In the two-group classification, AML samples are basically clustered together no matter rows are scaled are not. Samples can also be separated into three groups where ALL samples are separated into two subgroups.

Consensus heatmaps for three subgroups

In the three-group classification, when rows are scaled, only ATC:skmeans generates stable partition (1-PAC score = 0.96), while when rows are not scaled, no method generates stable partitions, as shown in Table 1 and Figure S11.1.

Table 1. 1-PAC scores of the consensus partitioning under each method (k = 3). Partitions with 1-PAC > 0.9 (numbers in red) are considered as stable partitions.
Rows are scaled Rows are unscaled
ATC:skmeans 0.96 0.78
SD:skmeans 0.74 0.81
MAD:skmeans 0.87 0.78
CV:skmeans 0.84 0.78
ATC:kmeans 0.55 0.77
SD:mclust 0.52 0.73
CV:mclust 0.64 0.72
SD:kmeans 0.69 0.71
MAD:mclust 0.56 0.7
CV:kmeans 0.74 0.68
ATC:pam 0.53 0.65
MAD:kmeans 0.72 0.64
MAD:pam 0.45 0.56
CV:pam 0.46 0.55
SD:pam 0.43 0.53
MAD:hclust 0.24 0.44
ATC:hclust 0.48 0.42
SD:hclust 0.24 0.42
SD:NMF 0.58 0.41
CV:hclust 0.23 0.38
MAD:NMF 0.48 0.38
CV:NMF 0.56 0.37
ATC:NMF 0.64 0.37
ATC:mclust 0.38 0.3



Rows are scaled

Figure S11.1A. Consensus heatmaps with three groups. Matrix rows are scaled.

Figure S11.1A. Consensus heatmaps with three groups. Matrix rows are scaled.

Rows are unscaled

Figure S11.1B. Consensus heatmaps with three groups. Matrix rows are unscaled.

Figure S11.1B. Consensus heatmaps with three groups. Matrix rows are unscaled.

We pick the three-group classification from ATC:skmeans for the scaled case because it is the only stable partition, and pick SD:skmeans for the unscaled case because it has the highest 1-PAC score although it is not a stable partition. Besides the AML/ALL annotation, the original Golub study also provides B-cell/T-cell annotation for the ALL samples. The cola classifications and the annotations are visualized in Figure S11.2.

Figure S11.2. Conseusus partitions from ATC:skmeans and SD:skmeans methods.

Figure S11.2. Conseusus partitions from ATC:skmeans and SD:skmeans methods.

To make it easier to describe, we term the classification from the scaled matrix as \(C_{s, 3}\) (or C_{s,3} if it cannot be rendered as math symbols) and the classification from the unscaled matrix as \(C_{u,3}\) (or C_{u,3}).

In Figure S11.2, we can observe that both classification \(C_{s, 3}\) and \(C_{u, 3}\) separate ALL samples into two groups, but the classifications are different. \(C_{u,3}\) separates ALL samples into two groups that fit very well with the B-cell/T-cell annotation while \(C_{s, 3}\) gives a new classification. Note in the Golub study, the B-cell/T-cell classification on ALL samples were based on SOM on the unscaled matrix, so it is expected that \(C_{u,3}\) agrees on the B-cell/T-cell classification, also there were no stability accessment on the classification in the original study.

In the PCA plots in Fgiure 3, all three groups are separated very well under \(C_{s, 3}\), while group 2 and group3 can hardly be separated under \(C_{u, 3}\).

Figure S11.3. PCA plots for visualizing the two-group classification. Classification on the left plot is from $C_{s,3}$ and on the right is from $C_{u,3}$.

Figure S11.3. PCA plots for visualizing the two-group classification. Classification on the left plot is from \(C_{s,3}\) and on the right is from \(C_{u,3}\).

Signature genes

Next we look at the significantly expressed genes under the two classifications, illustrated in Figure S11.4. Both classifications give amount of sigature genes, which is mainly due to the difference between ALL and AML. To see how different methods affect the classifiction on ALL samples, we should only look at the ALL samples, as described in the next section.

Rows are scaled

Figure S11.4A. Signature genes from C_{s,3}.

Figure S11.4A. Signature genes from C_{s,3}.

Row are unscaled

Figure S11.4B. Signature genes from C_{u,3}.

Figure S11.4B. Signature genes from C_{u,3}.

Only look at ALL samples

We remove the samples with class label 1 (which corresponds to AML samples) in both classifications, and we apply t-test between group 2 and group 3 samples. The significant genes under the two classifications are visualized as heatmaps in Figure S11.5.

Since now we only look at the two groups in the two classifications, we modify the symbols of the two classification to \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\).

A direct conclusion from Figure S11.5 is there are far more significant genes under \(C^{(2)}_{s,3}\) (1217 genes) than \(C^{(2)}_{u,3}\) (245 genes).

Figure S11.5. Significant genes between group 2 and 3 in the two classifications. Left: from $C^{(2)}_{s,3}$, right: from $C^{(2)}_{u,3}$.

Figure S11.5. Significant genes between group 2 and 3 in the two classifications. Left: from \(C^{(2)}_{s,3}\), right: from \(C^{(2)}_{u,3}\).

Since Figure S11.5 only shows the relative expression (the scaled expression), in Figure S11.6, we check the distribution of the absolute expression level of the signature genes in the two classifications, visualized in Figure S11.6. Figure S11.6 shows both signature genes are more enriched in the highly expressed genes, where signatures from \(C^{(2)}_{s,3}\) also cover genes with moderate expression levels.

Figure S11.6. Distribution of the absolute expression of signature genes. A and C: genes are ordered based on their base mean (mean expression among all samples) where significant genes are marked in blue and red. B and D: number of signatures that fall in every 20-gene interval, the same ordering on x-axes as Figure A and C.

Figure S11.6. Distribution of the absolute expression of signature genes. A and C: genes are ordered based on their base mean (mean expression among all samples) where significant genes are marked in blue and red. B and D: number of signatures that fall in every 20-gene interval, the same ordering on x-axes as Figure A and C.

The two sets of signature genes have very small overlap, illustrated in Figure S11.7.

Figure S11.7. Overlap of signature genes in $C^{(2)}_{s,3}$ and $C^{(2)}_{u,3}$.

Figure S11.7. Overlap of signature genes in \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\).

Similar as the analysis in the two-group classification, we check the biological functions that are enriched in the two sets of signature genes from \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\). Mainly because of the high amount of signature genes from \(C^{(2)}_{s,3}\), it has far more enriched GO functions than \(C^{(2)}_{u,3}\) (Figure S11.8).

Figure S11.8. Gene ontology enrichment on the two sets of signature genes illustrated in Figure S11.5.

Figure S11.8. Gene ontology enrichment on the two sets of signature genes illustrated in Figure S11.5.

Conclusion

As conclusions, it seems the classification from \(C^{(2)}_{s,3}\) is more reasonable because there are many signature genes as well as enriched biolofical functions, which might provide a new and different view to the B-cell/T-cell classification.

Gene ontology enrichment

\(C^{(2)}_{s,3}\) (608 terms)

