation | 34/979 | 299/18670 | 0e+00 | 0.0004 | 34 |
GO:0070646 | protein modification by small protein removal | 34/979 | 299/18670 | 0e+00 | 0.0004 | 34 |
GO:0006402 | mRNA catabolic process | 39/979 | 364/18670 | 0e+00 | 0.0004 | 39 |
GO:1902749 | regulation of cell cycle G2/M phase transition | 27/979 | 213/18670 | 0e+00 | 0.0005 | 27 |
GO:0062012 | regulation of small molecule metabolic process | 46/979 | 459/18670 | 0e+00 | 0.0005 | 46 |
GO:0051817 | modification of morphology or physiology of other organism involved in symbiotic interaction | 18/979 | 112/18670 | 0e+00 | 0.0005 | 18 |
GO:0015672 | monovalent inorganic cation transport | 51/979 | 529/18670 | 0e+00 | 0.0005 | 51 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 43/979 | 419/18670 | 0e+00 | 0.0005 | 43 |
GO:0043065 | positive regulation of apoptotic process | 61/979 | 672/18670 | 0e+00 | 0.0005 | 61 |
GO:0006935 | chemotaxis | 59/979 | 644/18670 | 0e+00 | 0.0005 | 59 |
GO:0046677 | response to antibiotic | 36/979 | 327/18670 | 0e+00 | 0.0005 | 36 |
GO:0044766 | multi-organism transport | 14/979 | 73/18670 | 0e+00 | 0.0005 | 14 |
GO:1902579 | multi-organism localization | 14/979 | 73/18670 | 0e+00 | 0.0005 | 14 |
GO:0044772 | mitotic cell cycle phase transition | 55/979 | 588/18670 | 0e+00 | 0.0005 | 55 |
GO:0031330 | negative regulation of cellular catabolic process | 31/979 | 264/18670 | 0e+00 | 0.0005 | 31 |
GO:0050767 | regulation of neurogenesis | 71/979 | 822/18670 | 0e+00 | 0.0005 | 71 |
GO:0042330 | taxis | 59/979 | 646/18670 | 0e+00 | 0.0005 | 59 |
GO:0002764 | immune response-regulating signaling pathway | 61/979 | 675/18670 | 0e+00 | 0.0005 | 61 |
GO:0060627 | regulation of vesicle-mediated transport | 51/979 | 532/18670 | 0e+00 | 0.0005 | 51 |
GO:0030001 | metal ion transport | 75/979 | 883/18670 | 0e+00 | 0.0005 | 75 |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 60/979 | 662/18670 | 0e+00 | 0.0006 | 60 |
GO:0048812 | neuron projection morphogenesis | 59/979 | 648/18670 | 0e+00 | 0.0006 | 59 |
GO:0032615 | interleukin-12 production | 12/979 | 56/18670 | 0e+00 | 0.0006 | 12 |
GO:0009306 | protein secretion | 55/979 | 591/18670 | 0e+00 | 0.0006 | 55 |
GO:0038093 | Fc receptor signaling pathway | 29/979 | 241/18670 | 0e+00 | 0.0006 | 29 |
GO:0002366 | leukocyte activation involved in immune response | 63/979 | 707/18670 | 0e+00 | 0.0006 | 63 |
GO:0003012 | muscle system process | 46/979 | 465/18670 | 0e+00 | 0.0006 | 46 |
GO:0045333 | cellular respiration | 25/979 | 193/18670 | 0e+00 | 0.0006 | 25 |
GO:0045088 | regulation of innate immune response | 45/979 | 452/18670 | 0e+00 | 0.0006 | 45 |
GO:0043068 | positive regulation of programmed cell death | 61/979 | 680/18670 | 0e+00 | 0.0006 | 61 |
GO:0048858 | cell projection morphogenesis | 60/979 | 666/18670 | 0e+00 | 0.0006 | 60 |
GO:0050684 | regulation of mRNA processing | 20/979 | 137/18670 | 0e+00 | 0.0006 | 20 |
GO:0006937 | regulation of muscle contraction | 23/979 | 171/18670 | 0e+00 | 0.0007 | 23 |
GO:0002263 | cell activation involved in immune response | 63/979 | 711/18670 | 0e+00 | 0.0007 | 63 |
GO:0030100 | regulation of endocytosis | 32/979 | 281/18670 | 0e+00 | 0.0007 | 32 |
GO:0075733 | intracellular transport of virus | 12/979 | 57/18670 | 0e+00 | 0.0007 | 12 |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 30/979 | 256/18670 | 0e+00 | 0.0007 | 30 |
GO:0034284 | response to monosaccharide | 26/979 | 207/18670 | 0e+00 | 0.0007 | 26 |
GO:2000736 | regulation of stem cell differentiation | 18/979 | 116/18670 | 0e+00 | 0.0007 | 18 |
GO:0006470 | protein dephosphorylation | 35/979 | 321/18670 | 0e+00 | 0.0007 | 35 |
GO:0043401 | steroid hormone mediated signaling pathway | 24/979 | 184/18670 | 0e+00 | 0.0007 | 24 |
GO:0002757 | immune response-activating signal transduction | 58/979 | 641/18670 | 0e+00 | 0.0007 | 58 |
GO:0032990 | cell part morphogenesis | 61/979 | 685/18670 | 0e+00 | 0.0007 | 61 |
GO:0018209 | peptidyl-serine modification | 35/979 | 322/18670 | 0e+00 | 0.0007 | 35 |
GO:0030099 | myeloid cell differentiation | 42/979 | 416/18670 | 0e+00 | 0.0008 | 42 |
GO:0010942 | positive regulation of cell death | 64/979 | 730/18670 | 0e+00 | 0.0008 | 64 |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 27/979 | 221/18670 | 0e+00 | 0.0008 | 27 |
GO:1901990 | regulation of mitotic cell cycle phase transition | 44/979 | 444/18670 | 0e+00 | 0.0008 | 44 |
GO:0071900 | regulation of protein serine/threonine kinase activity | 49/979 | 515/18670 | 0e+00 | 0.0008 | 49 |
GO:0015980 | energy derivation by oxidation of organic compounds | 32/979 | 285/18670 | 0e+00 | 0.0008 | 32 |
GO:1902600 | proton transmembrane transport | 22/979 | 163/18670 | 0e+00 | 0.0009 | 22 |
GO:0043900 | regulation of multi-organism process | 41/979 | 405/18670 | 0e+00 | 0.0009 | 41 |
GO:0044770 | cell cycle phase transition | 57/979 | 631/18670 | 0e+00 | 0.0009 | 57 |
GO:0015696 | ammonium transport | 17/979 | 108/18670 | 0e+00 | 0.0009 | 17 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 17/979 | 108/18670 | 0e+00 | 0.0009 | 17 |
GO:0000122 | negative regulation of transcription by RNA polymerase II | 71/979 | 839/18670 | 0e+00 | 0.0009 | 71 |
GO:0001678 | cellular glucose homeostasis | 21/979 | 152/18670 | 0e+00 | 0.0009 | 21 |
GO:2001233 | regulation of apoptotic signaling pathway | 41/979 | 406/18670 | 0e+00 | 0.0009 | 41 |
GO:0051091 | positive regulation of DNA-binding transcription factor activity | 30/979 | 261/18670 | 0e+00 | 0.0009 | 30 |
GO:0030163 | protein catabolic process | 77/979 | 931/18670 | 0e+00 | 0.0009 | 77 |
