Sim_EISI_2015

Sim_EISI_2015

Sim_EISI_2015(
  dag,
  terms,
  IC_method = "IC_annotation",
  verbose = simona_opt$verbose
)

Methods

Sim_EISI_2015

The IC method is fixed to IC_annotation.

It also selects a subset of common ancestors of terms a and b. It only selects common ancestors which can reach a or b via one of its child terms that does not belong to the common ancestors. In other words, from the common ancestor, there exist a path where the information is uniquely transmitted to a or b, not passing the other.

Then the mean IC of the subset common ancestors is calculated and normalized by the Lin_1998 method.

Paper link: doi:10.1016/j.gene.2014.12.062 .