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0009725 response to hormone 118/979 987/18670 0e+00 0.0000 118
GO:0010243 response to organonitrogen compound 115/979 998/18670 0e+00 0.0000 115
GO:0044419 interspecies interaction between organisms 105/979 932/18670 0e+00 0.0000 105
GO:1901699 cellular response to nitrogen compound 82/979 648/18670 0e+00 0.0000 82
GO:0019725 cellular homeostasis 107/979 970/18670 0e+00 0.0000 107
GO:0071417 cellular response to organonitrogen compound 75/979 585/18670 0e+00 0.0000 75
GO:0033993 response to lipid 101/979 923/18670 0e+00 0.0000 101
GO:0014070 response to organic cyclic compound 100/979 915/18670 0e+00 0.0000 100
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 84/979 719/18670 0e+00 0.0000 84
GO:0051050 positive regulation of transport 104/979 982/18670 0e+00 0.0000 104
GO:0044403 symbiont process 96/979 884/18670 0e+00 0.0000 96
GO:0032870 cellular response to hormone stimulus 81/979 701/18670 0e+00 0.0000 81
GO:0016032 viral process 91/979 833/18670 0e+00 0.0000 91
GO:1901652 response to peptide 66/979 520/18670 0e+00 0.0000 66
GO:0016071 mRNA metabolic process 94/979 877/18670 0e+00 0.0000 94
GO:0055082 cellular chemical homeostasis 87/979 812/18670 0e+00 0.0000 87
GO:0036293 response to decreased oxygen levels 51/979 370/18670 0e+00 0.0000 51
GO:0001666 response to hypoxia 50/979 359/18670 0e+00 0.0000 50
GO:0070482 response to oxygen levels 53/979 394/18670 0e+00 0.0000 53
GO:0019221 cytokine-mediated signaling pathway 84/979 798/18670 0e+00 0.0000 84
GO:0009894 regulation of catabolic process 97/979 979/18670 0e+00 0.0000 97
GO:0008015 blood circulation 64/979 541/18670 0e+00 0.0000 64
GO:1901653 cellular response to peptide 51/979 385/18670 0e+00 0.0000 51
GO:0051046 regulation of secretion 84/979 811/18670 0e+00 0.0000 84
GO:0003013 circulatory system process 64/979 551/18670 0e+00 0.0000 64
GO:1903311 regulation of mRNA metabolic process 45/979 324/18670 0e+00 0.0000 45
GO:0048534 hematopoietic or lymphoid organ development 92/979 929/18670 0e+00 0.0000 92
GO:0002520 immune system development 96/979 985/18670 0e+00 0.0000 96
GO:0048545 response to steroid hormone 50/979 385/18670 0e+00 0.0000 50
GO:0009611 response to wounding 73/979 678/18670 0e+00 0.0000 73
GO:0031329 regulation of cellular catabolic process 87/979 871/18670 0e+00 0.0000 87
GO:0000165 MAPK cascade 93/979 958/18670 0e+00 0.0000 93
GO:0008380 RNA splicing 56/979 469/18670 0e+00 0.0000 56
GO:0043620 regulation of DNA-templated transcription in response to stress 25/979 127/18670 0e+00 0.0000 25
GO:0048732 gland development 53/979 434/18670 0e+00 0.0000 53
GO:0030003 cellular cation homeostasis 70/979 652/18670 0e+00 0.0000 70
GO:0023014 signal transduction by protein phosphorylation 93/979 969/18670 0e+00 0.0000 93
GO:0009408 response to heat 30/979 176/18670 0e+00 0.0000 30
GO:0043434 response to peptide hormone 53/979 436/18670 0e+00 0.0000 53
GO:0030097 hemopoiesis 87/979 887/18670 0e+00 0.0000 87
GO:0009266 response to temperature stimulus 36/979 243/18670 0e+00 0.0000 36
GO:0055080 cation homeostasis 75/979 730/18670 0e+00 0.0000 75
GO:0051169 nuclear transport 45/979 346/18670 0e+00 0.0000 45
GO:0006873 cellular ion homeostasis 70/979 665/18670 0e+00 0.0000 70
GO:0033238 regulation of cellular amine metabolic process 19/979 81/18670 0e+00 0.0000 19
GO:0060341 regulation of cellular localization 87/979 906/18670 0e+00 0.0000 87
GO:1903530 regulation of secretion by cell 76/979 753/18670 0e+00 0.0000 76
GO:0098771 inorganic ion homeostasis 75/979 741/18670 0e+00 0.0000 75
GO:0048511 rhythmic process 40/979 295/18670 0e+00 0.0000 40
GO:0090087 regulation of peptide transport 74/979 729/18670 0e+00 0.0000 74
GO:0006913 nucleocytoplasmic transport 44/979 343/18670 0e+00 0.0000 44
GO:0071396 cellular response to lipid 65/979 610/18670 0e+00 0.0000 65
GO:0000375 RNA splicing, via transesterification reactions 47/979 382/18670 0e+00 0.0000 47
GO:0060322 head development 77/979 776/18670 0e+00 0.0000 77
GO:0046883 regulation of hormone secretion 37/979 266/18670 0e+00 0.0000 37
GO:0044706 multi-multicellular organism process 33/979 222/18670 0e+00 0.0000 33
GO:0033365 protein localization to organelle 87/979 922/18670 0e+00 0.0000 87
GO:0002444 myeloid leukocyte mediated immunity 60/979 551/18670 0e+00 0.0000 60
GO:0009636 response to toxic substance 58/979 525/18670 0e+00 0.0000 58
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 23/979 121/18670 0e+00 0.0000 23
GO:0023061 signal release 53/979 462/18670 0e+00 0.0000 53
GO:0006875 cellular metal ion homeostasis 62/979 579/18670 0e+00 0.0000 62
GO:0050852 T cell receptor signaling pathway 31/979 202/18670 0e+00 0.0000 31
GO:0002283 neutrophil activation involved in immune response 55/979 488/18670 0e+00 0.0000 55
GO:0006974 cellular response to DNA damage stimulus 82/979 854/18670 0e+00 0.0000 82
GO:0006397 mRNA processing 59/979 541/18670 0e+00 0.0000 59
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 46/979 379/18670 0e+00 0.0000 46
GO:0000398 mRNA splicing, via spliceosome 46/979 379/18670 0e+00 0.0000 46
GO:0043069 negative regulation of programmed cell death 87/979 932/18670 0e+00 0.0000 87
GO:0055065 metal ion homeostasis 67/979 653/18670 0e+00 0.0000 67
GO:0007409 axonogenesis 53/979 468/18670 0e+00 0.0000 53
GO:0030072 peptide hormone secretion 35/979 250/18670 0e+00 0.0000 35
GO:0035821 modification of morphology or physiology of other organism 27/979 164/18670 0e+00 0.0000 27
GO:0034976 response to endoplasmic reticulum stress 38/979 285/18670 0e+00 0.0000 38
GO:0071375 cellular response to peptide hormone stimulus 41/979 321/18670 0e+00 0.0000 41
GO:0008284 positive regulation of cell proliferation 88/979 951/18670 0e+00 0.0000 88
GO:0017144 drug metabolic process 81/979 851/18670 0e+00 0.0000 81
GO:0043408 regulation of MAPK cascade 75/979 768/18670 0e+00 0.0000 75
GO:0090276 regulation of peptide hormone secretion 31/979 208/18670 0e+00 0.0000 31
GO:0043312 neutrophil degranulation 54/979 485/18670 0e+00 0.0000 54
GO:0042119 neutrophil activation 55/979 498/18670 0e+00 0.0000 55
GO:0050801 ion homeostasis 78/979 811/18670 0e+00 0.0000 78
GO:2000027 regulation of animal organ morphogenesis 35/979 253/18670 0e+00 0.0000 35
GO:0043066 negative regulation of apoptotic process 85/979 911/18670 0e+00 0.0000 85
GO:0002446 neutrophil mediated immunity 55/979 499/18670 0e+00 0.0000 55
GO:0043488 regulation of mRNA stability 28/979 177/18670 0e+00 0.0000 28
GO:0046879 hormone secretion 40/979 312/18670 0e+00 0.0000 40
GO:0051098 regulation of binding 45/979 373/18670 0e+00 0.0000 45
GO:0061564 axon development 56/979 514/18670 0e+00 0.0000 56
GO:0050878 regulation of body fluid levels 55/979 501/18670 0e+00 0.0000 55
GO:0071407 cellular response to organic cyclic compound 58/979 542/18670 0e+00 0.0000 58
GO:0007420 brain development 72/979 733/18670 0e+00 0.0000 72
GO:0006887 exocytosis 84/979 903/18670 0e+00 0.0000 84
GO:0036230 granulocyte activation 55/979 504/18670 0e+00 0.0000 55
GO:1905330 regulation of morphogenesis of an epithelium 28/979 180/18670 0e+00 0.0000 28
GO:0033674 positive regulation of kinase activity 60/979 573/18670 0e+00 0.0000 60
GO:0007565 female pregnancy 29/979 192/18670 0e+00 0.0000 29
GO:0001101 response to acid chemical 42/979 343/18670 0e+00 0.0000 42
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 19/979 93/18670 0e+00 0.0000 19
GO:0019884 antigen processing and presentation of exogenous antigen 28/979 182/18670 0e+00 0.0000 28
GO:0006352 DNA-templated transcription, initiation 34/979 249/18670 0e+00 0.0000 34
GO:0043487 regulation of RNA stability 28/979 183/18670 0e+00 0.0000 28
GO:0043549 regulation of kinase activity 81/979 870/18670 0e+00 0.0000 81
GO:0006457 protein folding 32/979 227/18670 0e+00 0.0000 32
GO:0098657 import into cell 86/979 945/18670 0e+00 0.0000 86
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 17/979 77/18670 0e+00 0.0000 17