GO:0008286 | insulin receptor signaling pathway | 20/979 | 141/18670 | 0e+00 | 0.0009 | 20 |
GO:0030155 | regulation of cell adhesion | 61/979 | 691/18670 | 0e+00 | 0.0009 | 61 |
GO:0048024 | regulation of mRNA splicing, via spliceosome | 16/979 | 98/18670 | 0e+00 | 0.0009 | 16 |
GO:0071363 | cellular response to growth factor stimulus | 62/979 | 706/18670 | 0e+00 | 0.0009 | 62 |
GO:0006520 | cellular amino acid metabolic process | 38/979 | 366/18670 | 0e+00 | 0.0009 | 38 |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 33/979 | 300/18670 | 0e+00 | 0.0009 | 33 |
GO:0010498 | proteasomal protein catabolic process | 46/979 | 477/18670 | 1e-04 | 0.0010 | 46 |
GO:1903047 | mitotic cell cycle process | 73/979 | 873/18670 | 1e-04 | 0.0010 | 73 |
GO:0042110 | T cell activation | 45/979 | 464/18670 | 1e-04 | 0.0010 | 45 |
GO:0090175 | regulation of establishment of planar polarity | 17/979 | 110/18670 | 1e-04 | 0.0011 | 17 |
GO:0035690 | cellular response to drug | 38/979 | 369/18670 | 1e-04 | 0.0011 | 38 |
GO:0051954 | positive regulation of amine transport | 9/979 | 35/18670 | 1e-04 | 0.0011 | 9 |
GO:0060284 | regulation of cell development | 78/979 | 953/18670 | 1e-04 | 0.0011 | 78 |
GO:0007610 | behavior | 54/979 | 594/18670 | 1e-04 | 0.0011 | 54 |
GO:0070371 | ERK1 and ERK2 cascade | 34/979 | 317/18670 | 1e-04 | 0.0011 | 34 |
GO:0043254 | regulation of protein complex assembly | 45/979 | 467/18670 | 1e-04 | 0.0011 | 45 |
GO:0045666 | positive regulation of neuron differentiation | 38/979 | 371/18670 | 1e-04 | 0.0012 | 38 |
GO:0044839 | cell cycle G2/M phase transition | 30/979 | 266/18670 | 1e-04 | 0.0012 | 30 |
GO:0045664 | regulation of neuron differentiation | 58/979 | 656/18670 | 1e-04 | 0.0012 | 58 |
GO:0002573 | myeloid leukocyte differentiation | 25/979 | 204/18670 | 1e-04 | 0.0013 | 25 |
GO:0051962 | positive regulation of nervous system development | 50/979 | 541/18670 | 1e-04 | 0.0013 | 50 |
GO:0032147 | activation of protein kinase activity | 35/979 | 333/18670 | 1e-04 | 0.0013 | 35 |
GO:0051272 | positive regulation of cellular component movement | 53/979 | 585/18670 | 1e-04 | 0.0013 | 53 |
GO:0015837 | amine transport | 16/979 | 102/18670 | 1e-04 | 0.0014 | 16 |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 26/979 | 218/18670 | 1e-04 | 0.0014 | 26 |
GO:0001889 | liver development | 19/979 | 135/18670 | 1e-04 | 0.0014 | 19 |
GO:0043484 | regulation of RNA splicing | 19/979 | 135/18670 | 1e-04 | 0.0014 | 19 |
GO:0001736 | establishment of planar polarity | 18/979 | 124/18670 | 1e-04 | 0.0014 | 18 |
GO:0007164 | establishment of tissue polarity | 18/979 | 124/18670 | 1e-04 | 0.0014 | 18 |
GO:0051101 | regulation of DNA binding | 18/979 | 124/18670 | 1e-04 | 0.0014 | 18 |
GO:0002521 | leukocyte differentiation | 48/979 | 515/18670 | 1e-04 | 0.0014 | 48 |
GO:0019226 | transmission of nerve impulse | 13/979 | 72/18670 | 1e-04 | 0.0014 | 13 |
GO:0007584 | response to nutrient | 26/979 | 219/18670 | 1e-04 | 0.0015 | 26 |
GO:0002064 | epithelial cell development | 25/979 | 207/18670 | 1e-04 | 0.0015 | 25 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 37/979 | 363/18670 | 1e-04 | 0.0015 | 37 |
GO:0032655 | regulation of interleukin-12 production | 11/979 | 54/18670 | 1e-04 | 0.0016 | 11 |
GO:0043405 | regulation of MAP kinase activity | 35/979 | 337/18670 | 1e-04 | 0.0016 | 35 |
GO:0007623 | circadian rhythm | 25/979 | 208/18670 | 1e-04 | 0.0016 | 25 |
GO:0042098 | T cell proliferation | 23/979 | 184/18670 | 1e-04 | 0.0017 | 23 |
GO:0002758 | innate immune response-activating signal transduction | 32/979 | 298/18670 | 1e-04 | 0.0017 | 32 |
GO:0046822 | regulation of nucleocytoplasmic transport | 16/979 | 104/18670 | 1e-04 | 0.0017 | 16 |
GO:0090257 | regulation of muscle system process | 29/979 | 259/18670 | 1e-04 | 0.0017 | 29 |
GO:0018212 | peptidyl-tyrosine modification | 37/979 | 366/18670 | 1e-04 | 0.0018 | 37 |
GO:1903708 | positive regulation of hemopoiesis | 23/979 | 185/18670 | 1e-04 | 0.0018 | 23 |
GO:0061008 | hepaticobiliary system development | 19/979 | 138/18670 | 1e-04 | 0.0018 | 19 |
GO:0046777 | protein autophosphorylation | 27/979 | 235/18670 | 1e-04 | 0.0018 | 27 |
GO:0002886 | regulation of myeloid leukocyte mediated immunity | 11/979 | 55/18670 | 1e-04 | 0.0018 | 11 |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 28/979 | 248/18670 | 1e-04 | 0.0019 | 28 |
GO:0045089 | positive regulation of innate immune response | 38/979 | 381/18670 | 1e-04 | 0.0019 | 38 |
GO:0007569 | cell aging | 17/979 | 116/18670 | 1e-04 | 0.0019 | 17 |
GO:0060249 | anatomical structure homeostasis | 42/979 | 437/18670 | 1e-04 | 0.0019 | 42 |
GO:0045137 | development of primary sexual characteristics | 26/979 | 223/18670 | 1e-04 | 0.0019 | 26 |
GO:0051960 | regulation of nervous system development | 75/979 | 927/18670 | 1e-04 | 0.0019 | 75 |
GO:0016572 | histone phosphorylation | 9/979 | 38/18670 | 1e-04 | 0.0019 | 9 |
GO:0051588 | regulation of neurotransmitter transport | 19/979 | 139/18670 | 1e-04 | 0.0019 | 19 |
GO:1901987 | regulation of cell cycle phase transition | 45/979 | 480/18670 | 1e-04 | 0.0019 | 45 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15/979 | 95/18670 | 1e-04 | 0.0019 | 15 |
GO:0051651 | maintenance of location in cell | 15/979 | 95/18670 | 1e-04 | 0.0019 | 15 |
GO:0051952 | regulation of amine transport | 15/979 | 95/18670 | 1e-04 | 0.0019 | 15 |
GO:0097193 | intrinsic apoptotic signaling pathway | 31/979 | 289/18670 | 1e-04 | 0.0021 | 31 |
GO:0098586 | cellular response to virus | 11/979 | 56/18670 | 1e-04 | 0.0021 | 11 |