GO:0009914 hormone transport 40/979 322/18670 0e+00 0.0000 40
GO:1901361 organic cyclic compound catabolic process 72/979 745/18670 0e+00 0.0000 72
GO:0034655 nucleobase-containing compound catabolic process 65/979 648/18670 0e+00 0.0000 65
GO:0070201 regulation of establishment of protein localization 72/979 746/18670 0e+00 0.0000 72
GO:0045597 positive regulation of cell differentiation 89/979 991/18670 0e+00 0.0000 89
GO:0034612 response to tumor necrosis factor 39/979 312/18670 0e+00 0.0000 39
GO:0002478 antigen processing and presentation of exogenous peptide antigen 27/979 175/18670 0e+00 0.0000 27
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 19/979 96/18670 0e+00 0.0000 19
GO:0002275 myeloid cell activation involved in immune response 57/979 544/18670 0e+00 0.0000 57
GO:0009991 response to extracellular stimulus 56/979 531/18670 0e+00 0.0000 56
GO:0046700 heterocycle catabolic process 68/979 695/18670 0e+00 0.0000 68
GO:0072503 cellular divalent inorganic cation homeostasis 53/979 493/18670 0e+00 0.0000 53
GO:0071356 cellular response to tumor necrosis factor 37/979 291/18670 0e+00 0.0000 37
GO:0048729 tissue morphogenesis 66/979 670/18670 0e+00 0.0000 66
GO:0043299 leukocyte degranulation 56/979 534/18670 0e+00 0.0000 56
GO:0030522 intracellular receptor signaling pathway 36/979 280/18670 0e+00 0.0000 36
GO:0097190 apoptotic signaling pathway 61/979 602/18670 0e+00 0.0000 61
GO:0048002 antigen processing and presentation of peptide antigen 28/979 189/18670 0e+00 0.0000 28
GO:0071453 cellular response to oxygen levels 32/979 234/18670 0e+00 0.0000 32
GO:0006836 neurotransmitter transport 35/979 269/18670 0e+00 0.0000 35
GO:0009755 hormone-mediated signaling pathway 32/979 235/18670 0e+00 0.0000 32
GO:0009308 amine metabolic process 23/979 138/18670 0e+00 0.0000 23
GO:0031667 response to nutrient levels 53/979 499/18670 0e+00 0.0000 53
GO:0051347 positive regulation of transferase activity 64/979 649/18670 0e+00 0.0000 64
GO:0072507 divalent inorganic cation homeostasis 54/979 513/18670 0e+00 0.0000 54
GO:0032868 response to insulin 35/979 272/18670 0e+00 0.0000 35
GO:0006954 inflammatory response 78/979 848/18670 0e+00 0.0000 78
GO:0044106 cellular amine metabolic process 22/979 129/18670 0e+00 0.0000 22
GO:0007568 aging 39/979 321/18670 0e+00 0.0000 39
GO:0019882 antigen processing and presentation 31/979 226/18670 0e+00 0.0000 31
GO:0035567 non-canonical Wnt signaling pathway 24/979 150/18670 0e+00 0.0000 24
GO:0002790 peptide secretion 62/979 624/18670 0e+00 0.0000 62
GO:0071383 cellular response to steroid hormone stimulus 33/979 250/18670 0e+00 0.0000 33
GO:0034504 protein localization to nucleus 34/979 262/18670 0e+00 0.0000 34
GO:0032869 cellular response to insulin stimulus 30/979 216/18670 0e+00 0.0000 30
GO:0044270 cellular nitrogen compound catabolic process 67/979 696/18670 0e+00 0.0000 67
GO:0001819 positive regulation of cytokine production 50/979 464/18670 0e+00 0.0000 50
GO:0036294 cellular response to decreased oxygen levels 30/979 217/18670 0e+00 0.0000 30
GO:0032101 regulation of response to external stimulus 82/979 913/18670 0e+00 0.0000 82
GO:0019439 aromatic compound catabolic process 68/979 712/18670 0e+00 0.0000 68
GO:0042593 glucose homeostasis 32/979 241/18670 0e+00 0.0001 32
GO:0051170 import into nucleus 25/979 163/18670 0e+00 0.0001 25
GO:0070555 response to interleukin-1 29/979 207/18670 0e+00 0.0001 29
GO:0071456 cellular response to hypoxia 29/979 207/18670 0e+00 0.0001 29
GO:0051047 positive regulation of secretion 47/979 428/18670 0e+00 0.0001 47
GO:0033500 carbohydrate homeostasis 32/979 242/18670 0e+00 0.0001 32
GO:0050778 positive regulation of immune response 81/979 902/18670 0e+00 0.0001 81
GO:0031175 neuron projection development 86/979 978/18670 0e+00 0.0001 86
GO:0080135 regulation of cellular response to stress 70/979 746/18670 0e+00 0.0001 70
GO:0048608 reproductive structure development 47/979 431/18670 0e+00 0.0001 47
GO:0003006 developmental process involved in reproduction 65/979 676/18670 0e+00 0.0001 65
GO:0061013 regulation of mRNA catabolic process 28/979 199/18670 0e+00 0.0001 28
GO:0010720 positive regulation of cell development 56/979 553/18670 0e+00 0.0001 56
GO:0006367 transcription initiation from RNA polymerase II promoter 27/979 188/18670 0e+00 0.0001 27
GO:0040008 regulation of growth 65/979 679/18670 0e+00 0.0001 65
GO:0002274 myeloid leukocyte activation 63/979 651/18670 0e+00 0.0001 63
GO:1902750 negative regulation of cell cycle G2/M phase transition 19/979 105/18670 0e+00 0.0001 19
GO:0045055 regulated exocytosis 73/979 794/18670 0e+00 0.0001 73
GO:0061458 reproductive system development 47/979 434/18670 0e+00 0.0001 47
GO:0048667 cell morphogenesis involved in neuron differentiation 58/979 583/18670 0e+00 0.0001 58
GO:1903706 regulation of hemopoiesis 50/979 475/18670 0e+00 0.0001 50
GO:0009895 negative regulation of catabolic process 37/979 308/18670 0e+00 0.0001 37
GO:0006401 RNA catabolic process 44/979 397/18670 0e+00 0.0001 44
GO:0071347 cellular response to interleukin-1 26/979 179/18670 0e+00 0.0001 26
GO:0044057 regulation of system process 60/979 613/18670 0e+00 0.0001 60
GO:0034605 cellular response to heat 22/979 137/18670 0e+00 0.0001 22
GO:0051100 negative regulation of binding 25/979 169/18670 0e+00 0.0001 25
GO:0051223 regulation of protein transport 66/979 699/18670 0e+00 0.0001 66
GO:0045860 positive regulation of protein kinase activity 54/979 532/18670 0e+00 0.0001 54
GO:0043410 positive regulation of MAPK cascade 55/979 546/18670 0e+00 0.0001 55
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 16/979 79/18670 0e+00 0.0001 16
GO:0019932 second-messenger-mediated signaling 47/979 439/18670 0e+00 0.0001 47
GO:0000904 cell morphogenesis involved in differentiation 69/979 744/18670 0e+00 0.0001 69
GO:0006521 regulation of cellular amino acid metabolic process 14/979 62/18670 0e+00 0.0001 14
GO:0001504 neurotransmitter uptake 12/979 46/18670 0e+00 0.0001 12
GO:0008285 negative regulation of cell proliferation 70/979 760/18670 0e+00 0.0001 70
GO:0099536 synaptic signaling 67/979 717/18670 0e+00 0.0001 67
GO:0008217 regulation of blood pressure 26/979 182/18670 0e+00 0.0001 26
GO:0001816 cytokine production 72/979 790/18670 0e+00 0.0001 72
GO:0001944 vasculature development 72/979 792/18670 0e+00 0.0001 72
GO:0045859 regulation of protein kinase activity 72/979 792/18670 0e+00 0.0001 72
GO:0055074 calcium ion homeostasis 49/979 471/18670 0e+00 0.0001 49
GO:1902036 regulation of hematopoietic stem cell differentiation 15/979 72/18670 0e+00 0.0001 15
GO:0031145 anaphase-promoting complex-dependent catabolic process 16/979 81/18670 0e+00 0.0001 16
GO:0006874 cellular calcium ion homeostasis 48/979 458/18670 0e+00 0.0001 48
GO:0019373 epoxygenase P450 pathway 8/979 20/18670 0e+00 0.0001 8
GO:0030073 insulin secretion 28/979 207/18670 0e+00 0.0001 28
GO:0051338 regulation of transferase activity 84/979 972/18670 0e+00 0.0001 84
GO:0051090 regulation of DNA-binding transcription factor activity 46/979 432/18670 0e+00 0.0001 46
GO:0001505 regulation of neurotransmitter levels 40/979 354/18670 0e+00 0.0001 40
GO:0010389 regulation of G2/M transition of mitotic cell cycle 27/979 196/18670 0e+00 0.0001 27
GO:0002791 regulation of peptide secretion 51/979 500/18670 0e+00 0.0001 51
GO:0050769 positive regulation of neurogenesis 49/979 474/18670 0e+00 0.0001 49
GO:0010817 regulation of hormone levels 53/979 529/18670 0e+00 0.0001 53
GO:0072358 cardiovascular system development 72/979 801/18670 0e+00 0.0002 72
GO:0032386 regulation of intracellular transport 45/979 423/18670 0e+00 0.0002 45
GO:0060218 hematopoietic stem cell differentiation 16/979 83/18670 0e+00 0.0002 16
GO:0001525 angiogenesis 57/979 587/18670 0e+00 0.0002 57
GO:0035239 tube morphogenesis 80/979 920/18670 0e+00 0.0002 80
GO:0098810 neurotransmitter reuptake 9/979 27/18670 0e+00 0.0002 9
GO:0043902 positive regulation of multi-organism process 26/979 188/18670 0e+00 0.0002 26
GO:1903532 positive regulation of secretion by cell 43/979 399/18670 0e+00 0.0002 43
GO:0006936 muscle contraction 40/979 360/18670 0e+00 0.0002 40
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 15/979 75/18670 0e+00 0.0002 15
GO:0072594 establishment of protein localization to organelle 54/979 549/18670 0e+00 0.0002 54
GO:0001817 regulation of cytokine production 66/979 719/18670 0e+00 0.0002 66
GO:0010948 negative regulation of cell cycle process 40/979 361/18670 0e+00 0.0002 40
GO:0033209 tumor necrosis factor-mediated signaling pathway 24/979 167/18670 0e+00 0.0002 24
GO:1901532 regulation of hematopoietic progenitor cell differentiation 16/979 85/18670 0e+00 0.0002 16
GO:0045471 response to ethanol 20/979 125/18670 0e+00 0.0002 20
GO:0022407 regulation of cell-cell adhesion 43/979 403/18670 0e+00 0.0002 43
GO:0043270 positive regulation of ion transport 33/979 275/18670 0e+00 0.0002 33
GO:0032735 positive regulation of interleukin-12 production 10/979 35/18670 0e+00 0.0002 10
GO:0002253 activation of immune response 66/979 724/18670 0e+00 0.0002 66
GO:0038095 Fc-epsilon receptor signaling pathway 24/979 169/18670 0e+00 0.0002 24
GO:0048514 blood vessel morphogenesis 63/979 681/18670 0e+00 0.0002 63
GO:0006091 generation of precursor metabolites and energy 52/979 526/18670 0e+00 0.0002 52
GO:0009615 response to virus 37/979 326/18670 0e+00 0.0002 37
GO:0048013 ephrin receptor signaling pathway 16/979 86/18670 0e+00 0.0002 16
GO:0002443 leukocyte mediated immunity 76/979 874/18670 0e+00 0.0003 76
GO:0045786 negative regulation of cell cycle 60/979 641/18670 0e+00 0.0003 60
GO:0043269 regulation of ion transport 64/979 699/18670 0e+00 0.0003 64
GO:0043393 regulation of protein binding 28/979 217/18670 0e+00 0.0003 28
GO:0009060 aerobic respiration 16/979 87/18670 0e+00 0.0003 16
GO:0048524 positive regulation of viral process 18/979 107/18670 0e+00 0.0003 18
GO:0046794 transport of virus 13/979 60/18670 0e+00 0.0003 13
GO:0006403 RNA localization 29/979 230/18670 0e+00 0.0003 29
GO:0009743 response to carbohydrate 29/979 230/18670 0e+00 0.0003 29
GO:0001568 blood vessel development 68/979 761/18670 0e+00 0.0003 68
GO:0007268 chemical synaptic transmission 64/979 703/18670 0e+00 0.0003 64
GO:0098916 anterograde trans-synaptic signaling 64/979 703/18670 0e+00 0.0003 64
GO:0040007 growth 83/979 986/18670 0e+00 0.0003 83
GO:0048863 stem cell differentiation 31/979 257/18670 0e+00 0.0003 31
GO:0097305 response to alcohol 29/979 233/18670 0e+00 0.0003 29
GO:0007548 sex differentiation 32/979 270/18670 0e+00 0.0004 32
GO:0016579 protein deubiquitination 33/979 283/18670 0e+00 0.0004 33
GO:0002009 morphogenesis of an epithelium 52/979 537/18670 0e+00 0.0004 52
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 58/979 622/18670 0e+00 0.0004 58
GO:0031347 regulation of defense response 77/979 901/18670 0e+00 0.0004 77
GO:0046887 positive regulation of hormone secretion 20/979 131/18670 0e+00 0.0004 20
GO:0006281 DNA repair 53/979 552/18670 0e+00 0.0004 53
GO:0000086 G2/M transition of mitotic cell cycle 30/979 247/18670 0e+00 0.0004 30
GO:0050796 regulation of insulin secretion 24/979 176/18670 0e+00 0.0004 24
GO:0099537 trans-synaptic signaling 64/979 711/18670 0e+00 0.0004 64
GO:0006606 protein import into nucleus 21/979 143/18670 0e+00 0.0004 21
GO:0018105 peptidyl-serine phosphorylation 34/979 299/18670 0e+00 0.0004 34
GO:0070646 protein modification by small protein removal 34/979 299/18670 0e+00 0.0004 34
GO:0006402 mRNA catabolic process 39/979 364/18670 0e+00 0.0004 39
GO:1902749 regulation of cell cycle G2/M phase transition 27/979 213/18670 0e+00 0.0005 27
GO:0062012 regulation of small molecule metabolic process 46/979 459/18670 0e+00 0.0005 46
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 18/979 112/18670 0e+00 0.0005 18
GO:0015672 monovalent inorganic cation transport 51/979 529/18670 0e+00 0.0005 51
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 43/979 419/18670 0e+00 0.0005 43
GO:0043065 positive regulation of apoptotic process 61/979 672/18670 0e+00 0.0005 61
GO:0006935 chemotaxis 59/979 644/18670 0e+00 0.0005 59
GO:0046677 response to antibiotic 36/979 327/18670 0e+00 0.0005 36
GO:0044766 multi-organism transport 14/979 73/18670 0e+00 0.0005 14
GO:1902579 multi-organism localization 14/979 73/18670 0e+00 0.0005 14
GO:0044772 mitotic cell cycle phase transition 55/979 588/18670 0e+00 0.0005 55
GO:0031330 negative regulation of cellular catabolic process 31/979 264/18670 0e+00 0.0005 31
GO:0050767 regulation of neurogenesis 71/979 822/18670 0e+00 0.0005 71
GO:0042330 taxis 59/979 646/18670 0e+00 0.0005 59
GO:0002764 immune response-regulating signaling pathway 61/979 675/18670 0e+00 0.0005 61
GO:0060627 regulation of vesicle-mediated transport 51/979 532/18670 0e+00 0.0005 51
GO:0030001 metal ion transport 75/979 883/18670 0e+00 0.0005 75
GO:0120039 plasma membrane bounded cell projection morphogenesis 60/979 662/18670 0e+00 0.0006 60
GO:0048812 neuron projection morphogenesis 59/979 648/18670 0e+00 0.0006 59
GO:0032615 interleukin-12 production 12/979 56/18670 0e+00 0.0006 12
GO:0009306 protein secretion 55/979 591/18670 0e+00 0.0006 55
GO:0038093 Fc receptor signaling pathway 29/979 241/18670 0e+00 0.0006 29
GO:0002366 leukocyte activation involved in immune response 63/979 707/18670 0e+00 0.0006 63
GO:0003012 muscle system process 46/979 465/18670 0e+00 0.0006 46
GO:0045333 cellular respiration 25/979 193/18670 0e+00 0.0006 25
GO:0045088 regulation of innate immune response 45/979 452/18670 0e+00 0.0006 45
GO:0043068 positive regulation of programmed cell death 61/979 680/18670 0e+00 0.0006 61
GO:0048858 cell projection morphogenesis 60/979 666/18670 0e+00 0.0006 60
GO:0050684 regulation of mRNA processing 20/979 137/18670 0e+00 0.0006 20
GO:0006937 regulation of muscle contraction 23/979 171/18670 0e+00 0.0007 23
GO:0002263 cell activation involved in immune response 63/979 711/18670 0e+00 0.0007 63
GO:0030100 regulation of endocytosis 32/979 281/18670 0e+00 0.0007 32
GO:0075733 intracellular transport of virus 12/979 57/18670 0e+00 0.0007 12
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 30/979 256/18670 0e+00 0.0007 30
GO:0034284 response to monosaccharide 26/979 207/18670 0e+00 0.0007 26
GO:2000736 regulation of stem cell differentiation 18/979 116/18670 0e+00 0.0007 18
GO:0006470 protein dephosphorylation 35/979 321/18670 0e+00 0.0007 35
GO:0043401 steroid hormone mediated signaling pathway 24/979 184/18670 0e+00 0.0007 24
GO:0002757 immune response-activating signal transduction 58/979 641/18670 0e+00 0.0007 58
GO:0032990 cell part morphogenesis 61/979 685/18670 0e+00 0.0007 61
GO:0018209 peptidyl-serine modification 35/979 322/18670 0e+00 0.0007 35
GO:0030099 myeloid cell differentiation 42/979 416/18670 0e+00 0.0008 42
GO:0010942 positive regulation of cell death 64/979 730/18670 0e+00 0.0008 64
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 27/979 221/18670 0e+00 0.0008 27
GO:1901990 regulation of mitotic cell cycle phase transition 44/979 444/18670 0e+00 0.0008 44
GO:0071900 regulation of protein serine/threonine kinase activity 49/979 515/18670 0e+00 0.0008 49
GO:0015980 energy derivation by oxidation of organic compounds 32/979 285/18670 0e+00 0.0008 32
GO:1902600 proton transmembrane transport 22/979 163/18670 0e+00 0.0009 22
GO:0043900 regulation of multi-organism process 41/979 405/18670 0e+00 0.0009 41
GO:0044770 cell cycle phase transition 57/979 631/18670 0e+00 0.0009 57
GO:0015696 ammonium transport 17/979 108/18670 0e+00 0.0009 17
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 17/979 108/18670 0e+00 0.0009 17
GO:0000122 negative regulation of transcription by RNA polymerase II 71/979 839/18670 0e+00 0.0009 71
GO:0001678 cellular glucose homeostasis 21/979 152/18670 0e+00 0.0009 21