GO:0050851 | antigen receptor-mediated signaling pathway | 33/979 | 316/18670 | 1e-04 | 0.0021 | 33 |
GO:0090277 | positive regulation of peptide hormone secretion | 15/979 | 96/18670 | 1e-04 | 0.0022 | 15 |
GO:0051048 | negative regulation of secretion | 27/979 | 238/18670 | 1e-04 | 0.0022 | 27 |
GO:0000380 | alternative mRNA splicing, via spliceosome | 13/979 | 76/18670 | 1e-04 | 0.0023 | 13 |
GO:0048598 | embryonic morphogenesis | 52/979 | 586/18670 | 1e-04 | 0.0023 | 52 |
GO:0002888 | positive regulation of myeloid leukocyte mediated immunity | 8/979 | 31/18670 | 1e-04 | 0.0023 | 8 |
GO:0050900 | leukocyte migration | 46/979 | 499/18670 | 1e-04 | 0.0023 | 46 |
GO:0046034 | ATP metabolic process | 32/979 | 305/18670 | 2e-04 | 0.0024 | 32 |
GO:0070848 | response to growth factor | 62/979 | 736/18670 | 2e-04 | 0.0024 | 62 |
GO:0009746 | response to hexose | 24/979 | 202/18670 | 2e-04 | 0.0024 | 24 |
GO:0051052 | regulation of DNA metabolic process | 41/979 | 429/18670 | 2e-04 | 0.0024 | 41 |
GO:0002218 | activation of innate immune response | 33/979 | 319/18670 | 2e-04 | 0.0025 | 33 |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 25/979 | 215/18670 | 2e-04 | 0.0025 | 25 |
GO:0060047 | heart contraction | 30/979 | 280/18670 | 2e-04 | 0.0026 | 30 |
GO:0033119 | negative regulation of RNA splicing | 7/979 | 24/18670 | 2e-04 | 0.0026 | 7 |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 34/979 | 334/18670 | 2e-04 | 0.0026 | 34 |
GO:0070997 | neuron death | 35/979 | 348/18670 | 2e-04 | 0.0027 | 35 |
GO:0008361 | regulation of cell size | 22/979 | 179/18670 | 2e-04 | 0.0027 | 22 |
GO:0051099 | positive regulation of binding | 22/979 | 179/18670 | 2e-04 | 0.0027 | 22 |
GO:0010976 | positive regulation of neuron projection development | 30/979 | 281/18670 | 2e-04 | 0.0027 | 30 |
GO:0022409 | positive regulation of cell-cell adhesion | 28/979 | 255/18670 | 2e-04 | 0.0027 | 28 |
GO:0045921 | positive regulation of exocytosis | 14/979 | 88/18670 | 2e-04 | 0.0028 | 14 |
GO:0008406 | gonad development | 25/979 | 217/18670 | 2e-04 | 0.0028 | 25 |
GO:0071322 | cellular response to carbohydrate stimulus | 19/979 | 144/18670 | 2e-04 | 0.0029 | 19 |
GO:0044257 | cellular protein catabolic process | 64/979 | 773/18670 | 2e-04 | 0.0030 | 64 |
GO:0042060 | wound healing | 50/979 | 564/18670 | 2e-04 | 0.0030 | 50 |
GO:0010564 | regulation of cell cycle process | 65/979 | 789/18670 | 2e-04 | 0.0030 | 65 |
GO:0007159 | leukocyte cell-cell adhesion | 34/979 | 337/18670 | 2e-04 | 0.0030 | 34 |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 46/979 | 506/18670 | 2e-04 | 0.0030 | 46 |
GO:0045165 | cell fate commitment | 29/979 | 270/18670 | 2e-04 | 0.0030 | 29 |
GO:0006897 | endocytosis | 67/979 | 820/18670 | 2e-04 | 0.0030 | 67 |
GO:0098660 | inorganic ion transmembrane transport | 68/979 | 836/18670 | 2e-04 | 0.0031 | 68 |
GO:1903522 | regulation of blood circulation | 31/979 | 297/18670 | 2e-04 | 0.0031 | 31 |
GO:0032890 | regulation of organic acid transport | 11/979 | 59/18670 | 2e-04 | 0.0031 | 11 |
GO:0051051 | negative regulation of transport | 47/979 | 522/18670 | 2e-04 | 0.0032 | 47 |
GO:1903312 | negative regulation of mRNA metabolic process | 13/979 | 79/18670 | 2e-04 | 0.0032 | 13 |
GO:0039535 | regulation of RIG-I signaling pathway | 6/979 | 18/18670 | 2e-04 | 0.0032 | 6 |
GO:0043406 | positive regulation of MAP kinase activity | 28/979 | 258/18670 | 2e-04 | 0.0032 | 28 |
GO:0050804 | modulation of chemical synaptic transmission | 41/979 | 436/18670 | 2e-04 | 0.0032 | 41 |
GO:0050434 | positive regulation of viral transcription | 9/979 | 41/18670 | 2e-04 | 0.0032 | 9 |
GO:0046683 | response to organophosphorus | 18/979 | 134/18670 | 2e-04 | 0.0032 | 18 |
GO:0007346 | regulation of mitotic cell cycle | 56/979 | 656/18670 | 2e-04 | 0.0033 | 56 |
GO:0051384 | response to glucocorticoid | 19/979 | 146/18670 | 2e-04 | 0.0033 | 19 |
GO:0099177 | regulation of trans-synaptic signaling | 41/979 | 437/18670 | 2e-04 | 0.0033 | 41 |
GO:0048872 | homeostasis of number of cells | 27/979 | 246/18670 | 2e-04 | 0.0034 | 27 |
GO:0018279 | protein N-linked glycosylation via asparagine | 8/979 | 33/18670 | 2e-04 | 0.0034 | 8 |
GO:2000147 | positive regulation of cell motility | 50/979 | 568/18670 | 2e-04 | 0.0034 | 50 |
GO:0038061 | NIK/NF-kappaB signaling | 22/979 | 183/18670 | 2e-04 | 0.0035 | 22 |
GO:0050792 | regulation of viral process | 24/979 | 208/18670 | 2e-04 | 0.0035 | 24 |
GO:0010506 | regulation of autophagy | 33/979 | 327/18670 | 3e-04 | 0.0035 | 33 |
GO:0051236 | establishment of RNA localization | 23/979 | 196/18670 | 3e-04 | 0.0036 | 23 |
GO:0007599 | hemostasis | 34/979 | 341/18670 | 3e-04 | 0.0036 | 34 |
GO:0046717 | acid secretion | 17/979 | 124/18670 | 3e-04 | 0.0036 | 17 |
GO:0045639 | positive regulation of myeloid cell differentiation | 14/979 | 91/18670 | 3e-04 | 0.0037 | 14 |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 16/979 | 113/18670 | 3e-04 | 0.0037 | 16 |
GO:0043903 | regulation of symbiosis, encompassing mutualism through parasitism | 25/979 | 222/18670 | 3e-04 | 0.0037 | 25 |
GO:0071326 | cellular response to monosaccharide stimulus | 18/979 | 136/18670 | 3e-04 | 0.0037 | 18 |
GO:0019369 | arachidonic acid metabolic process | 10/979 | 51/18670 | 3e-04 | 0.0037 | 10 |
GO:0050817 | coagulation | 34/979 | 342/18670 | 3e-04 | 0.0037 | 34 |
GO:0060560 | developmental growth involved in morphogenesis | 26/979 | 235/18670 | 3e-04 | 0.0037 | 26 |
GO:0009749 | response to glucose | 23/979 | 197/18670 | 3e-04 | 0.0038 | 23 |
GO:0015850 | organic hydroxy compound transport | 28/979 | 262/18670 | 3e-04 | 0.0039 | 28 |