GO:2001233 regulation of apoptotic signaling pathway 41/979 406/18670 0e+00 0.0009 41
GO:0051091 positive regulation of DNA-binding transcription factor activity 30/979 261/18670 0e+00 0.0009 30
GO:0030163 protein catabolic process 77/979 931/18670 0e+00 0.0009 77
GO:0008286 insulin receptor signaling pathway 20/979 141/18670 0e+00 0.0009 20
GO:0030155 regulation of cell adhesion 61/979 691/18670 0e+00 0.0009 61
GO:0048024 regulation of mRNA splicing, via spliceosome 16/979 98/18670 0e+00 0.0009 16
GO:0071363 cellular response to growth factor stimulus 62/979 706/18670 0e+00 0.0009 62
GO:0006520 cellular amino acid metabolic process 38/979 366/18670 0e+00 0.0009 38
GO:0070372 regulation of ERK1 and ERK2 cascade 33/979 300/18670 0e+00 0.0009 33
GO:0010498 proteasomal protein catabolic process 46/979 477/18670 1e-04 0.0010 46
GO:1903047 mitotic cell cycle process 73/979 873/18670 1e-04 0.0010 73
GO:0042110 T cell activation 45/979 464/18670 1e-04 0.0010 45
GO:0090175 regulation of establishment of planar polarity 17/979 110/18670 1e-04 0.0011 17
GO:0035690 cellular response to drug 38/979 369/18670 1e-04 0.0011 38
GO:0051954 positive regulation of amine transport 9/979 35/18670 1e-04 0.0011 9
GO:0060284 regulation of cell development 78/979 953/18670 1e-04 0.0011 78
GO:0007610 behavior 54/979 594/18670 1e-04 0.0011 54
GO:0070371 ERK1 and ERK2 cascade 34/979 317/18670 1e-04 0.0011 34
GO:0043254 regulation of protein complex assembly 45/979 467/18670 1e-04 0.0011 45
GO:0045666 positive regulation of neuron differentiation 38/979 371/18670 1e-04 0.0012 38
GO:0044839 cell cycle G2/M phase transition 30/979 266/18670 1e-04 0.0012 30
GO:0045664 regulation of neuron differentiation 58/979 656/18670 1e-04 0.0012 58
GO:0002573 myeloid leukocyte differentiation 25/979 204/18670 1e-04 0.0013 25
GO:0051962 positive regulation of nervous system development 50/979 541/18670 1e-04 0.0013 50
GO:0032147 activation of protein kinase activity 35/979 333/18670 1e-04 0.0013 35
GO:0051272 positive regulation of cellular component movement 53/979 585/18670 1e-04 0.0013 53
GO:0015837 amine transport 16/979 102/18670 1e-04 0.0014 16
GO:1903039 positive regulation of leukocyte cell-cell adhesion 26/979 218/18670 1e-04 0.0014 26
GO:0001889 liver development 19/979 135/18670 1e-04 0.0014 19
GO:0043484 regulation of RNA splicing 19/979 135/18670 1e-04 0.0014 19
GO:0001736 establishment of planar polarity 18/979 124/18670 1e-04 0.0014 18
GO:0007164 establishment of tissue polarity 18/979 124/18670 1e-04 0.0014 18
GO:0051101 regulation of DNA binding 18/979 124/18670 1e-04 0.0014 18
GO:0002521 leukocyte differentiation 48/979 515/18670 1e-04 0.0014 48
GO:0019226 transmission of nerve impulse 13/979 72/18670 1e-04 0.0014 13
GO:0007584 response to nutrient 26/979 219/18670 1e-04 0.0015 26
GO:0002064 epithelial cell development 25/979 207/18670 1e-04 0.0015 25
GO:0018108 peptidyl-tyrosine phosphorylation 37/979 363/18670 1e-04 0.0015 37
GO:0032655 regulation of interleukin-12 production 11/979 54/18670 1e-04 0.0016 11
GO:0043405 regulation of MAP kinase activity 35/979 337/18670 1e-04 0.0016 35
GO:0007623 circadian rhythm 25/979 208/18670 1e-04 0.0016 25
GO:0042098 T cell proliferation 23/979 184/18670 1e-04 0.0017 23
GO:0002758 innate immune response-activating signal transduction 32/979 298/18670 1e-04 0.0017 32
GO:0046822 regulation of nucleocytoplasmic transport 16/979 104/18670 1e-04 0.0017 16
GO:0090257 regulation of muscle system process 29/979 259/18670 1e-04 0.0017 29
GO:0018212 peptidyl-tyrosine modification 37/979 366/18670 1e-04 0.0018 37
GO:1903708 positive regulation of hemopoiesis 23/979 185/18670 1e-04 0.0018 23
GO:0061008 hepaticobiliary system development 19/979 138/18670 1e-04 0.0018 19
GO:0046777 protein autophosphorylation 27/979 235/18670 1e-04 0.0018 27
GO:0002886 regulation of myeloid leukocyte mediated immunity 11/979 55/18670 1e-04 0.0018 11
GO:1901991 negative regulation of mitotic cell cycle phase transition 28/979 248/18670 1e-04 0.0019 28
GO:0045089 positive regulation of innate immune response 38/979 381/18670 1e-04 0.0019 38
GO:0007569 cell aging 17/979 116/18670 1e-04 0.0019 17
GO:0060249 anatomical structure homeostasis 42/979 437/18670 1e-04 0.0019 42
GO:0045137 development of primary sexual characteristics 26/979 223/18670 1e-04 0.0019 26
GO:0051960 regulation of nervous system development 75/979 927/18670 1e-04 0.0019 75
GO:0016572 histone phosphorylation 9/979 38/18670 1e-04 0.0019 9
GO:0051588 regulation of neurotransmitter transport 19/979 139/18670 1e-04 0.0019 19
GO:1901987 regulation of cell cycle phase transition 45/979 480/18670 1e-04 0.0019 45
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 15/979 95/18670 1e-04 0.0019 15
GO:0051651 maintenance of location in cell 15/979 95/18670 1e-04 0.0019 15
GO:0051952 regulation of amine transport 15/979 95/18670 1e-04 0.0019 15
GO:0097193 intrinsic apoptotic signaling pathway 31/979 289/18670 1e-04 0.0021 31
GO:0098586 cellular response to virus 11/979 56/18670 1e-04 0.0021 11
GO:0050851 antigen receptor-mediated signaling pathway 33/979 316/18670 1e-04 0.0021 33
GO:0090277 positive regulation of peptide hormone secretion 15/979 96/18670 1e-04 0.0022 15
GO:0051048 negative regulation of secretion 27/979 238/18670 1e-04 0.0022 27
GO:0000380 alternative mRNA splicing, via spliceosome 13/979 76/18670 1e-04 0.0023 13
GO:0048598 embryonic morphogenesis 52/979 586/18670 1e-04 0.0023 52
GO:0002888 positive regulation of myeloid leukocyte mediated immunity 8/979 31/18670 1e-04 0.0023 8
GO:0050900 leukocyte migration 46/979 499/18670 1e-04 0.0023 46
GO:0046034 ATP metabolic process 32/979 305/18670 2e-04 0.0024 32
GO:0070848 response to growth factor 62/979 736/18670 2e-04 0.0024 62
GO:0009746 response to hexose 24/979 202/18670 2e-04 0.0024 24
GO:0051052 regulation of DNA metabolic process 41/979 429/18670 2e-04 0.0024 41
GO:0002218 activation of innate immune response 33/979 319/18670 2e-04 0.0025 33
GO:0070374 positive regulation of ERK1 and ERK2 cascade 25/979 215/18670 2e-04 0.0025 25
GO:0060047 heart contraction 30/979 280/18670 2e-04 0.0026 30
GO:0033119 negative regulation of RNA splicing 7/979 24/18670 2e-04 0.0026 7
GO:0071902 positive regulation of protein serine/threonine kinase activity 34/979 334/18670 2e-04 0.0026 34
GO:0070997 neuron death 35/979 348/18670 2e-04 0.0027 35
GO:0008361 regulation of cell size 22/979 179/18670 2e-04 0.0027 22
GO:0051099 positive regulation of binding 22/979 179/18670 2e-04 0.0027 22
GO:0010976 positive regulation of neuron projection development 30/979 281/18670 2e-04 0.0027 30
GO:0022409 positive regulation of cell-cell adhesion 28/979 255/18670 2e-04 0.0027 28
GO:0045921 positive regulation of exocytosis 14/979 88/18670 2e-04 0.0028 14
GO:0008406 gonad development 25/979 217/18670 2e-04 0.0028 25
GO:0071322 cellular response to carbohydrate stimulus 19/979 144/18670 2e-04 0.0029 19
GO:0044257 cellular protein catabolic process 64/979 773/18670 2e-04 0.0030 64
GO:0042060 wound healing 50/979 564/18670 2e-04 0.0030 50
GO:0010564 regulation of cell cycle process 65/979 789/18670 2e-04 0.0030 65
GO:0007159 leukocyte cell-cell adhesion 34/979 337/18670 2e-04 0.0030 34
GO:0002768 immune response-regulating cell surface receptor signaling pathway 46/979 506/18670 2e-04 0.0030 46
GO:0045165 cell fate commitment 29/979 270/18670 2e-04 0.0030 29
GO:0006897 endocytosis 67/979 820/18670 2e-04 0.0030 67
GO:0098660 inorganic ion transmembrane transport 68/979 836/18670 2e-04 0.0031 68
GO:1903522 regulation of blood circulation 31/979 297/18670 2e-04 0.0031 31
GO:0032890 regulation of organic acid transport 11/979 59/18670 2e-04 0.0031 11
GO:0051051 negative regulation of transport 47/979 522/18670 2e-04 0.0032 47
GO:1903312 negative regulation of mRNA metabolic process 13/979 79/18670 2e-04 0.0032 13
GO:0039535 regulation of RIG-I signaling pathway 6/979 18/18670 2e-04 0.0032 6