GO:0007369 | gastrulation | 22/979 | 185/18670 | 3e-04 | 0.0039 | 22 |
GO:0048645 | animal organ formation | 11/979 | 61/18670 | 3e-04 | 0.0040 | 11 |
GO:0018196 | peptidyl-asparagine modification | 8/979 | 34/18670 | 3e-04 | 0.0040 | 8 |
GO:0032892 | positive regulation of organic acid transport | 8/979 | 34/18670 | 3e-04 | 0.0040 | 8 |
GO:0035967 | cellular response to topologically incorrect protein | 20/979 | 161/18670 | 3e-04 | 0.0040 | 20 |
GO:0032091 | negative regulation of protein binding | 15/979 | 103/18670 | 3e-04 | 0.0041 | 15 |
GO:0046641 | positive regulation of alpha-beta T cell proliferation | 6/979 | 19/18670 | 3e-04 | 0.0041 | 6 |
GO:0048025 | negative regulation of mRNA splicing, via spliceosome | 6/979 | 19/18670 | 3e-04 | 0.0041 | 6 |
GO:1990182 | exosomal secretion | 6/979 | 19/18670 | 3e-04 | 0.0041 | 6 |
GO:0022900 | electron transport chain | 22/979 | 186/18670 | 3e-04 | 0.0041 | 22 |
GO:0003015 | heart process | 30/979 | 290/18670 | 3e-04 | 0.0041 | 30 |
GO:0050708 | regulation of protein secretion | 43/979 | 472/18670 | 3e-04 | 0.0041 | 43 |
GO:0032479 | regulation of type I interferon production | 17/979 | 126/18670 | 3e-04 | 0.0041 | 17 |
GO:0071214 | cellular response to abiotic stimulus | 33/979 | 331/18670 | 3e-04 | 0.0041 | 33 |
GO:0104004 | cellular response to environmental stimulus | 33/979 | 331/18670 | 3e-04 | 0.0041 | 33 |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 31/979 | 304/18670 | 3e-04 | 0.0042 | 31 |
GO:0017038 | protein import | 23/979 | 199/18670 | 3e-04 | 0.0042 | 23 |
GO:0035966 | response to topologically incorrect protein | 23/979 | 199/18670 | 3e-04 | 0.0042 | 23 |
GO:0031960 | response to corticosteroid | 20/979 | 162/18670 | 3e-04 | 0.0042 | 20 |
GO:0003009 | skeletal muscle contraction | 9/979 | 43/18670 | 3e-04 | 0.0042 | 9 |
GO:0034383 | low-density lipoprotein particle clearance | 9/979 | 43/18670 | 3e-04 | 0.0042 | 9 |
GO:1904646 | cellular response to amyloid-beta | 9/979 | 43/18670 | 3e-04 | 0.0042 | 9 |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 43/979 | 473/18670 | 3e-04 | 0.0042 | 43 |
GO:0009410 | response to xenobiotic stimulus | 30/979 | 292/18670 | 3e-04 | 0.0045 | 30 |
GO:0043632 | modification-dependent macromolecule catabolic process | 54/979 | 637/18670 | 3e-04 | 0.0045 | 54 |
GO:0045785 | positive regulation of cell adhesion | 38/979 | 403/18670 | 4e-04 | 0.0045 | 38 |
GO:0031115 | negative regulation of microtubule polymerization | 5/979 | 13/18670 | 4e-04 | 0.0046 | 5 |
GO:0051656 | establishment of organelle localization | 45/979 | 504/18670 | 4e-04 | 0.0046 | 45 |
GO:0016055 | Wnt signaling pathway | 46/979 | 519/18670 | 4e-04 | 0.0046 | 46 |
GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 16/979 | 116/18670 | 4e-04 | 0.0046 | 16 |
GO:1900180 | regulation of protein localization to nucleus | 16/979 | 116/18670 | 4e-04 | 0.0046 | 16 |
GO:0006970 | response to osmotic stress | 13/979 | 83/18670 | 4e-04 | 0.0046 | 13 |
GO:0006986 | response to unfolded protein | 21/979 | 176/18670 | 4e-04 | 0.0047 | 21 |
GO:0032606 | type I interferon production | 17/979 | 128/18670 | 4e-04 | 0.0048 | 17 |
GO:0034620 | cellular response to unfolded protein | 18/979 | 140/18670 | 4e-04 | 0.0049 | 18 |
GO:0072331 | signal transduction by p53 class mediator | 28/979 | 267/18670 | 4e-04 | 0.0049 | 28 |
GO:1901988 | negative regulation of cell cycle phase transition | 28/979 | 267/18670 | 4e-04 | 0.0049 | 28 |
GO:0010463 | mesenchymal cell proliferation | 9/979 | 44/18670 | 4e-04 | 0.0049 | 9 |
GO:0042987 | amyloid precursor protein catabolic process | 9/979 | 44/18670 | 4e-04 | 0.0049 | 9 |
GO:0046688 | response to copper ion | 9/979 | 44/18670 | 4e-04 | 0.0049 | 9 |
GO:0098609 | cell-cell adhesion | 67/979 | 839/18670 | 4e-04 | 0.0049 | 67 |
GO:0031349 | positive regulation of defense response | 46/979 | 521/18670 | 4e-04 | 0.0049 | 46 |
GO:0198738 | cell-cell signaling by wnt | 46/979 | 521/18670 | 4e-04 | 0.0049 | 46 |
GO:0042391 | regulation of membrane potential | 40/979 | 434/18670 | 4e-04 | 0.0049 | 40 |
GO:0022904 | respiratory electron transport chain | 16/979 | 117/18670 | 4e-04 | 0.0050 | 16 |
GO:0015931 | nucleobase-containing compound transport | 26/979 | 241/18670 | 4e-04 | 0.0050 | 26 |
GO:0016311 | dephosphorylation | 43/979 | 478/18670 | 4e-04 | 0.0050 | 43 |
GO:0007596 | blood coagulation | 33/979 | 336/18670 | 4e-04 | 0.0051 | 33 |
GO:0039529 | RIG-I signaling pathway | 6/979 | 20/18670 | 4e-04 | 0.0051 | 6 |
GO:0042053 | regulation of dopamine metabolic process | 6/979 | 20/18670 | 4e-04 | 0.0051 | 6 |
GO:0042069 | regulation of catecholamine metabolic process | 6/979 | 20/18670 | 4e-04 | 0.0051 | 6 |
GO:0097734 | extracellular exosome biogenesis | 6/979 | 20/18670 | 4e-04 | 0.0051 | 6 |
GO:0001738 | morphogenesis of a polarized epithelium | 18/979 | 141/18670 | 4e-04 | 0.0051 | 18 |
GO:1904645 | response to amyloid-beta | 10/979 | 54/18670 | 4e-04 | 0.0053 | 10 |
GO:0034762 | regulation of transmembrane transport | 49/979 | 568/18670 | 4e-04 | 0.0053 | 49 |
GO:0030104 | water homeostasis | 12/979 | 74/18670 | 4e-04 | 0.0053 | 12 |
GO:0040017 | positive regulation of locomotion | 51/979 | 598/18670 | 4e-04 | 0.0053 | 51 |
GO:1903827 | regulation of cellular protein localization | 46/979 | 524/18670 | 4e-04 | 0.0054 | 46 |
GO:0000209 | protein polyubiquitination | 31/979 | 310/18670 | 4e-04 | 0.0054 | 31 |
GO:0002244 | hematopoietic progenitor cell differentiation | 20/979 | 166/18670 | 4e-04 | 0.0054 | 20 |
GO:0046782 | regulation of viral transcription | 11/979 | 64/18670 | 4e-04 | 0.0054 | 11 |
GO:0034764 | positive regulation of transmembrane transport | 23/979 | 204/18670 | 5e-04 | 0.0055 | 23 |
GO:0017157 | regulation of exocytosis | 24/979 | 217/18670 | 5e-04 | 0.0055 | 24 |
GO:0044087 | regulation of cellular component biogenesis | 74/979 | 954/18670 | 5e-04 | 0.0055 | 74 |
GO:0006611 | protein export from nucleus | 21/979 | 179/18670 | 5e-04 | 0.0056 | 21 |
GO:0098662 | inorganic cation transmembrane transport | 61/979 | 752/18670 | 5e-04 | 0.0056 | 61 |
GO:0050686 | negative regulation of mRNA processing | 7/979 | 28/18670 | 5e-04 | 0.0057 | 7 |
GO:0051123 | RNA polymerase II preinitiation complex assembly | 7/979 | 28/18670 | 5e-04 | 0.0057 | 7 |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 19/979 | 155/18670 | 5e-04 | 0.0058 | 19 |
GO:0006353 | DNA-templated transcription, termination | 12/979 | 75/18670 | 5e-04 | 0.0059 | 12 |
GO:0030162 | regulation of proteolysis | 66/979 | 831/18670 | 5e-04 | 0.0059 | 66 |
GO:1901796 | regulation of signal transduction by p53 class mediator | 21/979 | 180/18670 | 5e-04 | 0.0059 | 21 |
GO:0009167 | purine ribonucleoside monophosphate metabolic process | 33/979 | 340/18670 | 5e-04 | 0.0059 | 33 |
GO:0032526 | response to retinoic acid | 15/979 | 108/18670 | 5e-04 | 0.0059 | 15 |
GO:0050657 | nucleic acid transport | 22/979 | 193/18670 | 5e-04 | 0.0060 | 22 |
GO:0050658 | RNA transport | 22/979 | 193/18670 | 5e-04 | 0.0060 | 22 |
GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 11/979 | 65/18670 | 5e-04 | 0.0060 | 11 |
GO:0032760 | positive regulation of tumor necrosis factor production | 13/979 | 86/18670 | 5e-04 | 0.0060 | 13 |
GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 14/979 | 97/18670 | 5e-04 | 0.0060 | 14 |
GO:0051591 | response to cAMP | 14/979 | 97/18670 | 5e-04 | 0.0060 | 14 |
GO:0031346 | positive regulation of cell projection organization | 36/979 | 383/18670 | 5e-04 | 0.0061 | 36 |
GO:0016049 | cell growth | 43/979 | 484/18670 | 5e-04 | 0.0061 | 43 |
GO:0009126 | purine nucleoside monophosphate metabolic process | 33/979 | 341/18670 | 5e-04 | 0.0061 | 33 |
GO:0042129 | regulation of T cell proliferation | 19/979 | 156/18670 | 5e-04 | 0.0062 | 19 |
GO:0042177 | negative regulation of protein catabolic process | 17/979 | 132/18670 | 5e-04 | 0.0062 | 17 |
GO:0051129 | negative regulation of cellular component organization | 60/979 | 741/18670 | 5e-04 | 0.0063 | 60 |
GO:0030335 | positive regulation of cell migration | 47/979 | 544/18670 | 5e-04 | 0.0063 | 47 |
GO:2000142 | regulation of DNA-templated transcription, initiation | 8/979 | 37/18670 | 6e-04 | 0.0063 | 8 |
GO:0051168 | nuclear export | 22/979 | 194/18670 | 6e-04 | 0.0063 | 22 |
GO:0019058 | viral life cycle | 32/979 | 328/18670 | 6e-04 | 0.0063 | 32 |
GO:0006289 | nucleotide-excision repair | 15/979 | 109/18670 | 6e-04 | 0.0063 | 15 |
GO:0002438 | acute inflammatory response to antigenic stimulus | 6/979 | 21/18670 | 6e-04 | 0.0063 | 6 |
GO:0014821 | phasic smooth muscle contraction | 6/979 | 21/18670 | 6e-04 | 0.0063 | 6 |
GO:0039531 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 6/979 | 21/18670 | 6e-04 | 0.0063 | 6 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 52/979 | 620/18670 | 6e-04 | 0.0064 | 52 |
GO:0042773 | ATP synthesis coupled electron transport | 14/979 | 98/18670 | 6e-04 | 0.0065 | 14 |
GO:0050848 | regulation of calcium-mediated signaling | 14/979 | 98/18670 | 6e-04 | 0.0065 | 14 |
GO:0051480 | regulation of cytosolic calcium ion concentration | 34/979 | 357/18670 | 6e-04 | 0.0066 | 34 |
GO:0050879 | multicellular organismal movement | 10/979 | 56/18670 | 6e-04 | 0.0066 | 10 |
GO:0050881 | musculoskeletal movement | 10/979 | 56/18670 | 6e-04 | 0.0066 | 10 |
GO:0071333 | cellular response to glucose stimulus | 17/979 | 133/18670 | 6e-04 | 0.0066 | 17 |
GO:0050670 | regulation of lymphocyte proliferation | 23/979 | 208/18670 | 6e-04 | 0.0066 | 23 |
GO:0002697 | regulation of immune effector process | 41/979 | 458/18670 | 6e-04 | 0.0067 | 41 |
GO:0006939 | smooth muscle contraction | 15/979 | 110/18670 | 6e-04 | 0.0068 | 15 |
GO:0033559 | unsaturated fatty acid metabolic process | 15/979 | 110/18670 | 6e-04 | 0.0068 | 15 |
GO:0051235 | maintenance of location | 32/979 | 330/18670 | 6e-04 | 0.0068 | 32 |
GO:0050770 | regulation of axonogenesis | 21/979 | 183/18670 | 6e-04 | 0.0069 | 21 |
GO:0032481 | positive regulation of type I interferon production | 12/979 | 77/18670 | 6e-04 | 0.0069 | 12 |
GO:0048678 | response to axon injury | 12/979 | 77/18670 | 6e-04 | 0.0069 | 12 |
GO:0051851 | modification by host of symbiont morphology or physiology | 12/979 | 77/18670 | 6e-04 | 0.0069 | 12 |
GO:0070663 | regulation of leukocyte proliferation | 24/979 | 222/18670 | 6e-04 | 0.0070 | 24 |
GO:0032944 | regulation of mononuclear cell proliferation | 23/979 | 209/18670 | 6e-04 | 0.0070 | 23 |
GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 13/979 | 88/18670 | 6e-04 | 0.0071 | 13 |
GO:0030334 | regulation of cell migration | 73/979 | 950/18670 | 7e-04 | 0.0071 | 73 |
GO:0045926 | negative regulation of growth | 26/979 | 249/18670 | 7e-04 | 0.0071 | 26 |
GO:0007411 | axon guidance | 28/979 | 276/18670 | 7e-04 | 0.0071 | 28 |
GO:0051590 | positive regulation of neurotransmitter transport | 8/979 | 38/18670 | 7e-04 | 0.0072 | 8 |
GO:0051650 | establishment of vesicle localization | 29/979 | 290/18670 | 7e-04 | 0.0072 | 29 |
GO:0055114 | oxidation-reduction process | 76/979 | 999/18670 | 7e-04 | 0.0073 | 76 |
GO:0022037 | metencephalon development | 15/979 | 111/18670 | 7e-04 | 0.0073 | 15 |