GO:0043406 positive regulation of MAP kinase activity 28/979 258/18670 2e-04 0.0032 28
GO:0050804 modulation of chemical synaptic transmission 41/979 436/18670 2e-04 0.0032 41
GO:0050434 positive regulation of viral transcription 9/979 41/18670 2e-04 0.0032 9
GO:0046683 response to organophosphorus 18/979 134/18670 2e-04 0.0032 18
GO:0007346 regulation of mitotic cell cycle 56/979 656/18670 2e-04 0.0033 56
GO:0051384 response to glucocorticoid 19/979 146/18670 2e-04 0.0033 19
GO:0099177 regulation of trans-synaptic signaling 41/979 437/18670 2e-04 0.0033 41
GO:0048872 homeostasis of number of cells 27/979 246/18670 2e-04 0.0034 27
GO:0018279 protein N-linked glycosylation via asparagine 8/979 33/18670 2e-04 0.0034 8
GO:2000147 positive regulation of cell motility 50/979 568/18670 2e-04 0.0034 50
GO:0038061 NIK/NF-kappaB signaling 22/979 183/18670 2e-04 0.0035 22
GO:0050792 regulation of viral process 24/979 208/18670 2e-04 0.0035 24
GO:0010506 regulation of autophagy 33/979 327/18670 3e-04 0.0035 33
GO:0051236 establishment of RNA localization 23/979 196/18670 3e-04 0.0036 23
GO:0007599 hemostasis 34/979 341/18670 3e-04 0.0036 34
GO:0046717 acid secretion 17/979 124/18670 3e-04 0.0036 17
GO:0045639 positive regulation of myeloid cell differentiation 14/979 91/18670 3e-04 0.0037 14
GO:0002223 stimulatory C-type lectin receptor signaling pathway 16/979 113/18670 3e-04 0.0037 16
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 25/979 222/18670 3e-04 0.0037 25
GO:0071326 cellular response to monosaccharide stimulus 18/979 136/18670 3e-04 0.0037 18
GO:0019369 arachidonic acid metabolic process 10/979 51/18670 3e-04 0.0037 10
GO:0050817 coagulation 34/979 342/18670 3e-04 0.0037 34
GO:0060560 developmental growth involved in morphogenesis 26/979 235/18670 3e-04 0.0037 26
GO:0009749 response to glucose 23/979 197/18670 3e-04 0.0038 23
GO:0015850 organic hydroxy compound transport 28/979 262/18670 3e-04 0.0039 28
GO:0007369 gastrulation 22/979 185/18670 3e-04 0.0039 22
GO:0048645 animal organ formation 11/979 61/18670 3e-04 0.0040 11
GO:0018196 peptidyl-asparagine modification 8/979 34/18670 3e-04 0.0040 8
GO:0032892 positive regulation of organic acid transport 8/979 34/18670 3e-04 0.0040 8
GO:0035967 cellular response to topologically incorrect protein 20/979 161/18670 3e-04 0.0040 20
GO:0032091 negative regulation of protein binding 15/979 103/18670 3e-04 0.0041 15
GO:0046641 positive regulation of alpha-beta T cell proliferation 6/979 19/18670 3e-04 0.0041 6
GO:0048025 negative regulation of mRNA splicing, via spliceosome 6/979 19/18670 3e-04 0.0041 6
GO:1990182 exosomal secretion 6/979 19/18670 3e-04 0.0041 6
GO:0022900 electron transport chain 22/979 186/18670 3e-04 0.0041 22
GO:0003015 heart process 30/979 290/18670 3e-04 0.0041 30
GO:0050708 regulation of protein secretion 43/979 472/18670 3e-04 0.0041 43
GO:0032479 regulation of type I interferon production 17/979 126/18670 3e-04 0.0041 17
GO:0071214 cellular response to abiotic stimulus 33/979 331/18670 3e-04 0.0041 33
GO:0104004 cellular response to environmental stimulus 33/979 331/18670 3e-04 0.0041 33
GO:1903037 regulation of leukocyte cell-cell adhesion 31/979 304/18670 3e-04 0.0042 31
GO:0017038 protein import 23/979 199/18670 3e-04 0.0042 23
GO:0035966 response to topologically incorrect protein 23/979 199/18670 3e-04 0.0042 23
GO:0031960 response to corticosteroid 20/979 162/18670 3e-04 0.0042 20
GO:0003009 skeletal muscle contraction 9/979 43/18670 3e-04 0.0042 9
GO:0034383 low-density lipoprotein particle clearance 9/979 43/18670 3e-04 0.0042 9
GO:1904646 cellular response to amyloid-beta 9/979 43/18670 3e-04 0.0042 9
GO:0002429 immune response-activating cell surface receptor signaling pathway 43/979 473/18670 3e-04 0.0042 43
GO:0009410 response to xenobiotic stimulus 30/979 292/18670 3e-04 0.0045 30
GO:0043632 modification-dependent macromolecule catabolic process 54/979 637/18670 3e-04 0.0045 54
GO:0045785 positive regulation of cell adhesion 38/979 403/18670 4e-04 0.0045 38
GO:0031115 negative regulation of microtubule polymerization 5/979 13/18670 4e-04 0.0046 5
GO:0051656 establishment of organelle localization 45/979 504/18670 4e-04 0.0046 45
GO:0016055 Wnt signaling pathway 46/979 519/18670 4e-04 0.0046 46
GO:0002220 innate immune response activating cell surface receptor signaling pathway 16/979 116/18670 4e-04 0.0046 16
GO:1900180 regulation of protein localization to nucleus 16/979 116/18670 4e-04 0.0046 16
GO:0006970 response to osmotic stress 13/979 83/18670 4e-04 0.0046 13
GO:0006986 response to unfolded protein 21/979 176/18670 4e-04 0.0047 21
GO:0032606 type I interferon production 17/979 128/18670 4e-04 0.0048 17
GO:0034620 cellular response to unfolded protein 18/979 140/18670 4e-04 0.0049 18
GO:0072331 signal transduction by p53 class mediator 28/979 267/18670 4e-04 0.0049 28
GO:1901988 negative regulation of cell cycle phase transition 28/979 267/18670 4e-04 0.0049 28
GO:0010463 mesenchymal cell proliferation 9/979 44/18670 4e-04 0.0049 9
GO:0042987 amyloid precursor protein catabolic process 9/979 44/18670 4e-04 0.0049 9
GO:0046688 response to copper ion 9/979 44/18670 4e-04 0.0049 9
GO:0098609 cell-cell adhesion 67/979 839/18670 4e-04 0.0049 67
GO:0031349 positive regulation of defense response 46/979 521/18670 4e-04 0.0049 46
GO:0198738 cell-cell signaling by wnt 46/979 521/18670 4e-04 0.0049 46
GO:0042391 regulation of membrane potential 40/979 434/18670 4e-04 0.0049 40
GO:0022904 respiratory electron transport chain 16/979 117/18670 4e-04 0.0050 16
GO:0015931 nucleobase-containing compound transport 26/979 241/18670 4e-04 0.0050 26
GO:0016311 dephosphorylation 43/979 478/18670 4e-04 0.0050 43
GO:0007596 blood coagulation 33/979 336/18670 4e-04 0.0051 33
GO:0039529 RIG-I signaling pathway 6/979 20/18670 4e-04 0.0051 6
GO:0042053 regulation of dopamine metabolic process 6/979 20/18670 4e-04 0.0051 6
GO:0042069 regulation of catecholamine metabolic process 6/979 20/18670 4e-04 0.0051 6
GO:0097734 extracellular exosome biogenesis 6/979 20/18670 4e-04 0.0051 6
GO:0001738 morphogenesis of a polarized epithelium 18/979 141/18670 4e-04 0.0051 18
GO:1904645 response to amyloid-beta 10/979 54/18670 4e-04 0.0053 10
GO:0034762 regulation of transmembrane transport 49/979 568/18670 4e-04 0.0053 49
GO:0030104 water homeostasis 12/979 74/18670 4e-04 0.0053 12
GO:0040017 positive regulation of locomotion 51/979 598/18670 4e-04 0.0053 51
GO:1903827 regulation of cellular protein localization 46/979 524/18670 4e-04 0.0054 46
GO:0000209 protein polyubiquitination 31/979 310/18670 4e-04 0.0054 31
GO:0002244 hematopoietic progenitor cell differentiation 20/979 166/18670 4e-04 0.0054 20
GO:0046782 regulation of viral transcription 11/979 64/18670 4e-04 0.0054 11
GO:0034764 positive regulation of transmembrane transport 23/979 204/18670 5e-04 0.0055 23
GO:0017157 regulation of exocytosis 24/979 217/18670 5e-04 0.0055 24
GO:0044087 regulation of cellular component biogenesis 74/979 954/18670 5e-04 0.0055 74
GO:0006611 protein export from nucleus 21/979 179/18670 5e-04 0.0056 21
GO:0098662 inorganic cation transmembrane transport 61/979 752/18670 5e-04 0.0056 61
GO:0050686 negative regulation of mRNA processing 7/979 28/18670 5e-04 0.0057 7
GO:0051123 RNA polymerase II preinitiation complex assembly 7/979 28/18670 5e-04 0.0057 7
GO:2001236 regulation of extrinsic apoptotic signaling pathway 19/979 155/18670 5e-04 0.0058 19
GO:0006353 DNA-templated transcription, termination 12/979 75/18670 5e-04 0.0059 12
GO:0030162 regulation of proteolysis 66/979 831/18670 5e-04 0.0059 66
GO:1901796 regulation of signal transduction by p53 class mediator 21/979 180/18670 5e-04 0.0059 21
GO:0009167 purine ribonucleoside monophosphate metabolic process 33/979 340/18670 5e-04 0.0059 33
GO:0032526 response to retinoic acid 15/979 108/18670 5e-04 0.0059 15