GO:0097529 | myeloid leukocyte migration | 23/979 | 210/18670 | 7e-04 | 0.0073 | 23 |
GO:0002262 | myeloid cell homeostasis | 18/979 | 147/18670 | 7e-04 | 0.0074 | 18 |
GO:0097485 | neuron projection guidance | 28/979 | 277/18670 | 7e-04 | 0.0074 | 28 |
GO:0006405 | RNA export from nucleus | 17/979 | 135/18670 | 7e-04 | 0.0075 | 17 |
GO:0071331 | cellular response to hexose stimulus | 17/979 | 135/18670 | 7e-04 | 0.0075 | 17 |
GO:0046649 | lymphocyte activation | 59/979 | 733/18670 | 7e-04 | 0.0075 | 59 |
GO:0070498 | interleukin-1-mediated signaling pathway | 14/979 | 100/18670 | 7e-04 | 0.0075 | 14 |
GO:0019941 | modification-dependent protein catabolic process | 52/979 | 626/18670 | 7e-04 | 0.0075 | 52 |
GO:0090066 | regulation of anatomical structure size | 44/979 | 506/18670 | 7e-04 | 0.0075 | 44 |
GO:1902532 | negative regulation of intracellular signal transduction | 48/979 | 566/18670 | 7e-04 | 0.0076 | 48 |
GO:0031099 | regeneration | 22/979 | 198/18670 | 7e-04 | 0.0077 | 22 |
GO:0009314 | response to radiation | 40/979 | 448/18670 | 7e-04 | 0.0078 | 40 |
GO:0140112 | extracellular vesicle biogenesis | 6/979 | 22/18670 | 7e-04 | 0.0078 | 6 |
GO:0008016 | regulation of heart contraction | 26/979 | 251/18670 | 7e-04 | 0.0078 | 26 |
GO:0006354 | DNA-templated transcription, elongation | 15/979 | 112/18670 | 7e-04 | 0.0078 | 15 |
GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | 5/979 | 15/18670 | 8e-04 | 0.0079 | 5 |
GO:0017014 | protein nitrosylation | 5/979 | 15/18670 | 8e-04 | 0.0079 | 5 |
GO:0018119 | peptidyl-cysteine S-nitrosylation | 5/979 | 15/18670 | 8e-04 | 0.0079 | 5 |
GO:0032648 | regulation of interferon-beta production | 9/979 | 48/18670 | 8e-04 | 0.0079 | 9 |
GO:0097006 | regulation of plasma lipoprotein particle levels | 14/979 | 101/18670 | 8e-04 | 0.0081 | 14 |
GO:0098930 | axonal transport | 10/979 | 58/18670 | 8e-04 | 0.0082 | 10 |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 32/979 | 335/18670 | 8e-04 | 0.0083 | 32 |
GO:0051402 | neuron apoptotic process | 25/979 | 239/18670 | 8e-04 | 0.0083 | 25 |
GO:0015844 | monoamine transport | 13/979 | 90/18670 | 8e-04 | 0.0083 | 13 |
GO:0030901 | midbrain development | 13/979 | 90/18670 | 8e-04 | 0.0083 | 13 |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 18/979 | 149/18670 | 8e-04 | 0.0084 | 18 |
GO:0014074 | response to purine-containing compound | 18/979 | 149/18670 | 8e-04 | 0.0084 | 18 |
GO:0043200 | response to amino acid | 15/979 | 113/18670 | 8e-04 | 0.0084 | 15 |
GO:0060964 | regulation of gene silencing by miRNA | 15/979 | 113/18670 | 8e-04 | 0.0084 | 15 |
GO:0010038 | response to metal ion | 34/979 | 364/18670 | 8e-04 | 0.0084 | 34 |
GO:0006979 | response to oxidative stress | 40/979 | 451/18670 | 8e-04 | 0.0085 | 40 |
GO:0043062 | extracellular structure organization | 38/979 | 422/18670 | 8e-04 | 0.0086 | 38 |
GO:0021549 | cerebellum development | 14/979 | 102/18670 | 9e-04 | 0.0088 | 14 |
GO:0006914 | autophagy | 43/979 | 496/18670 | 9e-04 | 0.0088 | 43 |
GO:0061919 | process utilizing autophagic mechanism | 43/979 | 496/18670 | 9e-04 | 0.0088 | 43 |
GO:0008088 | axo-dendritic transport | 11/979 | 69/18670 | 9e-04 | 0.0088 | 11 |
GO:0051924 | regulation of calcium ion transport | 26/979 | 254/18670 | 9e-04 | 0.0089 | 26 |
GO:2001020 | regulation of response to DNA damage stimulus | 23/979 | 214/18670 | 9e-04 | 0.0089 | 23 |
GO:0097755 | positive regulation of blood vessel diameter | 10/979 | 59/18670 | 9e-04 | 0.0091 | 10 |
GO:0070838 | divalent metal ion transport | 42/979 | 483/18670 | 9e-04 | 0.0094 | 42 |
GO:0042176 | regulation of protein catabolic process | 35/979 | 381/18670 | 9e-04 | 0.0094 | 35 |
GO:0050870 | positive regulation of T cell activation | 22/979 | 202/18670 | 1e-03 | 0.0095 | 22 |
GO:0001709 | cell fate determination | 8/979 | 40/18670 | 1e-03 | 0.0095 | 8 |
GO:0048259 | regulation of receptor-mediated endocytosis | 14/979 | 103/18670 | 1e-03 | 0.0095 | 14 |
GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | 6/979 | 23/18670 | 1e-03 | 0.0095 | 6 |
GO:0072215 | regulation of metanephros development | 6/979 | 23/18670 | 1e-03 | 0.0095 | 6 |
GO:2000637 | positive regulation of gene silencing by miRNA | 6/979 | 23/18670 | 1e-03 | 0.0095 | 6 |
GO:0010975 | regulation of neuron projection development | 43/979 | 499/18670 | 1e-03 | 0.0097 | 43 |
GO:0035270 | endocrine system development | 16/979 | 127/18670 | 1e-03 | 0.0098 | 16 |
GO:0071426 | ribonucleoprotein complex export from nucleus | 16/979 | 127/18670 | 1e-03 | 0.0098 | 16 |
GO:0048609 | multicellular organismal reproductive process | 65/979 | 838/18670 | 1e-03 | 0.0099 | 65 |
GO:0048871 | multicellular organismal homeostasis | 42/979 | 485/18670 | 1e-03 | 0.0099 | 42 |
GO:0050727 | regulation of inflammatory response | 42/979 | 485/18670 | 1e-03 | 0.0099 | 42 |
GO:0009161 | ribonucleoside monophosphate metabolic process | 33/979 | 354/18670 | 1e-03 | 0.0099 | 33 |
ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | Count |
---|---|---|---|---|---|---|
GO:0006521 | regulation of cellular amino acid metabolic process | 11/172 | 62/18670 | 0e+00 | 0.0000 | 11 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 13/172 | 108/18670 | 0e+00 | 0.0000 | 13 |
GO:0090175 | regulation of establishment of planar polarity | 13/172 | 110/18670 | 0e+00 | 0.0000 | 13 |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 12/172 | 93/18670 | 0e+00 | 0.0000 | 12 |
GO:0001736 | establishment of planar polarity | 13/172 | 124/18670 | 0e+00 | 0.0000 | 13 |