GO:0050657 nucleic acid transport 22/979 193/18670 5e-04 0.0060 22
GO:0050658 RNA transport 22/979 193/18670 5e-04 0.0060 22
GO:0000381 regulation of alternative mRNA splicing, via spliceosome 11/979 65/18670 5e-04 0.0060 11
GO:0032760 positive regulation of tumor necrosis factor production 13/979 86/18670 5e-04 0.0060 13
GO:0042775 mitochondrial ATP synthesis coupled electron transport 14/979 97/18670 5e-04 0.0060 14
GO:0051591 response to cAMP 14/979 97/18670 5e-04 0.0060 14
GO:0031346 positive regulation of cell projection organization 36/979 383/18670 5e-04 0.0061 36
GO:0016049 cell growth 43/979 484/18670 5e-04 0.0061 43
GO:0009126 purine nucleoside monophosphate metabolic process 33/979 341/18670 5e-04 0.0061 33
GO:0042129 regulation of T cell proliferation 19/979 156/18670 5e-04 0.0062 19
GO:0042177 negative regulation of protein catabolic process 17/979 132/18670 5e-04 0.0062 17
GO:0051129 negative regulation of cellular component organization 60/979 741/18670 5e-04 0.0063 60
GO:0030335 positive regulation of cell migration 47/979 544/18670 5e-04 0.0063 47
GO:2000142 regulation of DNA-templated transcription, initiation 8/979 37/18670 6e-04 0.0063 8
GO:0051168 nuclear export 22/979 194/18670 6e-04 0.0063 22
GO:0019058 viral life cycle 32/979 328/18670 6e-04 0.0063 32
GO:0006289 nucleotide-excision repair 15/979 109/18670 6e-04 0.0063 15
GO:0002438 acute inflammatory response to antigenic stimulus 6/979 21/18670 6e-04 0.0063 6
GO:0014821 phasic smooth muscle contraction 6/979 21/18670 6e-04 0.0063 6
GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 6/979 21/18670 6e-04 0.0063 6
GO:0006511 ubiquitin-dependent protein catabolic process 52/979 620/18670 6e-04 0.0064 52
GO:0042773 ATP synthesis coupled electron transport 14/979 98/18670 6e-04 0.0065 14
GO:0050848 regulation of calcium-mediated signaling 14/979 98/18670 6e-04 0.0065 14
GO:0051480 regulation of cytosolic calcium ion concentration 34/979 357/18670 6e-04 0.0066 34
GO:0050879 multicellular organismal movement 10/979 56/18670 6e-04 0.0066 10
GO:0050881 musculoskeletal movement 10/979 56/18670 6e-04 0.0066 10
GO:0071333 cellular response to glucose stimulus 17/979 133/18670 6e-04 0.0066 17
GO:0050670 regulation of lymphocyte proliferation 23/979 208/18670 6e-04 0.0066 23
GO:0002697 regulation of immune effector process 41/979 458/18670 6e-04 0.0067 41
GO:0006939 smooth muscle contraction 15/979 110/18670 6e-04 0.0068 15
GO:0033559 unsaturated fatty acid metabolic process 15/979 110/18670 6e-04 0.0068 15
GO:0051235 maintenance of location 32/979 330/18670 6e-04 0.0068 32
GO:0050770 regulation of axonogenesis 21/979 183/18670 6e-04 0.0069 21
GO:0032481 positive regulation of type I interferon production 12/979 77/18670 6e-04 0.0069 12
GO:0048678 response to axon injury 12/979 77/18670 6e-04 0.0069 12
GO:0051851 modification by host of symbiont morphology or physiology 12/979 77/18670 6e-04 0.0069 12
GO:0070663 regulation of leukocyte proliferation 24/979 222/18670 6e-04 0.0070 24
GO:0032944 regulation of mononuclear cell proliferation 23/979 209/18670 6e-04 0.0070 23
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 13/979 88/18670 6e-04 0.0071 13
GO:0030334 regulation of cell migration 73/979 950/18670 7e-04 0.0071 73
GO:0045926 negative regulation of growth 26/979 249/18670 7e-04 0.0071 26
GO:0007411 axon guidance 28/979 276/18670 7e-04 0.0071 28
GO:0051590 positive regulation of neurotransmitter transport 8/979 38/18670 7e-04 0.0072 8
GO:0051650 establishment of vesicle localization 29/979 290/18670 7e-04 0.0072 29
GO:0055114 oxidation-reduction process 76/979 999/18670 7e-04 0.0073 76
GO:0022037 metencephalon development 15/979 111/18670 7e-04 0.0073 15
GO:0097529 myeloid leukocyte migration 23/979 210/18670 7e-04 0.0073 23
GO:0002262 myeloid cell homeostasis 18/979 147/18670 7e-04 0.0074 18
GO:0097485 neuron projection guidance 28/979 277/18670 7e-04 0.0074 28
GO:0006405 RNA export from nucleus 17/979 135/18670 7e-04 0.0075 17
GO:0071331 cellular response to hexose stimulus 17/979 135/18670 7e-04 0.0075 17
GO:0046649 lymphocyte activation 59/979 733/18670 7e-04 0.0075 59
GO:0070498 interleukin-1-mediated signaling pathway 14/979 100/18670 7e-04 0.0075 14
GO:0019941 modification-dependent protein catabolic process 52/979 626/18670 7e-04 0.0075 52
GO:0090066 regulation of anatomical structure size 44/979 506/18670 7e-04 0.0075 44
GO:1902532 negative regulation of intracellular signal transduction 48/979 566/18670 7e-04 0.0076 48
GO:0031099 regeneration 22/979 198/18670 7e-04 0.0077 22
GO:0009314 response to radiation 40/979 448/18670 7e-04 0.0078 40
GO:0140112 extracellular vesicle biogenesis 6/979 22/18670 7e-04 0.0078 6
GO:0008016 regulation of heart contraction 26/979 251/18670 7e-04 0.0078 26
GO:0006354 DNA-templated transcription, elongation 15/979 112/18670 7e-04 0.0078 15
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 5/979 15/18670 8e-04 0.0079 5
GO:0017014 protein nitrosylation 5/979 15/18670 8e-04 0.0079 5
GO:0018119 peptidyl-cysteine S-nitrosylation 5/979 15/18670 8e-04 0.0079 5
GO:0032648 regulation of interferon-beta production 9/979 48/18670 8e-04 0.0079 9
GO:0097006 regulation of plasma lipoprotein particle levels 14/979 101/18670 8e-04 0.0081 14
GO:0098930 axonal transport 10/979 58/18670 8e-04 0.0082 10
GO:0009205 purine ribonucleoside triphosphate metabolic process 32/979 335/18670 8e-04 0.0083 32
GO:0051402 neuron apoptotic process 25/979 239/18670 8e-04 0.0083 25
GO:0015844 monoamine transport 13/979 90/18670 8e-04 0.0083 13
GO:0030901 midbrain development 13/979 90/18670 8e-04 0.0083 13
GO:0008277 regulation of G protein-coupled receptor signaling pathway 18/979 149/18670 8e-04 0.0084 18
GO:0014074 response to purine-containing compound 18/979 149/18670 8e-04 0.0084 18
GO:0043200 response to amino acid 15/979 113/18670 8e-04 0.0084 15
GO:0060964 regulation of gene silencing by miRNA 15/979 113/18670 8e-04 0.0084 15
GO:0010038 response to metal ion 34/979 364/18670 8e-04 0.0084 34
GO:0006979 response to oxidative stress 40/979 451/18670 8e-04 0.0085 40
GO:0043062 extracellular structure organization 38/979 422/18670 8e-04 0.0086 38
GO:0021549 cerebellum development 14/979 102/18670 9e-04 0.0088 14
GO:0006914 autophagy 43/979 496/18670 9e-04 0.0088 43
GO:0061919 process utilizing autophagic mechanism 43/979 496/18670 9e-04 0.0088 43
GO:0008088 axo-dendritic transport 11/979 69/18670 9e-04 0.0088 11
GO:0051924 regulation of calcium ion transport 26/979 254/18670 9e-04 0.0089 26
GO:2001020 regulation of response to DNA damage stimulus 23/979 214/18670 9e-04 0.0089 23
GO:0097755 positive regulation of blood vessel diameter 10/979 59/18670 9e-04 0.0091 10
GO:0070838 divalent metal ion transport 42/979 483/18670 9e-04 0.0094 42
GO:0042176 regulation of protein catabolic process 35/979 381/18670 9e-04 0.0094 35
GO:0050870 positive regulation of T cell activation 22/979 202/18670 1e-03 0.0095 22
GO:0001709 cell fate determination 8/979 40/18670 1e-03 0.0095 8
GO:0048259 regulation of receptor-mediated endocytosis 14/979 103/18670 1e-03 0.0095 14
GO:0010499 proteasomal ubiquitin-independent protein catabolic process 6/979 23/18670 1e-03 0.0095 6
GO:0072215 regulation of metanephros development 6/979 23/18670 1e-03 0.0095 6
GO:2000637 positive regulation of gene silencing by miRNA 6/979 23/18670 1e-03 0.0095 6
GO:0010975 regulation of neuron projection development 43/979 499/18670 1e-03 0.0097 43
GO:0035270 endocrine system development 16/979 127/18670 1e-03 0.0098 16
GO:0071426 ribonucleoprotein complex export from nucleus 16/979 127/18670 1e-03 0.0098 16
GO:0048609 multicellular organismal reproductive process 65/979 838/18670 1e-03 0.0099 65
GO:0048871 multicellular organismal homeostasis 42/979 485/18670 1e-03 0.0099 42
GO:0050727 regulation of inflammatory response 42/979 485/18670 1e-03 0.0099 42
GO:0009161 ribonucleoside monophosphate metabolic process 33/979 354/18670 1e-03 0.0099 33