GO:0007164 | establishment of tissue polarity | 13/172 | 124/18670 | 0e+00 | 0.0000 | 13 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 13/172 | 127/18670 | 0e+00 | 0.0000 | 13 |
GO:0033238 | regulation of cellular amine metabolic process | 11/172 | 81/18670 | 0e+00 | 0.0000 | 11 |
GO:1902750 | negative regulation of cell cycle G2/M phase transition | 12/172 | 105/18670 | 0e+00 | 0.0000 | 12 |
GO:0001738 | morphogenesis of a polarized epithelium | 13/172 | 141/18670 | 0e+00 | 0.0000 | 13 |
GO:1902036 | regulation of hematopoietic stem cell differentiation | 10/172 | 72/18670 | 0e+00 | 0.0000 | 10 |
GO:0016579 | protein deubiquitination | 17/172 | 283/18670 | 0e+00 | 0.0000 | 17 |
GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 12/172 | 121/18670 | 0e+00 | 0.0000 | 12 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 11/172 | 96/18670 | 0e+00 | 0.0000 | 11 |
GO:0035567 | non-canonical Wnt signaling pathway | 13/172 | 150/18670 | 0e+00 | 0.0000 | 13 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 10/172 | 75/18670 | 0e+00 | 0.0000 | 10 |
GO:0070498 | interleukin-1-mediated signaling pathway | 11/172 | 100/18670 | 0e+00 | 0.0000 | 11 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 10/172 | 77/18670 | 0e+00 | 0.0000 | 10 |
GO:0070646 | protein modification by small protein removal | 17/172 | 299/18670 | 0e+00 | 0.0000 | 17 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 10/172 | 79/18670 | 0e+00 | 0.0000 | 10 |
GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10/172 | 81/18670 | 0e+00 | 0.0000 | 10 |
GO:0060218 | hematopoietic stem cell differentiation | 10/172 | 83/18670 | 0e+00 | 0.0000 | 10 |
GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 10/172 | 85/18670 | 0e+00 | 0.0000 | 10 |
GO:0071347 | cellular response to interleukin-1 | 13/172 | 179/18670 | 0e+00 | 0.0000 | 13 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19/172 | 419/18670 | 0e+00 | 0.0000 | 19 |
GO:1905330 | regulation of morphogenesis of an epithelium | 13/172 | 180/18670 | 0e+00 | 0.0000 | 13 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 10/172 | 95/18670 | 0e+00 | 0.0000 | 10 |
GO:0043632 | modification-dependent macromolecule catabolic process | 23/172 | 637/18670 | 0e+00 | 0.0000 | 23 |
GO:0000209 | protein polyubiquitination | 16/172 | 310/18670 | 0e+00 | 0.0000 | 16 |
GO:0044106 | cellular amine metabolic process | 11/172 | 129/18670 | 0e+00 | 0.0000 | 11 |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 13/172 | 196/18670 | 0e+00 | 0.0000 | 13 |
GO:0002218 | activation of innate immune response | 16/172 | 319/18670 | 0e+00 | 0.0000 | 16 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 12/172 | 167/18670 | 0e+00 | 0.0000 | 12 |
GO:1903311 | regulation of mRNA metabolic process | 16/172 | 324/18670 | 0e+00 | 0.0000 | 16 |
GO:0009308 | amine metabolic process | 11/172 | 138/18670 | 0e+00 | 0.0000 | 11 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 22/172 | 620/18670 | 0e+00 | 0.0000 | 22 |
GO:0070555 | response to interleukin-1 | 13/172 | 207/18670 | 0e+00 | 0.0000 | 13 |
GO:0019941 | modification-dependent protein catabolic process | 22/172 | 626/18670 | 0e+00 | 0.0000 | 22 |
GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 12/172 | 175/18670 | 0e+00 | 0.0000 | 12 |
GO:1902749 | regulation of cell cycle G2/M phase transition | 13/172 | 213/18670 | 0e+00 | 0.0000 | 13 |
GO:0010498 | proteasomal protein catabolic process | 19/172 | 477/18670 | 0e+00 | 0.0000 | 19 |
GO:0043488 | regulation of mRNA stability | 12/172 | 177/18670 | 0e+00 | 0.0000 | 12 |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 10/172 | 113/18670 | 0e+00 | 0.0000 | 10 |
GO:2000027 | regulation of animal organ morphogenesis | 14/172 | 253/18670 | 0e+00 | 0.0000 | 14 |
GO:0002758 | innate immune response-activating signal transduction | 15/172 | 298/18670 | 0e+00 | 0.0000 | 15 |
GO:0010565 | regulation of cellular ketone metabolic process | 12/172 | 181/18670 | 0e+00 | 0.0000 | 12 |
GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 10/172 | 116/18670 | 0e+00 | 0.0000 | 10 |
GO:2000736 | regulation of stem cell differentiation | 10/172 | 116/18670 | 0e+00 | 0.0000 | 10 |
GO:0019884 | antigen processing and presentation of exogenous antigen | 12/172 | 182/18670 | 0e+00 | 0.0000 | 12 |
GO:0043487 | regulation of RNA stability | 12/172 | 183/18670 | 0e+00 | 0.0000 | 12 |
GO:0019882 | antigen processing and presentation | 13/172 | 226/18670 | 0e+00 | 0.0000 | 13 |
GO:0048002 | antigen processing and presentation of peptide antigen | 12/172 | 189/18670 | 0e+00 | 0.0000 | 12 |
GO:0071453 | cellular response to oxygen levels | 13/172 | 234/18670 | 0e+00 | 0.0000 | 13 |
GO:0061013 | regulation of mRNA catabolic process | 12/172 | 199/18670 | 0e+00 | 0.0000 | 12 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 11/172 | 169/18670 | 0e+00 | 0.0000 | 11 |
GO:0045089 | positive regulation of innate immune response | 16/172 | 381/18670 | 0e+00 | 0.0000 | 16 |
GO:0000086 | G2/M transition of mitotic cell cycle | 13/172 | 247/18670 | 0e+00 | 0.0000 | 13 |
GO:0071456 | cellular response to hypoxia | 12/172 | 207/18670 | 0e+00 | 0.0000 | 12 |
GO:0042180 | cellular ketone metabolic process | 13/172 | 248/18670 | 0e+00 | 0.0000 | 13 |
GO:0044257 | cellular protein catabolic process | 23/172 | 773/18670 | 0e+00 | 0.0000 | 23 |
GO:0051603 | proteolysis involved in cellular protein catabolic process | 22/172 | 716/18670 | 0e+00 | 0.0000 | 22 |
GO:0070482 | response to oxygen levels | 16/172 | 394/18670 | 0e+00 | 0.0000 | 16 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 11/172 | 178/18670 | 0e+00 | 0.0000 | 11 |
GO:0036294 | cellular response to decreased oxygen levels | 12/172 | 217/18670 | 0e+00 | 0.0000 | 12 |
GO:0006401 | RNA catabolic process | 16/172 | 397/18670 | 0e+00 | 0.0000 | 16 |
GO:0038061 | NIK/NF-kappaB signaling | 11/172 | 183/18670 | 0e+00 | 0.0001 | 11 |
GO:0090263 | positive regulation of canonical Wnt signaling pathway | 10/172 | 147/18670 | 0e+00 | 0.0001 | 10 |
GO:0044839 | cell cycle G2/M phase transition | 13/172 | 266/18670 | 0e+00 | 0.0001 | 13 |
GO:0001666 | response to hypoxia | 15/172 | 359/18670 | 0e+00 | 0.0001 | 15 |
GO:0031349 | positive regulation of defense response | 18/172 | 521/18670 | 0e+00 | 0.0001 | 18 |
GO:0036293 | response to decreased oxygen levels | 15/172 | 370/18670 | 0e+00 | 0.0001 | 15 |
GO:0016567 | protein ubiquitination | 23/172 | 822/18670 | 0e+00 | 0.0001 | 23 |
GO:0038093 | Fc receptor signaling pathway | 12/172 | 241/18670 | 0e+00 | 0.0001 | 12 |
GO:0050852 | T cell receptor signaling pathway | 11/172 | 202/18670 | 0e+00 | 0.0001 | 11 |
GO:0032446 | protein modification by small protein conjugation | 24/172 | 906/18670 | 0e+00 | 0.0001 | 24 |
GO:0002244 | hematopoietic progenitor cell differentiation | 10/172 | 166/18670 | 0e+00 | 0.0001 | 10 |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 12/172 | 248/18670 | 0e+00 | 0.0001 | 12 |
GO:0030178 | negative regulation of Wnt signaling pathway | 11/172 | 210/18670 | 0e+00 | 0.0002 | 11 |
GO:0045088 | regulation of innate immune response | 16/172 | 452/18670 | 0e+00 | 0.0002 | 16 |
GO:0048863 | stem cell differentiation | 12/172 | 257/18670 | 0e+00 | 0.0002 | 12 |
GO:0062012 | regulation of small molecule metabolic process | 16/172 | 459/18670 | 0e+00 | 0.0002 | 16 |
GO:0030177 | positive regulation of Wnt signaling pathway | 10/172 | 179/18670 | 0e+00 | 0.0002 | 10 |
GO:0010948 | negative regulation of cell cycle process | 14/172 | 361/18670 | 0e+00 | 0.0002 | 14 |
GO:1901988 | negative regulation of cell cycle phase transition | 12/172 | 267/18670 | 0e+00 | 0.0003 | 12 |
GO:0006520 | cellular amino acid metabolic process | 14/172 | 366/18670 | 0e+00 | 0.0003 | 14 |
GO:0002253 | activation of immune response | 20/172 | 724/18670 | 0e+00 | 0.0004 | 20 |
GO:0030163 | protein catabolic process | 23/172 | 931/18670 | 0e+00 | 0.0006 | 23 |
GO:0071356 | cellular response to tumor necrosis factor | 12/172 | 291/18670 | 0e+00 | 0.0006 | 12 |
GO:1901361 | organic cyclic compound catabolic process | 20/172 | 745/18670 | 0e+00 | 0.0006 | 20 |
GO:0016071 | mRNA metabolic process | 22/172 | 877/18670 | 0e+00 | 0.0007 | 22 |
GO:0030097 | hemopoiesis | 22/172 | 887/18670 | 0e+00 | 0.0008 | 22 |
GO:0002757 | immune response-activating signal transduction | 18/172 | 641/18670 | 0e+00 | 0.0009 | 18 |
GO:0050778 | positive regulation of immune response | 22/172 | 902/18670 | 0e+00 | 0.0010 | 22 |
GO:0034655 | nucleobase-containing compound catabolic process | 18/172 | 648/18670 | 0e+00 | 0.0010 | 18 |
GO:0019439 | aromatic compound catabolic process | 19/172 | 712/18670 | 0e+00 | 0.0011 | 19 |
GO:0034612 | response to tumor necrosis factor | 12/172 | 312/18670 | 0e+00 | 0.0011 | 12 |
GO:0006402 | mRNA catabolic process | 13/172 | 364/18670 | 0e+00 | 0.0011 | 13 |
GO:1903706 | regulation of hemopoiesis | 15/172 | 475/18670 | 0e+00 | 0.0011 | 15 |
GO:0050851 | antigen receptor-mediated signaling pathway | 12/172 | 316/18670 | 0e+00 | 0.0012 | 12 |
GO:0002009 | morphogenesis of an epithelium | 16/172 | 537/18670 | 0e+00 | 0.0012 | 16 |
GO:0048534 | hematopoietic or lymphoid organ development | 22/172 | 929/18670 | 0e+00 | 0.0014 | 22 |
GO:0002764 | immune response-regulating signaling pathway | 18/172 | 675/18670 | 1e-04 | 0.0016 | 18 |
GO:0030104 | water homeostasis | 6/172 | 74/18670 | 1e-04 | 0.0019 | 6 |
GO:0060070 | canonical Wnt signaling pathway | 12/172 | 335/18670 | 1e-04 | 0.0020 | 12 |
GO:0034976 | response to endoplasmic reticulum stress | 11/172 | 285/18670 | 1e-04 | 0.0020 | 11 |
GO:0060828 | regulation of canonical Wnt signaling pathway | 11/172 | 286/18670 | 1e-04 | 0.0021 | 11 |
GO:0045930 | negative regulation of mitotic cell cycle | 12/172 | 338/18670 | 1e-04 | 0.0021 | 12 |
GO:0046700 | heterocycle catabolic process | 18/172 | 695/18670 | 1e-04 | 0.0022 | 18 |
GO:0044270 | cellular nitrogen compound catabolic process | 18/172 | 696/18670 | 1e-04 | 0.0022 | 18 |
GO:0031347 | regulation of defense response | 21/172 | 901/18670 | 1e-04 | 0.0024 | 21 |
GO:0016055 | Wnt signaling pathway | 15/172 | 519/18670 | 1e-04 | 0.0026 | 15 |
GO:0198738 | cell-cell signaling by wnt | 15/172 | 521/18670 | 1e-04 | 0.0027 | 15 |
GO:0002520 | immune system development | 22/172 | 985/18670 | 1e-04 | 0.0029 | 22 |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 14/172 | 473/18670 | 1e-04 | 0.0034 | 14 |
GO:0043687 | post-translational protein modification | 12/172 | 361/18670 | 1e-04 | 0.0036 | 12 |
GO:0048729 | tissue morphogenesis | 17/172 | 670/18670 | 2e-04 | 0.0041 | 17 |
GO:0031329 | regulation of cellular catabolic process | 20/172 | 871/18670 | 2e-04 | 0.0041 | 20 |
GO:0000165 | MAPK cascade | 21/172 | 958/18670 | 2e-04 | 0.0052 | 21 |
GO:0023014 | signal transduction by protein phosphorylation | 21/172 | 969/18670 | 2e-04 | 0.0060 | 21 |
GO:1901990 | regulation of mitotic cell cycle phase transition | 13/172 | 444/18670 | 2e-04 | 0.0063 | 13 |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 14/172 | 506/18670 | 3e-04 | 0.0064 | 14 |
GO:0009894 | regulation of catabolic process | 21/172 | 979/18670 | 3e-04 | 0.0067 | 21 |
GO:0050891 | multicellular organismal water homeostasis | 5/172 | 68/18670 | 4e-04 | 0.0099 | 5 |