\(C^{(2)}_{u,3}\) (123 terms)

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0006521 regulation of cellular amino acid metabolic process 11/172 62/18670 0e+00 0.0000 11
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 13/172 108/18670 0e+00 0.0000 13
GO:0090175 regulation of establishment of planar polarity 13/172 110/18670 0e+00 0.0000 13
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 12/172 93/18670 0e+00 0.0000 12
GO:0001736 establishment of planar polarity 13/172 124/18670 0e+00 0.0000 13
GO:0007164 establishment of tissue polarity 13/172 124/18670 0e+00 0.0000 13
GO:0043620 regulation of DNA-templated transcription in response to stress 13/172 127/18670 0e+00 0.0000 13
GO:0033238 regulation of cellular amine metabolic process 11/172 81/18670 0e+00 0.0000 11
GO:1902750 negative regulation of cell cycle G2/M phase transition 12/172 105/18670 0e+00 0.0000 12
GO:0001738 morphogenesis of a polarized epithelium 13/172 141/18670 0e+00 0.0000 13
GO:1902036 regulation of hematopoietic stem cell differentiation 10/172 72/18670 0e+00 0.0000 10
GO:0016579 protein deubiquitination 17/172 283/18670 0e+00 0.0000 17
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 12/172 121/18670 0e+00 0.0000 12
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 11/172 96/18670 0e+00 0.0000 11
GO:0035567 non-canonical Wnt signaling pathway 13/172 150/18670 0e+00 0.0000 13
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 10/172 75/18670 0e+00 0.0000 10
GO:0070498 interleukin-1-mediated signaling pathway 11/172 100/18670 0e+00 0.0000 11
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 10/172 77/18670 0e+00 0.0000 10
GO:0070646 protein modification by small protein removal 17/172 299/18670 0e+00 0.0000 17
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 10/172 79/18670 0e+00 0.0000 10
GO:0031145 anaphase-promoting complex-dependent catabolic process 10/172 81/18670 0e+00 0.0000 10
GO:0060218 hematopoietic stem cell differentiation 10/172 83/18670 0e+00 0.0000 10
GO:1901532 regulation of hematopoietic progenitor cell differentiation 10/172 85/18670 0e+00 0.0000 10
GO:0071347 cellular response to interleukin-1 13/172 179/18670 0e+00 0.0000 13
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 19/172 419/18670 0e+00 0.0000 19
GO:1905330 regulation of morphogenesis of an epithelium 13/172 180/18670 0e+00 0.0000 13
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 10/172 95/18670 0e+00 0.0000 10
GO:0043632 modification-dependent macromolecule catabolic process 23/172 637/18670 0e+00 0.0000 23
GO:0000209 protein polyubiquitination 16/172 310/18670 0e+00 0.0000 16
GO:0044106 cellular amine metabolic process 11/172 129/18670 0e+00 0.0000 11
GO:0010389 regulation of G2/M transition of mitotic cell cycle 13/172 196/18670 0e+00 0.0000 13
GO:0002218 activation of innate immune response 16/172 319/18670 0e+00 0.0000 16
GO:0033209 tumor necrosis factor-mediated signaling pathway 12/172 167/18670 0e+00 0.0000 12
GO:1903311 regulation of mRNA metabolic process 16/172 324/18670 0e+00 0.0000 16
GO:0009308 amine metabolic process 11/172 138/18670 0e+00 0.0000 11
GO:0006511 ubiquitin-dependent protein catabolic process 22/172 620/18670 0e+00 0.0000 22
GO:0070555 response to interleukin-1 13/172 207/18670 0e+00 0.0000 13
GO:0019941 modification-dependent protein catabolic process 22/172 626/18670 0e+00 0.0000 22
GO:0002478 antigen processing and presentation of exogenous peptide antigen 12/172 175/18670 0e+00 0.0000 12
GO:1902749 regulation of cell cycle G2/M phase transition 13/172 213/18670 0e+00 0.0000 13
GO:0010498 proteasomal protein catabolic process 19/172 477/18670 0e+00 0.0000 19
GO:0043488 regulation of mRNA stability 12/172 177/18670 0e+00 0.0000 12
GO:0002223 stimulatory C-type lectin receptor signaling pathway 10/172 113/18670 0e+00 0.0000 10
GO:2000027 regulation of animal organ morphogenesis 14/172 253/18670 0e+00 0.0000 14
GO:0002758 innate immune response-activating signal transduction 15/172 298/18670 0e+00 0.0000 15
GO:0010565 regulation of cellular ketone metabolic process 12/172 181/18670 0e+00 0.0000 12
GO:0002220 innate immune response activating cell surface receptor signaling pathway 10/172 116/18670 0e+00 0.0000 10
GO:2000736 regulation of stem cell differentiation 10/172 116/18670 0e+00 0.0000 10
GO:0019884 antigen processing and presentation of exogenous antigen 12/172 182/18670 0e+00 0.0000 12
GO:0043487 regulation of RNA stability 12/172 183/18670 0e+00 0.0000 12
GO:0019882 antigen processing and presentation 13/172 226/18670 0e+00 0.0000 13
GO:0048002 antigen processing and presentation of peptide antigen 12/172 189/18670 0e+00 0.0000 12
GO:0071453 cellular response to oxygen levels 13/172 234/18670 0e+00 0.0000 13
GO:0061013 regulation of mRNA catabolic process 12/172 199/18670 0e+00 0.0000 12
GO:0038095 Fc-epsilon receptor signaling pathway 11/172 169/18670 0e+00 0.0000 11
GO:0045089 positive regulation of innate immune response 16/172 381/18670 0e+00 0.0000 16
GO:0000086 G2/M transition of mitotic cell cycle 13/172 247/18670 0e+00 0.0000 13
GO:0071456 cellular response to hypoxia 12/172 207/18670 0e+00 0.0000 12
GO:0042180 cellular ketone metabolic process 13/172 248/18670 0e+00 0.0000 13
GO:0044257 cellular protein catabolic process 23/172 773/18670 0e+00 0.0000 23
GO:0051603 proteolysis involved in cellular protein catabolic process 22/172 716/18670 0e+00 0.0000 22
GO:0070482 response to oxygen levels 16/172 394/18670 0e+00 0.0000 16
GO:0090090 negative regulation of canonical Wnt signaling pathway 11/172 178/18670 0e+00 0.0000 11
GO:0036294 cellular response to decreased oxygen levels 12/172 217/18670 0e+00 0.0000 12
GO:0006401 RNA catabolic process 16/172 397/18670 0e+00 0.0000 16
GO:0038061 NIK/NF-kappaB signaling 11/172 183/18670 0e+00 0.0001 11
GO:0090263 positive regulation of canonical Wnt signaling pathway 10/172 147/18670 0e+00 0.0001 10
GO:0044839 cell cycle G2/M phase transition 13/172 266/18670 0e+00 0.0001 13
GO:0001666 response to hypoxia 15/172 359/18670 0e+00 0.0001 15
GO:0031349 positive regulation of defense response 18/172 521/18670 0e+00 0.0001 18
GO:0036293 response to decreased oxygen levels 15/172 370/18670 0e+00 0.0001 15
GO:0016567 protein ubiquitination 23/172 822/18670 0e+00 0.0001 23
GO:0038093 Fc receptor signaling pathway 12/172 241/18670 0e+00 0.0001 12
GO:0050852 T cell receptor signaling pathway 11/172 202/18670 0e+00 0.0001 11
GO:0032446 protein modification by small protein conjugation 24/172 906/18670 0e+00 0.0001 24
GO:0002244 hematopoietic progenitor cell differentiation 10/172 166/18670 0e+00 0.0001 10
GO:1901991 negative regulation of mitotic cell cycle phase transition 12/172 248/18670 0e+00 0.0001 12
GO:0030178 negative regulation of Wnt signaling pathway 11/172 210/18670 0e+00 0.0002 11
GO:0045088 regulation of innate immune response 16/172 452/18670 0e+00 0.0002 16
GO:0048863 stem cell differentiation 12/172 257/18670 0e+00 0.0002 12
GO:0062012 regulation of small molecule metabolic process 16/172 459/18670 0e+00 0.0002 16
GO:0030177 positive regulation of Wnt signaling pathway 10/172 179/18670 0e+00 0.0002 10
GO:0010948 negative regulation of cell cycle process 14/172 361/18670 0e+00 0.0002 14
GO:1901988 negative regulation of cell cycle phase transition 12/172 267/18670 0e+00 0.0003 12
GO:0006520 cellular amino acid metabolic process 14/172 366/18670 0e+00 0.0003 14
GO:0002253 activation of immune response 20/172 724/18670 0e+00 0.0004 20
GO:0030163 protein catabolic process 23/172 931/18670 0e+00 0.0006 23
GO:0071356 cellular response to tumor necrosis factor 12/172 291/18670 0e+00 0.0006 12
GO:1901361 organic cyclic compound catabolic process 20/172 745/18670 0e+00 0.0006 20
GO:0016071 mRNA metabolic process 22/172 877/18670 0e+00 0.0007 22
GO:0030097 hemopoiesis 22/172 887/18670 0e+00 0.0008 22
GO:0002757 immune response-activating signal transduction 18/172 641/18670 0e+00 0.0009 18
GO:0050778 positive regulation of immune response 22/172 902/18670 0e+00 0.0010 22
GO:0034655 nucleobase-containing compound catabolic process 18/172 648/18670 0e+00 0.0010 18
GO:0019439 aromatic compound catabolic process 19/172 712/18670 0e+00 0.0011 19
GO:0034612 response to tumor necrosis factor 12/172 312/18670 0e+00 0.0011 12
GO:0006402 mRNA catabolic process 13/172 364/18670 0e+00 0.0011 13
GO:1903706 regulation of hemopoiesis 15/172 475/18670 0e+00 0.0011 15
GO:0050851 antigen receptor-mediated signaling pathway 12/172 316/18670 0e+00 0.0012 12
GO:0002009 morphogenesis of an epithelium 16/172 537/18670 0e+00 0.0012 16
GO:0048534 hematopoietic or lymphoid organ development 22/172 929/18670 0e+00 0.0014 22
GO:0002764 immune response-regulating signaling pathway 18/172 675/18670 1e-04 0.0016 18
GO:0030104 water homeostasis 6/172 74/18670 1e-04 0.0019 6
GO:0060070 canonical Wnt signaling pathway 12/172 335/18670 1e-04 0.0020 12
GO:0034976 response to endoplasmic reticulum stress 11/172 285/18670 1e-04 0.0020 11
GO:0060828 regulation of canonical Wnt signaling pathway 11/172 286/18670 1e-04 0.0021 11
GO:0045930 negative regulation of mitotic cell cycle 12/172 338/18670 1e-04 0.0021 12
GO:0046700 heterocycle catabolic process 18/172 695/18670 1e-04 0.0022 18
GO:0044270 cellular nitrogen compound catabolic process 18/172 696/18670 1e-04 0.0022 18
GO:0031347 regulation of defense response 21/172 901/18670 1e-04 0.0024 21
GO:0016055 Wnt signaling pathway 15/172 519/18670 1e-04 0.0026 15
GO:0198738 cell-cell signaling by wnt 15/172 521/18670 1e-04 0.0027 15
GO:0002520 immune system development 22/172 985/18670 1e-04 0.0029 22
GO:0002429 immune response-activating cell surface receptor signaling pathway 14/172 473/18670 1e-04 0.0034 14
GO:0043687 post-translational protein modification 12/172 361/18670 1e-04 0.0036 12
GO:0048729 tissue morphogenesis 17/172 670/18670 2e-04 0.0041 17
GO:0031329 regulation of cellular catabolic process 20/172 871/18670 2e-04 0.0041 20
GO:0000165 MAPK cascade 21/172 958/18670 2e-04 0.0052 21
GO:0023014 signal transduction by protein phosphorylation 21/172 969/18670 2e-04 0.0060 21
GO:1901990 regulation of mitotic cell cycle phase transition 13/172 444/18670 2e-04 0.0063 13
GO:0002768 immune response-regulating cell surface receptor signaling pathway 14/172 506/18670 3e-04 0.0064 14
GO:0009894 regulation of catabolic process 21/172 979/18670 3e-04 0.0067 21
GO:0050891 multicellular organismal water homeostasis 5/172 68/18670 4e-04 0.0099 5